公开(公告)号：US20140178427A1

公开(公告)日：2014-06-26

申请号：US13883486

申请日：2011-06-24

申请人： Junjie Shan ,  Yuxia Wang ,  Wei Jiang ,  Junhua Wu ,  Peiyuan Jia ,  Ting Zhu ,  Xiunan Zhao ,  Yulin Diao ,  Chenyu Wang

发明人： Junjie Shan ,  Yuxia Wang ,  Wei Jiang ,  Junhua Wu ,  Peiyuan Jia ,  Ting Zhu ,  Xiunan Zhao ,  Yulin Diao ,  Chenyu Wang

IPC分类号： A61K39/39 ,  A61K47/36 ,  A61K39/145

CPC分类号： A61K47/36 ,  A61K36/31 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/55583

摘要： The present invention pertains to medicinal technical field, relates to a Radix isatidis total polysaccharide and fractions thereof and their uses as vaccine adjuvant. Specifically, it relates to a Radix isatidis total polysaccharide as well as neutral polysaccharide fraction and acidic polysaccharide fraction extracted from Chinese medicinal material Radix isatidis, and to their uses as vaccine adjuvant or uses in manufacture of vaccine composition. The present invention further relates to a vaccine adjuvant and vaccine preparation comprising the above Radix isatidis total polysaccharide or polysaccharide fraction, a method for preparing antibody, and a method for immunization or inoculation. The Radix isatidis total polysaccharide as well as neutral polysaccharide fraction and acidic polysaccharide fraction of the present invention all can be used as adjuvant for attenuated vaccines, protein vaccines, DNA vaccines or polypeptide vaccines.

摘要翻译： 本发明涉及药用技术领域，涉及枸杞全多糖及其部分及其作为疫苗佐剂的用途。 具体地说，涉及一种中药多糖以及从中药材提取的中性多糖部分和酸性多糖部分，以及其用作疫苗佐剂或用于制造疫苗组合物的用途。 本发明还涉及一种疫苗佐剂和疫苗制剂，其包含上述芥子苷总多糖或多糖部分，制备抗体的方法，以及免疫接种方法。 本发明的黄芪总多糖以及中性多糖部分和酸性多糖部分都可以用作减毒疫苗，蛋白疫苗，DNA疫苗或多肽疫苗的佐剂。