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1.发明授权Therapeutic muscular dystrophy drug having bubble liposome loaded with morpholino as active ingredient 有权具有负载吗啉代作为活性成分的气泡脂质体的治疗性肌营养不良药物公开(公告)号：US09457102B2
公开(公告)日：2016-10-04
申请号：US14116316
申请日：2012-04-25
CPC分类号： A61K47/48815 , A61K9/0019 , A61K9/1271 , A61K41/0028 , A61K47/24 , A61K47/6911 , C12N15/113 , C12N15/88 , C12N2310/11 , C12N2310/3233 , C12N2310/3515 , C12N2320/32 , C12N2320/33
摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
摘要翻译： 为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。 还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞） 通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。
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2.发明申请THERAPEUTIC MUSCULAR DYSTROPHY DRUG HAVING BUBBLE LIPOSOME LOADED WITH MORPHOLINO AS ACTIVE INGREDIENT 有权具有作为活性成分的以摩尔作为负载的泡沫脂多糖的治疗性肌肉DYSTROPHY药物公开(公告)号：US20140155813A1
公开(公告)日：2014-06-05
申请号：US14116316
申请日：2012-04-25
CPC分类号： A61K47/48815 , A61K9/0019 , A61K9/1271 , A61K41/0028 , A61K47/24 , A61K47/6911 , C12N15/113 , C12N15/88 , C12N2310/11 , C12N2310/3233 , C12N2310/3515 , C12N2320/32 , C12N2320/33
摘要： To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
摘要翻译： 为了提供引入具有显着增强的细胞渗透性的PMO的技术，导致显着提高的引入效率，从而提供显着改善DMD的医学状况的治疗药物。 还提供了杜烯肌营养不良的治疗药物，其包括作为活性成分的具有与其表面结合的特异性吗啉代低聚物（PMO）的泡沫脂质体，其中将PMO引入肌肉的肌肉纤维（肌肉细胞） 通过将治疗药物施用到肌肉组织中或进入血管，然后经皮超声照射到肌肉组织，从而高效地进行组织。
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公开(公告)号：US5974330A
公开(公告)日：1999-10-26
申请号：US760686
申请日：1996-12-04
申请人： Yoichi Negishi
发明人： Yoichi Negishi
摘要： A microcellular portable telephone displays one's location, data on the location of the base station and, a data table showing the interrelation between the base station identifier code and base station location data. Pressing a specified operating key converts the base station identifier code connected to the portable telephone into data on the location of the base station by referring to the data table. The location of the base station is shown on the display device by means of the converted data.
摘要翻译： 微蜂窝移动电话显示位置，基站位置的数据和表示基站识别码与基站位置数据之间的相互关系的数据表。 按照指定的操作键，通过参考数据表将连接到便携式电话的基站识别码转换成基站位置的数据。 基站的位置通过转换的数据显示在显示装置上。
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