摘要:
Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
摘要:
Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
摘要:
Herbicides containing at least one substituted pyrido[2,3-d]pyrimidine I ##STR1## or a plant-tolerated salt of those compounds I in which at least one of the substituents R.sup.1 to R.sup.5 is an acidic or a basic group,and at least one herbicidal active ingredient selected fromA) the group consisting of the cyclohexenone derivatives II, orB) the group consisting of the 2-(heteroaryloxy)- or 2-(4-aryloxy)-phenoxycarboxylic acid derivative.
摘要:
Methods and apparatus for the introduction of foreign substances, such as recombinant DNA, into living cell interiors is disclosed. The desired substance to be introduced is dissolved or suspended in water or another suitable liquid to form a solution which is then nebulized and frozen to produce ice particles. These ice particles are accelerated toward and impact upon a target tissue where some of the particles impregnate at least some cells in the target tissue without killing the cells. Following impregnation, the ice particles melt, leaving behind the desired substance in the protoplasm of the bombarded cell.
摘要:
The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula I, II, or III. ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
摘要:
Organic chemical compounds with ICE-inhibitory action which have structures such that they enter into an interaction with binding sites in a binding cavity.
摘要:
The present invention relates to compounds that are inhibitors of interleukin-1&bgr; converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1&bgr; converting enzyme.
摘要:
The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
摘要:
An optical demodulator in which a local oscillator reference signal and a frequency shift keyed modulated input signal are optically combined by means of an optical multiport junction. These signals are detected to produce phase-diverse electrical signals at beat frequency and electrically processed to provide a demodulated signal. The electrical processing circuitry is phase discriminating and thus produces a signal in which the amplitude is dependent upon the lead/lag phase relationship of the detected signals. The local oscillator is tuned to, and maintained at, a frequency that is midway between the FSK signal tones so that the lead or lag of phase is directly related to the frequency shift coding. The phase discriminant signal processing may be performed using envelope detection.