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1.发明授权Peptide for transmigration across blood brain barrier and delivery systems comprising the same 有权用于通过血脑屏障和包含其的递送系统进行迁移的肽公开(公告)号：US08697841B2
公开(公告)日：2014-04-15
申请号：US12979804
申请日：2010-12-28
申请人： Maggie J. M. Lu , Hsiang-Fa Liang , Shing-Ming Cheng , Yi-Ju Ko , Li-Wen Chang
发明人： Maggie J. M. Lu , Hsiang-Fa Liang , Shing-Ming Cheng , Yi-Ju Ko , Li-Wen Chang
CPC分类号： A61K31/7088 , A61K9/1075 , A61K9/1271 , A61K31/7105 , A61K31/711 , A61K47/6907 , A61K47/6911 , A61K49/0032 , A61K49/0082 , A61K49/0084
摘要： An isolated peptide including an amino acid sequence of SEQ ID NO: 1 is provided. The disclosure also provides a delivery system comprising a carrier having a surface, a drug or a dye encapsulated in the carrier, and the disclosed peptide (having an amino acid sequence of SEQ ID NO: 1) grafted on the surface of the carrier.
摘要翻译： 提供了包含SEQ ID NO：1的氨基酸序列的分离的肽。 本公开还提供了一种递送系统，其包含载体，该载体具有包封在载体中的表面，药物或染料，以及接枝在载体表面上的所公开的肽（具有SEQ ID NO：1的氨基酸序列）。
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公开(公告)号：US07919293B2
公开(公告)日：2011-04-05
申请号：US12381091
申请日：2009-03-06
申请人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： C12N11/04
CPC分类号： A61K9/5146 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US07858596B2
公开(公告)日：2010-12-28
申请号：US12315611
申请日：2008-12-04
申请人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A01N43/04
CPC分类号： A61K9/5146 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种蛋白质药物或生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷并且其对细胞外蛋白质药物和生物活性剂递送的增强的渗透性。
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公开(公告)号：US07604795B1
公开(公告)日：2009-10-20
申请号：US12286504
申请日：2008-09-30
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US20090155374A1
公开(公告)日：2009-06-18
申请号：US12321113
申请日：2009-01-15
申请人： Hsing-wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-wen Sung , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K9/14 , A61K38/21 , A61K39/395 , A61K38/02 , A61K31/7105 , A61P29/00 , A61P25/08 , A61P31/18
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US07348026B2
公开(公告)日：2008-03-25
申请号：US10958864
申请日：2004-10-05
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Ting-Fan Yang , Chin-Tsung Huang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Ting-Fan Yang , Chin-Tsung Huang , Hosheng Tu
CPC分类号： A61K9/5153 , A61K31/7008 , A61K31/704 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of γ-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers.
摘要翻译： 本发明公开了由与半乳糖结合的γ-PGA-PLA嵌段共聚物作为用于治疗肝癌的潜在药物递送系统的纳米颗粒。
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公开(公告)号：US20060034885A1
公开(公告)日：2006-02-16
申请号：US10929047
申请日：2004-08-27
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Chin-Tsung Huang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Chin-Tsung Huang , Hosheng Tu
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61F2/92 , A61F2210/0004 , A61F2230/0054 , A61F2230/0091 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured and arranged, in combination, radially, circumferentially and longitudinally.
摘要翻译： 本发明涉及装载药物的可生物降解支架以及用于治疗包括多层或多个区域的患者脆弱斑块的方法，每个层或区域包含其自身特定的生物降解速率及其特定的药物负载特性。 在一个实施例中，层和区域被组合和组合地径向地，周向地和纵向地布置。
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公开(公告)号：US20050163818A1
公开(公告)日：2005-07-28
申请号：US10610391
申请日：2003-06-30
申请人： Hsing-Wen Sung , Mei-Chin Chen , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61F2/00 , A61L15/28 , A61L15/32 , A61L24/10 , A61L26/00 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L27/3839 , A61F2310/00365 , A61F2310/00383 , A61L15/28 , A61L15/32 , A61L15/325 , A61L24/10 , A61L24/102 , A61L24/104 , A61L26/0023 , A61L26/0033 , A61L26/0038 , A61L27/20 , A61L27/22 , A61L27/222 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/3808 , A61L27/507 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/64 , A61L2430/40 , C08L5/08 , C08L89/00
摘要： A method for treating a target tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a crosslinking agent, loading the solidifiable drug-containing biological material onto a medical device, solidifying the drug-containing biological material; and delivering the medical device to the target tissue for treating the tissue.
摘要翻译： 一种用于治疗患者的靶组织的方法，包括组合将药物与可固化的生物材料混合，用生物材料用交联剂化学处理药物，将可凝固的药物生物材料装载到医疗装置上， 固化含药生物材料; 以及将所述医疗装置输送到所述靶组织以处理所述组织。
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公开(公告)号：US08454966B2
公开(公告)日：2013-06-04
申请号：US12807084
申请日：2010-08-27
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K38/14 , A61K31/715 , A61K47/36
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚-γ-谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其对细胞旁药物递送的增强的渗透性。
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公开(公告)号：US20100330167A1
公开(公告)日：2010-12-30
申请号：US12807084
申请日：2010-08-27
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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