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公开(公告)号：US10351558B2
公开(公告)日：2019-07-16
申请号：US15550862
申请日：2016-02-12
申请人： Merck Sharp & Dohme Corp. , Dongfang Meng , Hong Li , Meng Yang , Manuel de Lera Ruiz , Sunita V. Dewnani , Tianying Jian , Dann L. Parker, Jr. , Ting Zhang , Louis-Charles Campeau , Harold B. Wood , Jiayi Xu , Richard Berger , Jane Yang Wu , Robert K. Orr , Shawn P. Walsh , Bart Harper
发明人： Dongfang Meng , Hong Li , Meng Yang , Manuel de Lera Ruiz , Sunita V. Dewnani , Tianying Jian , Dann L. Parker, Jr. , Ting Zhang , Louis-Charles Campeau , Harold B. Wood , Jiayi Xu , Richard Berger , Jane Yang Wu , Robert K. Orr , Shawn P. Walsh , Bart Harper
IPC分类号： C07D471/04 , C07D403/12 , C07D417/14 , A61P9/00 , C07D413/14 , C07D471/14 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US20180022747A1
公开(公告)日：2018-01-25
申请号：US15550862
申请日：2016-02-12
申请人： Dongfang MENG , Hong LI , Meng YANG , Manuel de Lera RUIZ , Sunita V. DEWNANI , Tianying JIAN , Dann L. PARKER, JR. , Ting ZHANG , Louis-Charles CAMPEAU , Bart HARPER , Harold B. WOOD , Jiayi XU , Richard BERGER , Jane Yang WU , Robert K. ORR , Shawn P. WALSH , Merck Sharp & Dohme Corp.
发明人： Dongfang Meng , Hong Li , Meng Yang , Manuel de Lera Ruiz , Sunita V. Dewnani , Tianying Jian , Dann L. Parker, Jr. , Ting Zhang , Louis-Charles Campeau , Harold B. Wood , Jiayi Xu , Richard Berger , Jane Yang Wu , Robert K. Orr , Shawn P. Walsh , Bart Harper
IPC分类号： C07D471/04 , C07D403/12 , C07D498/04 , C07D417/14 , C07D513/04 , C07D471/14 , C07D413/14
CPC分类号： C07D471/04 , A61P9/00 , C07D403/12 , C07D413/14 , C07D417/14 , C07D471/14 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US20110165632A1
公开(公告)日：2011-07-07
申请号：US12993341
申请日：2009-05-18
申请人： Louis-Charles Campeau , John Y. Chung , Danny Gauvreau , Melina Girardin-Rondeau , Gregory Hughes , Kevin M. Maloney , Christophe Mellon , Jeffrey C. Moore , Paul O'Shea , Stephane Quellet
发明人： Louis-Charles Campeau , John Y. Chung , Danny Gauvreau , Melina Girardin-Rondeau , Gregory Hughes , Kevin M. Maloney , Christophe Mellon , Jeffrey C. Moore , Paul O'Shea , Stephane Quellet
IPC分类号： C12P17/16 , C07D401/14
CPC分类号： C07D401/14 , C07D233/96 , C07D401/12
摘要： The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及制备食欲肽受体拮抗剂的吡啶基哌啶化合物的方法，其可用于治疗或预防涉及食欲肽受体的神经和精神疾病及疾病。
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公开(公告)号：US20170166586A1
公开(公告)日：2017-06-15
申请号：US15325392
申请日：2015-07-10
申请人： Hongming LI , Jingjun YIN , Kevin M. BELYK , Kevin R. CAMPOS , Qinghao CHEN , Alan M. HYDE , Tetsuji ITOH , Artis KLAPARS , Mathew Thomas TUDGE , Edward CLEATOR , Aaron M. DUMAS , Louis-Charles CAMPEAU , Yonggang CHEN , Ji QI , Wensong XIAO , MERCK SHARP & DOHME CORP. , MERCK SHARP & DOHME LIMITED , MSD R&D (CHINA) CO., LTD
发明人： Hongming Li , Jingjun Yin , Kevin M. Belyk , Kevin R. Campos , Qinghao Chen , Alan M. Hyde , Tetsuji Itoh , Artis Klapars , Matthew Thomas Tudge , Edward Cleator , Aaron M. Dumas , Louis-Charles Campeau , Yonggang Chen , Ji Qi , Wensong Xiao
IPC分类号： C07D498/04 , C07F9/6509 , C07D265/14 , C07D413/04 , C07C251/24 , C07D417/04
CPC分类号： C07D498/04 , C07C251/24 , C07D239/74 , C07D265/14 , C07D265/36 , C07D413/04 , C07D413/14 , C07D417/04 , C07F9/650994 , C07F17/02
摘要： The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2 and R3 are defined above herein. The present invention is also directed to compounds that are useful as synthetic intermediates in the process of the invention.
