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公开(公告)号:US20120288492A1
公开(公告)日:2012-11-15
申请号:US13519535
申请日:2010-12-27
申请人: Mann-Yan Kuo , Ying-Shuan Lee , Paonien Chen , Li Jung Chen , Yann Yu Lu , Yi-Ting Huang , Hung-Yi Hsu , Ping-Kuei Tsai
发明人: Mann-Yan Kuo , Ying-Shuan Lee , Paonien Chen , Li Jung Chen , Yann Yu Lu , Yi-Ting Huang , Hung-Yi Hsu , Ping-Kuei Tsai
IPC分类号: A61K31/5377 , C07D413/14 , C07D417/14 , A61K31/541 , C07D401/04 , A61K31/506 , C07D401/14 , A61K39/395 , A61K38/43 , A61P35/00 , A61P37/00 , A61P9/00 , A61P31/12 , A61P29/00 , A61P3/00 , A61P5/00 , A61P25/00 , C07D413/04
CPC分类号: C07D401/04 , C07D239/36 , C07D239/47 , C07D239/48 , C07D239/56 , C07D239/60 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14
摘要: The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.
摘要翻译: 本发明涉及式(I)的嘧啶化合物:其可用于治疗mTOR激酶或PI3K激酶相关疾病。
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公开(公告)号:US06313293B1
公开(公告)日:2001-11-06
申请号:US09516960
申请日:2000-03-01
申请人: Wen-Chih Chou , Ming-Chen Chou , Yann-Yu Lu , Shyh-Fong Chen
发明人: Wen-Chih Chou , Ming-Chen Chou , Yann-Yu Lu , Shyh-Fong Chen
IPC分类号: C07F710
CPC分类号: C07D295/182 , C07C231/02 , C07D307/24 , C07D319/16 , C07D333/38 , C07D405/12 , C07F7/188
摘要: The present invention relates to a process for the preparation of amides, comprising reacting amines with carboxylic acids in the presence of silicon amines. The present invention further relates to a process for the preparation of quinazoline derivatives, comprising reacting amines with carboxylic acids in the presence of silicon amines to obtain amides and contacting the resultant amides with quinazoline.
摘要翻译: 本发明涉及一种制备酰胺的方法,包括在硅胺存在下使胺与羧酸反应。 本发明还涉及制备喹唑啉衍生物的方法,其包括在硅胺存在下使胺与羧酸反应以获得酰胺并使得到的酰胺与喹唑啉接触。
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公开(公告)号:US20090163494A1
公开(公告)日:2009-06-25
申请号:US11960059
申请日:2007-12-19
申请人: Pao-Chiung Hong , Li-Jung Chen , Yann-Yu Lu , Tzu-Yun Lai , Huei-Ru Yang , Yi-Feng Kao , Kuei-Tai Lai , Young-Sun Lin
发明人: Pao-Chiung Hong , Li-Jung Chen , Yann-Yu Lu , Tzu-Yun Lai , Huei-Ru Yang , Yi-Feng Kao , Kuei-Tai Lai , Young-Sun Lin
IPC分类号: A61K31/5377 , C07D413/02 , C07D403/02 , C07D209/32 , A61P35/00 , A61K31/4155 , A61K31/404
CPC分类号: C07D421/06 , C07D421/14
摘要: This invention relates to selenophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cancer.
摘要翻译: 本发明涉及以下所示的式(I)的硒吩化合物:式(I)中的每个变量在说明书中定义。 这些化合物可用于治疗癌症。
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