公开(公告)号：US07776555B1

公开(公告)日：2010-08-17

申请号：US11822094

申请日：2007-07-02

申请人： Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

发明人： Bruno Domon ,  Steve Ruben ,  Charles E. Birse ,  Yeoun Jin Kim ,  Tao He ,  Ian McCaffery

IPC分类号： G01N33/53

CPC分类号： G01N33/57419

摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US20080219992A1

公开(公告)日：2008-09-11

申请号：US12070053

申请日：2008-02-13

申请人： Kim Alving ,  Steve Ruben ,  Ian McCaffery ,  Bruno Domon

发明人： Kim Alving ,  Steve Ruben ,  Ian McCaffery ,  Bruno Domon

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  A61K38/17 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/566 ,  C07K16/18 ,  C12N5/16 ,  C12N5/10

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas.

公开(公告)号：US07960100B1

公开(公告)日：2011-06-14

申请号：US12077323

申请日：2008-03-17

申请人： Bruno Domon ,  Aiqun Li ,  Tao He ,  Ian McCaffery

发明人： Bruno Domon ,  Aiqun Li ,  Tao He ,  Ian McCaffery

IPC分类号： C12Q1/00 ,  G01N33/574

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K16/18 ,  C07K16/3046 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57419

摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

摘要翻译： 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CC​​AT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。

公开(公告)号：US20110296544A1

公开(公告)日：2011-12-01

申请号：US13108674

申请日：2011-05-16

申请人： Bruno DOMON ,  Alqun Li ,  Tao He ,  Ian McCaffery

发明人： Bruno DOMON ,  Alqun Li ,  Tao He ,  Ian McCaffery

IPC分类号： A61K39/395 ,  C12N9/00 ,  A61K38/43 ,  A61K38/17 ,  C07H21/00 ,  C07H21/02 ,  C07K16/28 ,  C07K16/40 ,  C07K16/42 ,  C12N1/21 ,  C12N7/01 ,  C12N5/10 ,  C12N5/16 ,  C12N1/19 ,  A01K67/027 ,  C12N5/071 ,  C12N5/09 ,  C12Q1/68 ,  G01N33/53 ,  C40B30/04 ,  G01N33/566 ,  A61P35/00 ,  C07K14/705

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K16/18 ,  C07K16/3046 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57419

摘要： The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

摘要翻译： 本发明提供了诊断和检测与结肠相关疾病的方法。 本发明提供在结肠疾病（CC​​AT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合CCAT。 本发明提供CCAT用作调节CCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与结肠相关疾病的方法。

公开(公告)号：US20060029988A1

公开(公告)日：2006-02-09

申请号：US10912582

申请日：2004-08-06

申请人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

发明人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/73 ,  G01N2800/52

摘要： Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro.

摘要翻译： 与健康细胞相比，用于诊断，检测和治疗与E-钙粘蛋白差异表达相关的胰腺疾病的方法和组合物。 还提供了E-钙粘蛋白的拮抗剂或激动剂，以及用于在体内或体外调节E-钙粘蛋白水平或活性的筛选剂的方法。

公开(公告)号：US20080076907A1

公开(公告)日：2008-03-27

申请号：US11905393

申请日：2007-09-28

申请人： Bruno Domon ,  Ian McCaffery ,  Terence Ryan

发明人： Bruno Domon ,  Ian McCaffery ,  Terence Ryan

IPC分类号： C07K1/22 ,  C07K14/00

CPC分类号： C07K14/705 ,  C07K1/14

摘要： The present invention provides a method for enriching cell surface proteins by oxidizing glycosylated protein with periodate. The present invention further provides that the cell surface proteins are obtained from intact cells either from cell lines or from tissues. The present invention provides a method not only capable of obtaining increased quantities of the cell surface proteins, but also capable of obtaining a wide ranges of proteins that are not detectable by other means.

