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    SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
    1.
    发明申请
    SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE 审中-公开

    公开(公告)号：US20190224197A1

    公开(公告)日：2019-07-25

    申请号：US16251114

    申请日：2019-01-18

    申请人： Ning Xi ,  Liang Wang ,  Xuejin Feng ,  Min Liao

    发明人： Ning Xi ,  Liang Wang ,  Xuejin Feng ,  Min Liao

    IPC分类号： A61K31/506 ,  C07D413/14 ,  C07D403/14

    摘要： The invention relates to the preparation and use of new aminopyrirnidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

    SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
    2.
    发明申请
    SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE 有权
    取代的氨基嘧啶化合物及其使用方法

    公开(公告)号：US20150087663A1

    公开(公告)日：2015-03-26

    申请号：US14488294

    申请日：2014-09-17

    申请人： Ning Xi ,  Liang Wang ,  Zuping Wu ,  Xuejin Feng ,  Yanjun Wu

    发明人： Ning Xi ,  Liang Wang ,  Zuping Wu ,  Xuejin Feng ,  Yanjun Wu

    IPC分类号： C07D413/14 ,  C07D403/14 ,  C07D401/14 ,  A61K31/517

    CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  Y02A50/409 ,  A61K2300/00

    摘要： The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not limited to leukemias and solid tumors, in mammals, especially humans.

    摘要翻译： 本发明涉及新的氨基嘧啶衍生物作为游离形式的候选药物或其药学上可接受的盐形式及其制剂用于调节由PI3K酶的活性介导的病症或疾病的制备和用途。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗疾病或疾病的方法，例如PI3K酶在白细胞功能中起作用的免疫和炎症紊乱，以及与PI3K活性相关的过度增生性疾病， 包括但不限于白血病和实体瘤，在哺乳动物，特别是人类中。