公开(公告)号：US20120148693A1

公开(公告)日：2012-06-14

申请号：US13400784

申请日：2012-02-21

申请人： Chang-Kyun HAN ,  Wie-Jong KWAK ,  Ki Won JOUNG ,  Hun Seung YOO ,  Do Seung KUM ,  Yong-Baik CHO ,  Keun Ho RYU ,  Hae In RHEE ,  Taek Su KIM ,  In Ho JUNG ,  So Yoon LEE ,  Jung Bum YI ,  Joo Hyon KIM ,  Key An UM

发明人： Chang-Kyun HAN ,  Wie-Jong KWAK ,  Ki Won JOUNG ,  Hun Seung YOO ,  Do Seung KUM ,  Yong-Baik CHO ,  Keun Ho RYU ,  Hae In RHEE ,  Taek Su KIM ,  In Ho JUNG ,  So Yoon LEE ,  Jung Bum YI ,  Joo Hyon KIM ,  Key An UM

IPC分类号： A61K36/716 ,  A61P19/02 ,  A61P19/04

CPC分类号： A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

摘要翻译： 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

公开(公告)号：US08048912B2

公开(公告)日：2011-11-01

申请号：US11794564

申请日：2005-06-15

申请人： Young-Dae Gong ,  Jin-Soo Seo ,  Moon-Kook Jeon ,  Wie-Jong Kwak ,  Yong-Baik Cho ,  Nam Kyu Lee ,  Eun Ju Lee ,  Jung Bum Lee ,  Jun Won Lee ,  Sukho Lee ,  Mi-Sook Dong ,  Jeong-Ran Kim

发明人： Young-Dae Gong ,  Jin-Soo Seo ,  Moon-Kook Jeon ,  Wie-Jong Kwak ,  Yong-Baik Cho ,  Nam Kyu Lee ,  Eun Ju Lee ,  Jung Bum Lee ,  Jun Won Lee ,  Sukho Lee ,  Mi-Sook Dong ,  Jeong-Ran Kim

IPC分类号： A61K31/352 ,  C07D311/60 ,  C07D311/70

CPC分类号： C07D311/70

摘要： The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.

摘要翻译： 本发明涉及一种对TGF-βb具有优异活性的新型苯并吡喃衍生物。 受体，其可以有效地用作肝脏疾病的预防和治疗剂以及若干纤维平滑酶如肝纤维化，肝硬化，肺纤维化，皮肤硬化，肾小球纤维化等; 及其药物用途。

公开(公告)号：US07601736B2

公开(公告)日：2009-10-13

申请号：US10585029

申请日：2004-12-30

申请人： Hyung Ook Kim ,  Nam Kyu Lee ,  Joo Hyon Kim ,  Hae In Rhee ,  Yong-Baik Cho ,  Je Ho Ryu ,  Nam Ho Kim ,  Keun Ho Ryu ,  Jung Bum Yi ,  Jae Yoon Jung

发明人： Hyung Ook Kim ,  Nam Kyu Lee ,  Joo Hyon Kim ,  Hae In Rhee ,  Yong-Baik Cho ,  Je Ho Ryu ,  Nam Ho Kim ,  Keun Ho Ryu ,  Jung Bum Yi ,  Jae Yoon Jung

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02

CPC分类号： C07D471/04 ,  C07D491/052

摘要： The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

摘要翻译： 本发明涉及具有抑制细胞因子产生抑制作用的新型吡啶衍生物，其涉及炎性反应，因此表明其用作治疗与炎症，免疫，慢性炎症有关的疾病的治疗剂以及具有抗炎作用的药物， 炎症和镇痛作用。 此外，本发明涉及其制造方法和含有该组合物的药物组合物。

公开(公告)号：US20080233216A1

公开(公告)日：2008-09-25

申请号：US12064449

申请日：2006-02-24

申请人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Jae-Dong Lee ,  Yong-Baik Cho ,  Nam-Jae Kim ,  Eun-Mi Cho ,  Jeong-Eun Huh ,  Yong-Hyeon Baek ,  Seung Jae Hong

发明人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Jae-Dong Lee ,  Yong-Baik Cho ,  Nam-Jae Kim ,  Eun-Mi Cho ,  Jeong-Eun Huh ,  Yong-Hyeon Baek ,  Seung Jae Hong

IPC分类号： A61K36/00 ,  A61P19/02

CPC分类号： A61K36/28 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/324

摘要： The extract of Siegesbeckiae herba of the present invention showed potent inhibitory effect on the dissociation of proteoglycan and type II collagen in chondrocyte and cartilage tissue and protecting effect on cartilage due to the inhibition of MMP-1, MMP-3 and MMP-13 activity and the restoring effect on cartilage tissue, the anti-inflammatory and antiphlogistic effect in edema animal model, anti-inflammatory effect confirmed by the inhibition test on PGE2 activity through COX-2 inhibition and the inhibition test of the reproduction of TNF-α and NO, it can be used as the therapeutics or health food for treating and preventing arthritic disease.

