公开(公告)号：US11884683B2

公开(公告)日：2024-01-30

申请号：US17057875

申请日：2019-05-31

申请人： Merck Sharp & Dohme LLC ,  Tao Yu ,  Alan Whitehead ,  Yili Chen ,  Chunrui Sun ,  Zhiyong Hu ,  Kake Zhao ,  Ronald M. Kim ,  John A. McCauley

发明人： Tao Yu ,  Alan Whitehead ,  Yili Chen ,  Chunrui Sun ,  Zhiyong Hu ,  Kake Zhao ,  Ronald M. Kim ,  John A. McCauley

IPC分类号： C07D498/22 ,  C07D471/16 ,  C07D491/22 ,  A61P31/18 ,  A61K45/06

CPC分类号： C07D498/22 ,  A61K45/06 ,  A61P31/18 ,  C07D471/16 ,  C07D491/22

摘要： The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

公开(公告)号：US20170240511A1

公开(公告)日：2017-08-24

申请号：US15517553

申请日：2015-10-08

申请人： Fez UJJAINWALLA ,  John Qiang TAN ,  Qun DANG ,  Christopher J. SINZ ,  Ming WANG ,  Jiaqiang CAI ,  Xiaoxing DU ,  Yili CHEN ,  MERCK SHARP & DOHME CORP.

发明人： FEZ UJJAINWALLA ,  JOHN QIANG TAN ,  QUN DANG ,  CHRISTOPHER J. SINZ ,  MING WANG ,  JIAQIANG CAI ,  XIAOXING DU ,  YILI CHEN

IPC分类号： C07D213/82 ,  C07D401/04

CPC分类号： C07D213/82 ,  A61P7/08 ,  C07D401/04

摘要： The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：US07116554B2

公开(公告)日：2006-10-03

申请号：US10818989

申请日：2004-04-05

申请人： Jensen Lee ,  Yili Chen ,  Chil-Wei Tsai

发明人： Jensen Lee ,  Yili Chen ,  Chil-Wei Tsai

IPC分类号： H05K7/20

CPC分类号： G06F1/1632 ,  G06F1/20 ,  H02J7/0044

摘要： A handheld electronic device cradle (300) with heat-dissipating capability is provided. The cradle is used for charging a build-in battery in a handheld electronic device (380) and connecting the handheld electronic device to a host computer so that the handheld electronic device can exchange information with the host computer. The cradle comprises a casing (310), a fan-mounting seat (350) set up in the casing, an electrical fan (351) secured to the seat and a cable (314) for connecting the cradle with the host computer. An insertion slot (311) is provided in the casing. When the handheld electronic device is inserted into the insertion slot, the cradle charges the battery in the handheld electronic device and connects the handheld electronic device with the host computer. Furthermore, the handheld electronic device can communicate with other devices through a wireless network. Heat produced by the handheld electronic device during its insertion in the cradle can be removed by the fan, which generates an air flow blowing on a hot region of the handheld electronic device to take heat away therefrom.

摘要翻译： 提供具有散热能力的手持式电子设备支架（300）。 支架用于对手持式电子设备（380）中的内置电池进行充电，并将手持电子设备连接到主机，以便手持电子设备可以与主机交换信息。 托架包括壳体（310），安装在壳体中的风扇安装座（350），固定到座椅的电风扇（351）和用于将托架与主计算机连接的电缆（314）。 插入槽（311）设置在壳体中。 当手持式电子设备插入到插槽中时，托架对手持电子设备中的电池充电，并将手持电子设备与主计算机连接。 此外，手持电子设备可以通过无线网络与其他设备进行通信。 手持电子设备在其插入支架期间产生的热量可以被风扇除去，该风扇产生在手持式电子设备的热区域上吹送的空气流以从其中吸取热量。

公开(公告)号：US10647727B2

公开(公告)日：2020-05-12

申请号：US15579115

申请日：2016-06-20

申请人： Merck Sharp & Dohme Corp. ,  Gregori J. Morriello ,  Michael P. Dwyer ,  Lehua Chang ,  Yili Chen ,  Ming Wang ,  Ashley Forster ,  Richard Berger ,  Kausik K. Nanda ,  Jamie L. Bunda ,  William D. Shipe

发明人： Gregori J. Morriello ,  Lehua Chang ,  Ashley Forster ,  Richard Berger ,  Kausik K. Nanda ,  William D. Shipe

IPC分类号： C07D487/04 ,  C07D498/04 ,  C07D473/34 ,  A61P25/06 ,  A61P25/28 ,  A61P25/18 ,  A61P25/16

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：US09695198B2

公开(公告)日：2017-07-04

申请号：US14652150

申请日：2013-12-16

申请人： Cameron James Smith ,  Edward Sherer ,  Louis-Charles Campeau ,  James Balkovec ,  William John Greenlee ,  Derun Li ,  Liangqin Guo ,  Tin-Yau Chan ,  Yi-Heng Chen ,  Yili Chen ,  Samuel Chackalamannil ,  John Qiang Tan ,  Tomokazu Hirabayashi ,  Mika Sekioka ,  MERCK SHARP & DOHME CORP. ,  MOCHIDA PHARMACEUTICAL CO., LTD.

发明人： Cameron James Smith ,  Edward Sherer ,  Louis-Charles Campeau ,  James Balkovec ,  William John Greenlee ,  Derun Li ,  Liangqin Guo ,  Tin-Yau Chan ,  Yi-Heng Chen ,  Yili Chen ,  Samuel Chackalamannil ,  John Qiang Tan ,  Tomokazu Hirabayashi ,  Mika Sekioka

IPC分类号： C07D413/14 ,  C07D417/06 ,  C07D498/04 ,  C07D513/04 ,  C07D413/12 ,  C07D471/04 ,  C07D413/06

CPC分类号： C07D513/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

摘要： The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.

