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公开(公告)号:US20070135464A1
公开(公告)日:2007-06-14
申请号:US11650268
申请日:2007-01-05
Applicant: Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
Inventor: Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC: A61K31/519 , A61K31/4709 , C07D403/04
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
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公开(公告)号:US20050043330A1
公开(公告)日:2005-02-24
申请号:US10928784
申请日:2004-08-26
Applicant: Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
Inventor: Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC: A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , A61K31/519 , A61K31/517 , C07D487/02 , C07D43/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
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公开(公告)号:US20070155777A1
公开(公告)日:2007-07-05
申请号:US11709895
申请日:2007-02-21
Applicant: Simon Burkitt , Mario Cardozo , Timothy Cushing , Michael DeGraffeneid , Christopher Farthing , Xiaolin Hao , Juan Jaen , Xian Jiao , David Kopecky , Marc Labelle , Sarah Lively , Dustin McMinn , Sven Rasmussen , Youngsook Shin , Andrew Smith , Marie-Louise Smith
Inventor: Simon Burkitt , Mario Cardozo , Timothy Cushing , Michael DeGraffeneid , Christopher Farthing , Xiaolin Hao , Juan Jaen , Xian Jiao , David Kopecky , Marc Labelle , Sarah Lively , Dustin McMinn , Sven Rasmussen , Youngsook Shin , Andrew Smith , Marie-Louise Smith
IPC: A61K31/4743 , C07D498/02
CPC classification number: C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
Abstract translation: 本文提供了可用于治疗炎症,免疫调节,代谢,感染和细胞增殖性疾病或病症的化合物,组合物和方法。 特别地,本发明提供调节参与炎症,代谢,感染和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物含有稠合的杂双环。
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