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公开(公告)号：US20190224197A1
公开(公告)日：2019-07-25
申请号：US16251114
申请日：2019-01-18
申请人： Ning Xi , Liang Wang , Xuejin Feng , Min Liao
发明人： Ning Xi , Liang Wang , Xuejin Feng , Min Liao
IPC分类号： A61K31/506 , C07D413/14 , C07D403/14
摘要： The invention relates to the preparation and use of new aminopyrirnidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.
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公开(公告)号：US20150050239A1
公开(公告)日：2015-02-19
申请号：US13945925
申请日：2013-07-19
申请人： Ning Xi , Yanjun Wu , Min Liao , Yanming Feng
发明人： Ning Xi , Yanjun Wu , Min Liao , Yanming Feng
IPC分类号： C07D401/12 , C07D413/14 , A61K45/06 , A61K31/444 , A61K31/5377 , C07D401/14 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , A61K2300/00
摘要： The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译： 本发明提供了用于调节蛋白酪氨酸激酶活性和调节细胞活性如增殖，分化，凋亡，迁移和侵袭的新型取代的吡唑啉酮化合物，其药学上可接受的盐和制剂。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。
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公开(公告)号：US08862975B2
公开(公告)日：2014-10-14
申请号：US13235593
申请日：2011-09-19
申请人： Min Liao , Minmin Xue , Zaiyue Xue , Xiaofeng Fan
发明人： Min Liao , Minmin Xue , Zaiyue Xue , Xiaofeng Fan
摘要： Web workflow service information may include implementations, contracts, addresses, bindings, and other information that is sprinkled throughout source files, configuration files, and other locations. A service explorer extracts service information, and visualizes service information in a form that supports navigation, thereby helping developers understand and use workflow service information. A workflow service structure underlying the visualization is constructed with the extracted service information. A hierarchical node visualization of the service structure is displayed in a service explorer GUI. A developer navigates by expanding/contracting nodes, searching nodes, selecting nodes, and running tools with node-specific information, e.g., for testing, tracing, publication, workflow design, and so on. The visualization is automatically updated after service configuration changes. Node-specific source code is displayed for contract and implementation classes, and pertinent sections of configuration files are displayed for bindings and addresses. Derivation of endpoints, bindings, and addresses are displayed for implicitly set endpoints.
摘要翻译： Web工作流服务信息可以包括在源文件，配置文件和其他位置上喷洒的实现，合同，地址，绑定和其他信息。 服务浏览器提取服务信息，并以支持导航的形式可视化服务信息，从而帮助开发人员了解和使用工作流服务信息。 使用提取的服务信息构建可视化底层的工作流服务结构。 服务结构的层次结构可视化显示在服务资源管理器GUI中。 开发人员通过扩展/收缩节点，搜索节点，选择节点以及运行具有节点特定信息的工具（例如用于测试，跟踪，发布，工作流设计等）进行导航。 服务配置更改后，可视化将自动更新。 为合同和实现类显示特定于节点的源代码，并显示配置文件的相关部分以进行绑定和地址。 端点，绑定和地址的派生将显示为隐式设置的端点。
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公开(公告)号：US08767633B2
公开(公告)日：2014-07-01
申请号：US12525852
申请日：2008-01-07
申请人： Min Liao , Anna Larmo , Peter Lundh , Szilveszter Nádas , Ina Widegren
发明人： Min Liao , Anna Larmo , Peter Lundh , Szilveszter Nádas , Ina Widegren
IPC分类号： H04W4/00
CPC分类号： H04W72/042 , H04W72/1242 , H04W72/1278 , H04W88/08 , H04W92/12
摘要： A first device (124) in a High Speed Downlink Packet Access environment (100) may generate a High Speed Downlink Shared Channel data frame (700, 730, 735, 750) that includes a group of packet data units, where a first packet data unit of the group of packet data units is of a different length than a second packet data unit of the group of packet data units. The first device (124) may further transfer the High Speed Downlink Shared Channel data frame (700, 730, 735, 750) to a second device (122).
摘要翻译： 高速下行链路分组接入环境（100）中的第一设备（124）可以生成包括一组分组数据单元的高速下行链路共享信道数据帧（700,730,735,750），其中第一分组数据 分组数据单元组的单位具有与分组数据单元组的第二分组数据单元不同的长度。 第一设备（124）还可以将高速下行链路共享信道数据帧（700,730,735,750）传送到第二设备（122）。
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公开(公告)号：US11824939B1
公开(公告)日：2023-11-21
申请号：US17955608
申请日：2022-09-29
IPC分类号： H04L67/125 , G08C17/02 , A61H19/00
CPC分类号： H04L67/125 , G08C17/02 , A61H19/50 , G08C2201/30
摘要： This invention discloses an internet-based remote interactive system for sex toys, comprising: an APP server used for storing data of different users and handling different user data requests; a sex toy that can receive signals, in which, the sex toy is configured to produce actions based on the received signals; a wireless mobile device with an APP for sending signals to the sex toy, in which, the APP can send signals to the sex toy to control the sex toy action based on the user-operated virtual control panel, and can also send signals to the sex toy to control the sex toy action based on the control commands received from the APP server.