摘要翻译： 本发明的Siegesbeckiae草药提取物对软骨细胞和软骨组织中蛋白多糖和II型胶原的解离具有有效的抑制作用，并且由于MMP-1，MMP-3和MMP-13活性的抑制对软骨的保护作用，以及 软骨组织的恢复作用，水肿动物模型中的抗炎和消炎作用，通过COX-2抑制对PGE 2活性的抑制试验证实的抗炎作用以及TNF-α和NO的再生抑制试验 ，可用作治疗和预防关节炎疾病的治疗或保健食品。

公开(公告)号：US08652537B2

公开(公告)日：2014-02-18

申请号：US13400784

申请日：2012-02-21

申请人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

发明人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

IPC分类号： A61K36/00

CPC分类号： A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

摘要翻译： 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

公开(公告)号：US20110003018A1

公开(公告)日：2011-01-06

申请号：US12865995

申请日：2009-02-19

申请人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

发明人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

IPC分类号： A61K36/355 ,  A61K36/896 ,  A61P19/02 ,  A61P29/00

CPC分类号： A61K36/355 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/8964 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2200/306 ,  A23V2200/316

摘要： In some embodiments, a composition for the treatment and inhibition or prevention of arthritic diseases includes an extract of mixed herbs, the mixed herbs including an active ingredient with Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE.

摘要翻译： 在一些实施方案中，用于治疗和抑制或预防关节炎疾病的组合物包括混合草药的提取物，所述混合草药包括与忍冬（Ronicera japonica）THUNB和Anemarrhena asphodeloides BUNGE的活性成分。

公开(公告)号：US09833487B2

公开(公告)日：2017-12-05

申请号：US12865995

申请日：2009-02-19

申请人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

发明人： Dong-Suk Park ,  Myung Chul Yoo ,  Do-Young Choi ,  Hyung In Yang ,  Yong-Hyeon Baek ,  Jeong-Eun Huh ,  Kyoung Soo Kim ,  Yong-Baik Cho ,  In Ho Jung ,  Jong Hyun Hur ,  Jae Dong Lee

IPC分类号： A61K36/355 ,  A61K36/8964 ,  A23L33/105

CPC分类号： A61K36/355 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/8964 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2200/306 ,  A23V2200/316

摘要： In some embodiments, a composition for the treatment and inhibition or prevention of arthritic diseases includes an extract of mixed herbs, the mixed herbs including an active ingredient with Lonicera japonica THUNB and Anemarrhena asphodeloides BUNGE.

公开(公告)号：US20140030368A1

公开(公告)日：2014-01-30

申请号：US13982002

申请日：2012-01-30

申请人： Yong Baik Cho ,  Moon Kyu Kang ,  In Ho Jung ,  Jong Hyun Hur ,  Soon Han Kim ,  Kyoung Chul Jung ,  Je Young Lee ,  Seul Ki Kim ,  Jee Young Lee ,  Byung Chul Yu ,  Min-Kyong Hyon

发明人： Yong Baik Cho ,  Moon Kyu Kang ,  In Ho Jung ,  Jong Hyun Hur ,  Soon Han Kim ,  Kyoung Chul Jung ,  Je Young Lee ,  Seul Ki Kim ,  Jee Young Lee ,  Byung Chul Yu ,  Min-Kyong Hyon

IPC分类号： A61K36/704 ,  A61K36/234

CPC分类号： A61K36/704 ,  A61K36/234 ,  A61K2300/00

摘要： The present invention relates to a composition for preventing or treating a respiratory disease containing an active ingredient in the form of a mixed herbal extract of Cnidii Rhizoma and Polygoni cuspidati Radix, and relates to a production method therefor. The mixed herbal extract of Cnidii Rhizoma and Polygoni cuspidati Radix has an outstanding 5-lipoxygenase suppressing activity, airway constriction suppressing activity, airway inflammation suppressing action, ear-swelling anti-inflammatory effect and antitussive and phlegm-loosening action, and has been confirmed to be useful in preventing or treating respiratory diseases including asthma, chronic obstructive pulmonary disease, acute and chronic bronchitis, allergic rhinitis, cough, expectoration, acute lower respiratory infections (bronchitis and bronchiolitis), and acute upper respiratory infections such an pharyngitis, tonsillitis and laryngitis.

