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公开(公告)号：US20090220486A1
公开(公告)日：2009-09-03
申请号：US11971069
申请日：2008-01-08
申请人： Daniel Plaksin , Avigdor Levanon , Esther Szanton , Yocheved Hagay , Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
发明人： Daniel Plaksin , Avigdor Levanon , Esther Szanton , Yocheved Hagay , Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , C07H21/00 , C12N15/74 , C12N1/00 , C12P21/00 , C07K7/00 , C40B40/10 , C40B30/04 , A61P35/00
CPC分类号： G01N33/574 , A61K2039/505 , C07K16/005 , C07K16/30 , C07K16/4241 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732
摘要： The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.
摘要翻译： 本发明提供了结合癌细胞的抗体或其片段，并且在生理现象如细胞转移和转移中是重要的。 还提供了使用其抗体片段的治疗和诊断方法和组合物。 根据本发明的方法和组合物可用于靶向治疗剂以及用于诸如癌症（包括肿瘤生长和转移，白血病，自身免疫疾病和炎症性疾病）的疾病的诊断，预后，分期和治疗。 还提供了具有用于互补结合的不同抗原结合结构域的免疫球蛋白结合结构域的文库，其中文库仅在重链CDR3中具有多样性。
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公开(公告)号：US20050266009A1
公开(公告)日：2005-12-01
申请号：US11166740
申请日：2005-06-27
申请人： Daniel Plaksin , Avigdor Levanon , Esther Szanton , Yocheved Hagay , Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
发明人： Daniel Plaksin , Avigdor Levanon , Esther Szanton , Yocheved Hagay , Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
IPC分类号： C07K16/00 , C07K16/30 , C07K16/42 , G01N33/574 , A61K39/42
CPC分类号： C07K16/005 , A61K2039/505 , C07K16/30 , C07K16/4241 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , G01N33/574
摘要： The present invention provides antibodies or fragments thereof that bind to co-receptor CCR5 or CXCR4.
摘要翻译： 本发明提供了结合共受体CCR5或CXCR4的抗体或其片段。
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公开(公告)号：US11058750B2
公开(公告)日：2021-07-13
申请号：US15780294
申请日：2016-01-12
申请人： Dov Weinberger , Tami Livnat , Yael Nisgav
发明人： Dov Weinberger , Tami Livnat , Yael Nisgav
摘要： Use of activated protein C (APC) for treatment and prevention of ocular diseases, disorders or conditions associated with retinal leakage and CNV such as age-related macular degeneration, optionally in combined therapy with anti-angiogenesis, anti-inflammatory, immunosuppressive, and anti PDGF agent.
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公开(公告)号：US20180271958A1
公开(公告)日：2018-09-27
申请号：US15780294
申请日：2016-01-12
申请人： Dov WEINBERGER , Tami LIVNAT , Yael NISGAV
发明人： Dov WEINBERGER , Tami LIVNAT , Yael NISGAV
CPC分类号： A61K38/4866 , A61K45/06 , A61P27/02 , C12Y304/21069
摘要： Use of activated protein C (APC) for treatment and prevention of ocular diseases, disorders or conditions associated with retinal leakage and CNV such as age-related macular degeneration, optionally in combined therapy with anti-angiogenesis, anti-inflammatory, immunosuppressive, and anti PDGF agent.
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公开(公告)号：US20080274100A1
公开(公告)日：2008-11-06
申请号：US11969005
申请日：2008-01-03
申请人： Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
发明人： Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/36 , A61P31/18
CPC分类号： C07K16/005 , A61K2039/505 , C07K16/30 , C07K16/4241 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , G01N33/574
摘要： The present invention provides antibodies or fragments thereof that bind to co-receptor CCR5 or CXCR4.
摘要翻译： 本发明提供了结合共受体CCR5或CXCR4的抗体或其片段。
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公开(公告)号：US20050069955A1
公开(公告)日：2005-03-31
申请号：US10880922
申请日：2004-06-30
申请人： Daniel Plaksin , Avigdor Levanon , Esther Szanton , Yocheved Hagay , Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
发明人： Daniel Plaksin , Avigdor Levanon , Esther Szanton , Yocheved Hagay , Rachel Ben-Levy , Yael Nisgav , Yariv Kanfi
CPC分类号： G01N33/574 , A61K2039/505 , C07K16/005 , C07K16/30 , C07K16/4241 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732
摘要： The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.
摘要翻译： 本发明提供了结合癌细胞的抗体或其片段，并且在生理现象如细胞转移和转移中是重要的。 还提供了使用其抗体片段的治疗和诊断方法和组合物。 根据本发明的方法和组合物可用于靶向治疗剂以及用于诸如癌症（包括肿瘤生长和转移，白血病，自身免疫疾病和炎症性疾病）的疾病的诊断，预后，分期和治疗。 还提供了具有用于互补结合的不同抗原结合结构域的免疫球蛋白结合结构域的文库，其中文库仅在重链CDR3中具有多样性。
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