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    TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF
    1.
    发明申请
    TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 有权
    用于诊断和治疗含有特异性靶向白细胞介素-4受体的肽的含有脂蛋白的癌症靶向药物递送系统及其制造方法

    公开(公告)号：US20120294931A1

    公开(公告)日：2012-11-22

    申请号：US13519821

    申请日：2010-12-29

    申请人： In San Kim ,  Byung Heon Lee ,  Maggie JM Lu ,  Hsiang-Fa Liang ,  Yi-ju Ko ,  Ya-Chin Lo ,  Li-Wen Chang ,  Ming-Cheng Wei

    发明人： In San Kim ,  Byung Heon Lee ,  Maggie JM Lu ,  Hsiang-Fa Liang ,  Yi-ju Ko ,  Ya-Chin Lo ,  Li-Wen Chang ,  Ming-Cheng Wei

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61K31/704

    CPC分类号： A61K31/704 ,  A61K9/1271 ,  A61K38/00 ,  A61K47/6911

    摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.

    摘要翻译： 本发明涉及用于诊断和治疗特异性靶向白介素-4受体的肽标记的含有脂质体的癌症靶向药物递送系统及其制造方法。 含有根据本发明制备的用IL4RPep肽标记的抗癌药物的脂质体可将药物递送至IL-4受体被特异性结合IL-4受体的IL4Rep肽过表​​达的癌细胞，并且药物递送可以识别癌症 细胞特异性地通过标记。 因此，IL4RPep肽可以增加药物对癌症组织的影响，同时显着降低对正常组织的副作用，这使得体内（分子）成像和肿瘤早期诊断成为可能。 因此，含有本发明的IL4Pep肽标记的抗癌药物的脂质体可以作为靶向药物递送系统有效地应用于癌症的诊断和治疗。