公开(公告)号：US20150368269A1

公开(公告)日：2015-12-24

申请号：US14652150

申请日：2013-12-16

申请人： Tomokazu HIRABAYASHI ,  Mika KATSUNO ,  Cameron James SMITH ,  Edward SHERER ,  Louis-Charles CAMPEAU ,  James BALKOVEC ,  William John GREENLEE ,  Derun LI ,  Liangqin GUO ,  Tin Yan CHAN ,  Yi-Heng CHEN ,  Yili CHEN ,  Samuel CHACKALAMANNIL ,  John Qiang TAN ,  MERCH SHARP & DOHME CORP. ,  MOCHIDA PHARMACEUTICAL CO., LTD.

发明人： Cameron James Smith ,  Edward Sherer ,  Louis-Charles Campeau ,  James Balkovec ,  William John Greenlee ,  Derun Li ,  Liangqin Guo ,  Tin-Yau Chan ,  Yi-Heng Chen ,  Yili Chen ,  Samuel Chackalamannil ,  John Qiang Tan ,  Tomokazu Hirabayashi ,  Mika Sekioka

IPC分类号： C07D513/04 ,  C07D417/06 ,  C07D413/06 ,  C07D498/04 ,  C07D471/04

CPC分类号： C07D513/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

摘要： The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.

摘要翻译： 本发明提供式（I）化合物，其中A为杂环环系，B为杂环环系或芳环系，以及包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防的方法 血栓形成，栓塞，高凝状态或纤维化变化。

公开(公告)号：US20180162874A1

公开(公告)日：2018-06-14

申请号：US15579115

申请日：2016-06-20

申请人： Gregori J. MORRIELLO ,  Lehua CHANG ,  Ashley FORSTER ,  Yili CHEN ,  Michael P. DWYER ,  Richard BERGER ,  Ming WANG ,  Kausik K. NADA ,  Jaime L. BUNDA ,  William D. SHIPE ,  Merck Sharp & Dohme Corp.

发明人： Gregori J. Morriello ,  Michael P. Dwyer ,  Lehua Chang ,  Yili Chen ,  Ming Wang ,  Ashley Forster ,  Richard Berger ,  Kausik k Nanda ,  Jaime L Bunda ,  William D Shipe

IPC分类号： C07D498/04 ,  C07D473/34 ,  A61P25/18 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D498/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D473/34 ,  C07D487/04

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：US20210309671A1

公开(公告)日：2021-10-07

申请号：US17057875

申请日：2019-05-31

申请人： Tao Yu ,  Alan Whitehead ,  Yili Chen ,  Chunrui Sun ,  Zhiy-ong Hu ,  Kake Zhao ,  Ronald M. Kim ,  John A. McCauley ,  MERCK SHARP & DOHME CORP.

发明人： Tao YU ,  Alan WHITEHEAD ,  Yili CHEN ,  Chunrui SUN ,  Zhiyong HU ,  Kake ZHAO ,  Ronald M. KIM ,  John A. McCAULEY

IPC分类号： C07D498/22 ,  C07D471/16 ,  C07D491/22 ,  A61K45/06 ,  A61P31/18

摘要： The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, where-in R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

公开(公告)号：US20180141952A1

公开(公告)日：2018-05-24

申请号：US15736202

申请日：2016-06-27

申请人： Shawn J. STACHEL ,  Christopher J. SINZ ,  Yili CHEN ,  Jonathan E. WILSON ,  Michael P. DWYER ,  Daniel V. PAONE ,  Shimin XU ,  Merck Sharp & Dohme Corp.

发明人： Shawn J. Stachel ,  Michael P. Dwyer ,  Christopher J. Sinz ,  Jonathan E. Wilson ,  Daniel V. Paone ,  Yili Chen ,  Shimin Xu

IPC分类号： C07D487/04 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  A61P25/06 ,  A61P25/16

CPC分类号： C07D487/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28

摘要： The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：US20180134712A1

公开(公告)日：2018-05-17

申请号：US15574411

申请日：2016-05-24

申请人： Dong-Ming SHEN ,  Michael P. DWYER ,  Christopher J. SINZ ,  Deping WANG ,  Shawn J. STACHEL ,  Daniel V. PAONE ,  Ashley FORSTER ,  Richard BERGER ,  William D. SHIPE ,  Yili CHEN ,  Yimin QIAN ,  Shimin XU ,  Chunmei HU ,  Jianmin FU ,  Zhigang GUO ,  Haitang LI ,  Yingjian BO ,  Merck Sharp & Dohme Corp. ,  MSD R & D (China) Co., LTD.

发明人： Dong-Ming Shen ,  Michael P. Dwyer ,  Christopher J. Sinz ,  Deping Wang ,  Shawn J. Stachel ,  Daniel V. Paone ,  Ashley Forster ,  Richard Berger ,  Yilli Chen ,  Yimin Qian ,  Shimin Xu ,  Chunmel Hu ,  William D. Shipe ,  Jianmin Fu ,  Zhigang Guo ,  HAITANG LI ,  Yingjian Bo

IPC分类号： C07D487/04 ,  A61P25/18 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  A61P25/16

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28

摘要： The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypo-function or basal ganglia dysfunction.