公开(公告)号：US07776555B1

公开(公告)日：2010-08-17

申请号：US11822094

申请日：2007-07-02

Applicant: Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

Inventor： Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

IPC: G01N33/53

CPC classification number: G01N33/57419

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US07611703B1

公开(公告)日：2009-11-03

申请号：US11717149

申请日：2007-03-13

Applicant: Elizabeth G. Joseloff ,  Yeoun Jin Kim ,  Tao He ,  Steve Ruben

Inventor： Elizabeth G. Joseloff ,  Yeoun Jin Kim ,  Tao He ,  Steve Ruben

IPC: A61K39/395

CPC classification number: C07K14/4748 ,  A61K2039/505 ,  C07K16/3038

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.

Abstract translation: 本发明提供了诊断和检测与肾相关的疾病的方法。 本发明提供在肾脏疾病（KCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合KCAT。 本发明提供KCAT作为调节KCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肾相关的疾病的方法。