-
公开(公告)号：US20090275048A1
公开(公告)日：2009-11-05
申请号：US12297048
申请日：2007-04-27
CPC分类号： C07K16/44 , Y10S435/81
摘要： An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate.
摘要翻译： 本发明公开了一种抗沙眼硫酸酯抗体，产生抗体的杂交瘤，检测方法和应用该抗体的检测试剂盒。 可以通过使用通过将蛋白质化学键合到硫酸阿卡拉酸获得的物质作为抗原来免疫哺乳动物来制备抗沙卡糖硫酸盐抗体。
-
2.发明授权公开(公告)号：US06383528B1
公开(公告)日：2002-05-07
申请号：US09581789
申请日：2000-06-19
申请人： Hyung Soo Ann , Hye Sook Yun-Choi , Yeong Shik Kim , Yong Oh Lee , Kyung Hee Lee , Sung An Kang
发明人： Hyung Soo Ann , Hye Sook Yun-Choi , Yeong Shik Kim , Yong Oh Lee , Kyung Hee Lee , Sung An Kang
IPC分类号： A01N6500
CPC分类号： A61K36/16 , A61K2300/00
摘要： The invention herein relates to a pharmaceutical composition comprising ticlopidine and Ginkgo biloba extract. In detail, as an anti-thrombotic preparation, the pharmaceutical composition comprising said ticlopidine and Ginkgo biloba extract with the PAF-antagonistic and anti-oxidant actions is used in combination to naturally suppress the neutropenia and agranulocytosis caused by the toxicity resulting from the repeated use of ticlopidine alone.
摘要翻译： 本发明涉及包含噻氯匹定和银杏提取物的药物组合物。 详细地，作为抗血栓形成剂，包含所述噻氯匹定和银杏叶提取物的药物组合物与PAF拮抗作用和抗氧化作用组合使用，以自然地抑制由重复使用引起的毒性引起的中性粒细胞减少和粒细胞缺乏症 单独使用噻氯匹定
-
公开(公告)号：US07915389B2
公开(公告)日：2011-03-29
申请号：US12297048
申请日：2007-04-27
CPC分类号： C07K16/44 , Y10S435/81
摘要： An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate.
摘要翻译： 本发明公开了一种抗沙眼硫酸酯抗体，产生抗体的杂交瘤，检测方法和应用该抗体的检测试剂盒。 可以通过使用通过将蛋白质化学键合到硫酸阿卡拉酸获得的物质作为抗原来免疫哺乳动物来制备抗沙卡糖硫酸盐抗体。
-
公开(公告)号：US20090280502A1
公开(公告)日：2009-11-12
申请号：US12297047
申请日：2007-04-27
CPC分类号： C07K16/44
摘要： An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate.
摘要翻译： 公开了与2-O-脱硫酸阿卡拉酸硫酸反应的抗体，产生抗体的杂交瘤，检测方法和应用抗体的检测试剂盒。 与2-O-脱硫酸阿沙拉硫酸盐反应的抗体可以通过使用通过化学键合蛋白质获得的物质作为抗原免疫哺乳动物来制备，所述物质通过将化学键合到2-O-脱硫酸阿卡拉酸硫酸酯。
-
公开(公告)号：US08158365B2
公开(公告)日：2012-04-17
申请号：US12297047
申请日：2007-04-27
CPC分类号： C07K16/44
摘要： An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate.
摘要翻译： 公开了与2-O-脱硫酸阿卡拉酸硫酸反应的抗体，产生抗体的杂交瘤，检测方法和应用抗体的检测试剂盒。 与2-O-脱硫酸阿沙拉硫酸盐反应的抗体可以通过使用通过化学键合蛋白质获得的物质作为抗原免疫哺乳动物来制备，所述物质通过将化学键合到2-O-脱硫酸阿卡拉酸硫酸酯。
-
公开(公告)号：US6028061A
公开(公告)日：2000-02-22
申请号：US99296
申请日：1998-06-18
IPC分类号： A61K31/00 , C08B37/00 , A61K31/715 , C07H13/12
CPC分类号： A61K31/737 , A61K31/00 , C08B37/0063
摘要： The present invention is based on the unexpected discovery that a molecule having as its major repeating units N-acetylglucosamine alternating in sequence with 2-O-sulfated uronic acid, inhibits FGF mitogenicity, and thus is useful in inhibiting angiogenesis. Additionally, the molecule has low toxicity and inhibits FGF mitogenicity without affecting anticoagulant activity. One preferred molecule is a glycosaminoglycan such as archaran sulfate. The molecules are in pharmaceutical compositions that can be used in the treatment of diseases which are angiogenesis-dependent.
摘要翻译： 本发明基于意想不到的发现，即具有与2- O硫酸化糖醛酸交替的主要重复单元N-乙酰葡糖胺的分子抑制FGF有丝分裂性，因此可用于抑制血管发生。 此外，该分子具有低毒性并且抑制FGF有丝分裂原性而不影响抗凝血活性。 一种优选的分子是糖胺聚糖如硫酸仿丹糖。 分子在可用于治疗血管发生依赖性疾病的药物组合物中。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.022 秒)