公开(公告)号：US20060039907A1

公开(公告)日：2006-02-23

申请号：US10912585

申请日：2004-08-06

申请人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

发明人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K39/395

CPC分类号： G01N33/57438 ,  A61K2039/505 ,  C07K16/2881 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/5023 ,  G01N33/507 ,  G01N2800/52

摘要： Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of CD71 in comparison to healthy cells. Also provided are antagonists or agonists of CD71, and methods for screening agents that modulate the CD71 level or activity in vivo or in vitro.

摘要翻译： 与健康细胞相比，用于诊断，检测和治疗与CD71的差异表达相关的胰腺疾病的方法和组合物。 还提供了CD71的拮抗剂或激动剂，以及筛选在体内或体外调节CD71水平或活性的药剂的方法。

公开(公告)号：US20060029987A1

公开(公告)日：2006-02-09

申请号：US10912580

申请日：2004-08-06

申请人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

发明人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N2333/7055 ,  G01N2333/70557 ,  G01N2333/70582

摘要： Methods and compositions for diagnosing, detecting a pancreatic disease associated with differential expression of PCATs (e.g., CD49b, CD51, CD71 and E-Cadherin) in comparison to healthy cells.

摘要翻译： 与健康细胞相比，用于诊断，检测与PCAT（例如CD49b，CD51，CD71和E-钙粘蛋白）的差异表达相关的胰腺疾病的方法和组合物。

公开(公告)号：US08865413B2

公开(公告)日：2014-10-21

申请号：US13100902

申请日：2011-05-04

申请人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

发明人： Bruno Domon ,  Ian McCaffery ,  Vaibhav Narayan ,  Scott Patterson

IPC分类号： C12Q1/00 ,  G01N1/00 ,  G01N33/00 ,  G01N33/48 ,  G01N33/53 ,  G01N33/566 ,  G01N33/567 ,  G01N33/574

CPC分类号： G01N33/57438 ,  C07K14/4705 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70596 ,  C07K14/71 ,  C07K14/745 ,  C07K14/8114 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/36 ,  C07K16/38 ,  C07K16/40 ,  C07K16/4266 ,  C07K2317/24 ,  C07K2317/622 ,  C12N9/001 ,  C12N9/1044 ,  C12N9/14 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y103/01071 ,  C12Y203/02013 ,  C12Y306/03009 ,  G01N2500/00 ,  Y10T436/25

摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) and antibodies binds to PCAT. The present invention provides that PCAT is used as targets for screening agents that modulates the PCAT activities. Further, the present invention provides methods for treating diseases associated with pancreas.

摘要翻译： 本发明提供了诊断和检测与胰腺相关疾病的方法。 本发明提供在胰腺疾病（PCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合PCAT。 本发明提供PCAT作为调节PCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与胰腺相关疾病的方法。

公开(公告)号：US07348416B2

公开(公告)日：2008-03-25

申请号：US10992235

申请日：2004-11-19

申请人： Bruno Domon ,  Ian McCaffery ,  Terence Ryan

发明人： Bruno Domon ,  Ian McCaffery ,  Terence Ryan

IPC分类号： A23J1/00

CPC分类号： C07K14/705 ,  C07K1/14

摘要： The present invention provides a method for enriching cell surface proteins by oxidizing glycosylated protein with periodate. The present invention further provides that the cell surface proteins are obtained from intact cells either from cell lines or from tissues. The present invention provides a method not only capable of obtaining increased quantities of the cell surface proteins, but also capable of obtaining a wide ranges of proteins that are not detectable by other means.

摘要翻译： 本发明提供通过用高碘酸盐氧化糖基化蛋白质来富集细胞表面蛋白质的方法。 本发明进一步提供细胞表面蛋白从细胞系或组织中的完整细胞获得。 本发明提供了不仅能够获得增加量的细胞表面蛋白质而且能够获得不能以其他方式检测的广泛范围的蛋白质的方法。