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公开(公告)号：US20110289515A1
公开(公告)日：2011-11-24
申请号：US12783070
申请日：2010-05-19
申请人： Au Ying Hung , Min Liao , Minmin Xue
发明人： Au Ying Hung , Min Liao , Minmin Xue
CPC分类号： G06F8/34
摘要： The present invention extends to methods, systems, and computer program products for generating service-access activities for workflow applications. Embodiments of the invention automatically generate service-access activities based on (e.g., Web) service metadata. One-click generation, together with encapsulation of configuration complexity, helps developers improve productivity and reduce the likelihood of making mistakes.
摘要翻译： 本发明扩展到用于为工作流应用产生服务访问活动的方法，系统和计算机程序产品。 本发明的实施例基于（例如，Web）服务元数据自动生成服务访问活动。 一键式生成以及配置复杂性的封装，有助于开发人员提高生产力并减少错误的可能性。
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公开(公告)号：US20130073994A1
公开(公告)日：2013-03-21
申请号：US13235593
申请日：2011-09-19
申请人： Min Liao , Minmin Xue , Zaiyue Xue , Xiaofeng Fan
发明人： Min Liao , Minmin Xue , Zaiyue Xue , Xiaofeng Fan
摘要： Web workflow service information may include implementations, contracts, addresses, bindings, and other information that is sprinkled throughout source files, configuration files, and other locations. A service explorer extracts service information, and visualizes service information in a form that supports navigation, thereby helping developers understand and use workflow service information. A workflow service structure underlying the visualization is constructed with the extracted service information. A hierarchical node visualization of the service structure is displayed in a service explorer GUI. A developer navigates by expanding/contracting nodes, searching nodes, selecting nodes, and running tools with node-specific information, e.g., for testing, tracing, publication, workflow design, and so on. The visualization is automatically updated after service configuration changes. Node-specific source code is displayed for contract and implementation classes, and pertinent sections of configuration files are displayed for bindings and addresses. Derivation of endpoints, bindings, and addresses are displayed for implicitly set endpoints.
摘要翻译： Web工作流服务信息可以包括在源文件，配置文件和其他位置上喷洒的实现，合同，地址，绑定和其他信息。 服务浏览器提取服务信息，并以支持导航的形式可视化服务信息，从而帮助开发人员了解和使用工作流服务信息。 使用提取的服务信息构建可视化底层的工作流服务结构。 服务结构的层次结构可视化显示在服务资源管理器GUI中。 开发人员通过扩展/收缩节点，搜索节点，选择节点以及运行具有节点特定信息的工具（例如用于测试，跟踪，发布，工作流设计等）进行导航。 服务配置更改后，可视化将自动更新。 为合同和实现类显示特定于节点的源代码，并显示配置文件的相关部分以进行绑定和地址。 端点，绑定和地址的派生将显示为隐式设置的端点。
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公开(公告)号：US20100061324A1
公开(公告)日：2010-03-11
申请号：US12525852
申请日：2008-01-07
申请人： Min Liao , Anna Larmo , Peter Lundh , Szilveszter Nadas , Ina Widegren
发明人： Min Liao , Anna Larmo , Peter Lundh , Szilveszter Nadas , Ina Widegren
CPC分类号： H04W72/042 , H04W72/1242 , H04W72/1278 , H04W88/08 , H04W92/12
摘要： A first device (124) in a High Speed Downlink Packet Access environment (100) may generate a High Speed Down-link Shared Channel data frame (700, 730, 735, 750) that includes a group of packet data units, where a first packet data unit of the group of packet data units is of a different length than a second packet data unit of the group of packet data units. The first device (124) may further transfer the High Speed Downlink Shared Channel data frame (700, 730, 735, 750) to a second device (122).
摘要翻译： 高速下行链路分组接入环境（100）中的第一设备（124）可以生成包括一组分组数据单元的高速下行链路共享信道数据帧（700,730,735,750），其中第一 分组数据单元组的分组数据单元具有与分组数据单元组的第二分组数据单元不同的长度。 第一设备（124）还可以将高速下行链路共享信道数据帧（700,730,735,750）传送到第二设备（122）。
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