公开(公告)号：US07943748B2

公开(公告)日：2011-05-17

申请号：US11658765

申请日：2005-07-27

Applicant: Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Yasuhara Kato ,  Masahiro Sakaitani ,  Sang-Hak Lee

Inventor： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Yasuhara Kato ,  Masahiro Sakaitani ,  Sang-Hak Lee

IPC: C07H1/00 ,  A01N43/04 ,  A61K31/70

CPC classification number: C07D409/10

Abstract: The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

Abstract translation: 本发明提供了具有降低血糖水平并且具有药物所需的优选性能如持久药物活性的功能的葡糖醇衍生物; 以及用于预防或治疗高血糖疾病如糖尿病，糖尿病并发症和肥胖症的药物组合物。 该衍生物是由式（I）表示的化合物：其中m是选自1-3的整数; R1至R4各自独立地为任选取代的烷基等; Ar1是任选取代的萘基; 和A是任选取代的杂芳基，该化合物的前药或其药学上可接受的盐。 还提供了含有化合物的药物，药物组合物等。