公开(公告)号：US08458959B2

公开(公告)日：2013-06-11

申请号：US12593645

申请日：2008-03-28

申请人： Yasuhiro Ohtake ,  Kenji Murata ,  Shigenobu Ohsawa ,  Jiro Yoshihara

发明人： Yasuhiro Ohtake ,  Kenji Murata ,  Shigenobu Ohsawa ,  Jiro Yoshihara

IPC分类号： B60J5/04

CPC分类号： B60J5/0402 ,  B60J10/21 ,  B60J10/86 ,  B60J10/88

摘要： A vehicle door frame structure has an upper sash member located along a roof panel of a vehicle body and also has a vertical pillar sash member located along a center pillar of the vehicle body. The upper sash member has, at its linear end joined to the vertical pillar sash member side, an aesthetically designed section and an inner frame portion. The aesthetically designed section is located on the outer side of the door, and the inner frame portion is located closer to the vehicle interior than the aesthetically designed section and is shorter in length than the aesthetically designed section. The vertical pillar sash member has at its upper end a superposed contact section that is superposed, in the direction of the thickness of the door, on an end of the inner frame portion of the upper sash member, and the superposed contact section and the inner frame portion are joined together while being superposed on each other.

摘要翻译： 车门框架结构具有沿着车身的车顶板定位的上框架构件，并且还具有沿着车身的中心柱定位的立柱框架构件。 上框架构件在其直线端部处连接到垂直支撑框架构件侧，具有美观设计的部分和内框架部分。 美观设计的部分位于门的外侧，并且内框架部分位于比美观设计的部分更靠近车辆内部并且比美观设计的部分的长度更短。 立柱框架构件的上端具有重叠的接触部分，其在门的厚度方向上重叠在上框架构件的内框架部分的端部上，并且叠置的接触部分和内部 框架部分彼此叠合在一起。

公开(公告)号：US06225306B1

公开(公告)日：2001-05-01

申请号：US09409349

申请日：1999-09-30

申请人： Yasuhiro Ohtake ,  Akira Naito ,  Kenji Naito ,  Hidehiko Matsukawa ,  Yoshiaki Saito ,  Hatsunori Toyofuku

发明人： Yasuhiro Ohtake ,  Akira Naito ,  Kenji Naito ,  Hidehiko Matsukawa ,  Yoshiaki Saito ,  Hatsunori Toyofuku

IPC分类号： A61K3155

CPC分类号： C07D487/04 ,  C07D513/04

摘要： A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: [In the formula (1), A represents a single bond, —CH2—, —CO—, —CS— or —SO2—; B represents a single bond or —CH2—; R1 represents a hydrogen atom, —OH, —NR11R12 (wherein R11 and R12 each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms), —OCOCH3, or a halogen atom; R2 represents a hydrogen atom or R1 and R2 form a group ═O together; R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; provided that in the formula, the absolute configuration of the position a may be either R or S]. The compound of the present invention has considerably high safety and efficacy and is useful as, in particular, a vasopressin receptor antagonist.

摘要翻译： 由以下通式（1）表示的联苯衍生物及其药学上可接受的盐：[式（1）中，A表示单键，-CH 2 - ， - CO - ， - CS-或-SO 2 - B表示单键或-CH 2 - ; R 1表示氢原子，-OH，-NR 11 R 12（其中R 11和R 12各自独立地表示氢原子或具有1〜4个碳原子的烷基），-OCOCH 3或卤素原子; R2表示氢原子或R1和R2一起形成基团= O; R3表示氢原子或碳原子数1〜4的烷基。 条件是在公式中，位置a的绝对构型可以是R或S]。 本发明的化合物具有相当高的安全性和功效，并且特别可用作加压素受体拮抗剂。

公开(公告)号：US20080076760A1

公开(公告)日：2008-03-27

申请号：US11718982

申请日：2005-11-10

申请人： Yasuhiro OHTAKE

发明人： Yasuhiro OHTAKE

IPC分类号： A61K31/5513

CPC分类号： C07D403/10 ,  C07D243/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D491/10

摘要： The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

摘要翻译： 本发明的目的是提供一种由式（1）表示的2,3,4,5-四氢-1H-1,5-苯并二氮杂衍生物或其药学上可接受的盐，其作为治疗和预防药物是有效的 糖尿病，糖尿病肾病或肾小球硬化症。

公开(公告)号：US20110099912A1

公开(公告)日：2011-05-05

申请号：US12593645

申请日：2008-03-28

申请人： Yasuhiro Ohtake ,  Kenji Murata ,  Shigenobu Ohsawa ,  Jiro Yoshihara

发明人： Yasuhiro Ohtake ,  Kenji Murata ,  Shigenobu Ohsawa ,  Jiro Yoshihara

IPC分类号： B60J5/04

CPC分类号： B60J5/0402 ,  B60J10/21 ,  B60J10/86 ,  B60J10/88

摘要： A vehicle door frame structure has an upper sash member located along a roof panel of a vehicle body and also has a vertical pillar sash member located along a center pillar of the vehicle body. The upper sash member has, at its linear end joined to the vertical pillar sash member side, an aesthetically designed section and an inner frame portion. The aesthetically designed section is located on the outer side of the door, and the inner frame portion is located closer to the vehicle interior than the aesthetically designed section and is shorter in length than the aesthetically designed section. The vertical pillar sash member has at its upper end a superposed contact section that is superposed, in the direction of the thickness of the door, on an end of the inner frame portion of the upper sash member, and the superposed contact section and the inner frame portion are joined together while being superposed on each other.

摘要翻译： 车门框架结构具有沿着车身的车顶板定位的上框架构件，并且还具有沿着车身的中心柱定位的立柱框架构件。 上框架构件在其直线端部处连接到垂直支撑框架构件侧，具有美观设计的部分和内框架部分。 美观设计的部分位于门的外侧，并且内框架部分位于比美观设计的部分更靠近车辆内部并且比美观设计的部分的长度更短。 立柱框架构件的上端具有重叠的接触部分，其在门的厚度方向上重叠在上框架构件的内框架部分的端部上，并且叠置的接触部分和内部 框架部分彼此叠合在一起。