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公开(公告)号：US20170334926A1
公开(公告)日：2017-11-23
申请号：US15524872
申请日：2015-11-05
申请人： Daniel A. DIROCCO , Ian DAVIES , Feng PENG , Mark MCLAUGHLIN , Louis-Charles CAMPEAU , Yingju XU , Merck Sharp & Dohme Corp.
发明人： Daniel A . DiRocco , Ian Davies , Feng Peng , Mark McLaughlin , Louis-Charles Campeau , Yingju Xu
IPC分类号： C07D498/04 , B01J31/18 , B01J35/00
CPC分类号： C07D498/04 , B01J31/00 , B01J31/181 , B01J35/004 , B01J2231/766 , B01J2531/827
摘要： The present invention is directed to a process for preparing Substituted Indole Compounds of Formula (I): wherein R1, R2, R3 and R4 are as defined herein. These indole compounds are useful as synthetic intermediates for making inhibitors of HCV NS5A.
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公开(公告)号：US20110053940A1
公开(公告)日：2011-03-03
申请号：US12990927
申请日：2009-05-04
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号： A61K31/4545 , C07D401/04 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/4709 , A61K31/4725 , A61P9/12 , A61P9/00 , A61P27/02 , A61P25/00 , A61P11/00 , A61P9/10 , A61P13/12
CPC分类号： C07D401/14 , C07D401/04 , C07D417/14
摘要： The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位氧代吡啶上具有式（I）的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US09695198B2
公开(公告)日：2017-07-04
申请号：US14652150
申请日：2013-12-16
申请人： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
发明人： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC分类号： C07D413/14 , C07D417/06 , C07D498/04 , C07D513/04 , C07D413/12 , C07D471/04 , C07D413/06
CPC分类号： C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
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公开(公告)号：US20150368269A1
公开(公告)日：2015-12-24
申请号：US14652150
申请日：2013-12-16
申请人： Tomokazu HIRABAYASHI , Mika KATSUNO , Cameron James SMITH , Edward SHERER , Louis-Charles CAMPEAU , James BALKOVEC , William John GREENLEE , Derun LI , Liangqin GUO , Tin Yan CHAN , Yi-Heng CHEN , Yili CHEN , Samuel CHACKALAMANNIL , John Qiang TAN , MERCH SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
发明人： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC分类号： C07D513/04 , C07D417/06 , C07D413/06 , C07D498/04 , C07D471/04
CPC分类号： C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供式（I）化合物，其中A为杂环环系，B为杂环环系或芳环系，以及包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防的方法 血栓形成，栓塞，高凝状态或纤维化变化。
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公开(公告)号：US08889714B2
公开(公告)日：2014-11-18
申请号：US12990927
申请日：2009-05-04
申请人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人： Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号： A61K31/4545 , C07D401/14 , C07D417/14 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04 , C07D417/14
摘要： The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及在4-位氧代吡啶上具有式（I）的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物，以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US08674093B2
公开(公告)日：2014-03-18
申请号：US12993341
申请日：2009-05-18
申请人： Louis-Charles Campeau , John Y. Chung , Danny Gauvreau , Melina Girardin-Rondeau , Gregory Hughes , Kevin M. Maloney , Christophe Mellon , Jeffrey C. Moore , Paul O'Shea , Stephane Ouellet
发明人： Louis-Charles Campeau , John Y. Chung , Danny Gauvreau , Melina Girardin-Rondeau , Gregory Hughes , Kevin M. Maloney , Christophe Mellon , Jeffrey C. Moore , Paul O'Shea , Stephane Ouellet
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D239/24
CPC分类号： C07D401/14 , C07D233/96 , C07D401/12
摘要： The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及制备食欲肽受体拮抗剂的吡啶基哌啶化合物的方法，其可用于治疗或预防涉及食欲肽受体的神经和精神疾病及疾病。
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