摘要翻译： 本发明涉及用于预防或治疗含有Cnidii Rhizoma和Polygoni cuspidati Radix的混合草药提取物形式的活性成分的呼吸系统疾病的组合物，涉及其生产方法。 Cnidii Rhizoma和Polygoni cuspidati Radix的混合草药提取物具有突出的5-脂氧合酶抑制活性，气道收缩抑制活性，气道炎症抑制作用，耳肿胀抗炎作用和镇咳和痰松动作用，并已被证实为 可用于预防或治疗呼吸系统疾病，包括哮喘，慢性阻塞性肺病，急性和慢性支气管炎，过敏性鼻炎，咳嗽，咳痰，急性下呼吸道感染（支气管炎和细支气管炎）以及急性上呼吸道感染如咽炎，扁桃体炎和喉炎 。

公开(公告)号：US20100310687A1

公开(公告)日：2010-12-09

申请号：US12857035

申请日：2010-08-16

申请人： Bong Cheol KIM ,  Joo Hyon Kim ,  Se Jun Yun ,  Eun Jung Noh ,  Gi Uk Jang ,  Chang-Kyun Han ,  Yong-Baik Cho ,  Wie-Jong Kwak

发明人： Bong Cheol KIM ,  Joo Hyon Kim ,  Se Jun Yun ,  Eun Jung Noh ,  Gi Uk Jang ,  Chang-Kyun Han ,  Yong-Baik Cho ,  Wie-Jong Kwak

IPC分类号： A61K36/42 ,  A61K31/704 ,  A61P1/04

CPC分类号： A61K31/70

摘要： The present invention relates to a Momordicae semen extract effective in the prevention and treatment of gastritis or gastric ulcer and momordica saponin I isolated therefrom. The Momordicae semen extract and the momordica saponin I isolated therefrom is effective in the prevention and treatment of gastritis or gastric ulcer since they prevent the damage of the gastric mucosa caused by alcohols and inhibit the secretion of gastric acid.

摘要翻译： 本发明涉及一种有效预防和治疗从其分离的胃炎或胃溃疡和苦瓜皂苷Ⅰ的苦瓜精液提取物。 从其中分离出的苦瓜精液提取物和苦瓜皂苷Ⅰ可有效预防和治疗胃炎或胃溃疡，因为它们可防止由酒精引起的胃粘膜损伤，并抑制胃酸分泌。

公开(公告)号：US07314644B2

公开(公告)日：2008-01-01

申请号：US10527139

申请日：2003-09-08

申请人： Wie-Jong Kwak ,  Yong-Baik Cho ,  Chang-Kyun Han ,  Hee Jae Shin ,  Keun Ho Ryu ,  Hunseung Yoo ,  Hae In Rhee

发明人： Wie-Jong Kwak ,  Yong-Baik Cho ,  Chang-Kyun Han ,  Hee Jae Shin ,  Keun Ho Ryu ,  Hunseung Yoo ,  Hae In Rhee

IPC分类号： A01K65/00

CPC分类号： A61K36/355

摘要： Disclosed is a method for extracting and purifying active constituents from honeysuckle (Lonicera japonica Thunb.) and its use. More particularly, this invention relates to an extraction and purification method of active constituents including sweroside from for honeysuckle stem (stem of honeysuckle where leaves are removed) by removing tannins, hardly soluble flavonoids, saponins, and the like. Thus obtained active constituents have better anti-inflammatory and analgesic effect, are safer and more stable than the conventional active constituents obtained from honeysuckle flower or honeysuckle leaves, and include sweroside which is an effective active ingredient of anti-inflammatory and analgesic drug.

摘要翻译： 公开了一种从金银花（金银花）提取和提纯活性成分的方法及其用途。 更具体地说，本发明涉及通过除去单宁，几乎不溶于黄酮，皂苷等的金银花茎（金银花茎除去叶子）的活性成分的提取和提纯方法。 由此得到的活性成分具有更好的抗炎和止痛作用，比从金银花或金银花叶中获得的常规活性成分更安全，更稳定，并且包括作为抗炎和止痛药有效活性成分的替罗非苷。