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    Ampoule for storing implant capable of maintaining humidity
    1.
    发明授权
    Ampoule for storing implant capable of maintaining humidity 有权
    用于储存能够保持湿度的植入物的安瓿瓶

    公开(公告)号：US09517115B2

    公开(公告)日：2016-12-13

    申请号：US14236652

    申请日：2012-02-10

    申请人： Yong Il Chung ,  Ju Dong Song ,  Eun Jung Kang ,  Da Mi Choi ,  Tae Gwan Eom ,  Kyoo Ok Choi ,  Su Kyoung Kim

    发明人： Yong Il Chung ,  Ju Dong Song ,  Eun Jung Kang ,  Da Mi Choi ,  Tae Gwan Eom ,  Kyoo Ok Choi ,  Su Kyoung Kim

    IPC分类号： A61B19/02 ,  A61C8/00

    CPC分类号： A61C8/0087 ,  A61C8/0013

    摘要： An ampoule for storing an implant capable of maintaining humidity includes: a container capable of airtight sealing at least momentarily or temporarily; a partition member which divides an accommodation space inside the container into two spaces, first and second spaces, and allows vaporized water molecules to be transported between the divided spaces; and a water molecule supply source which is accommodated in the first space of the two spaces divided by the partition member and supplies the vaporized water molecules. Therefore, the invention enables the construction of an environment which allows the hydrophilicity of the implant to be maintained for a long time, wherein the hydrophilicity is imparted to and protected from the surface of the implant or a coating layer formed on the surface of the implant.

    摘要翻译： 用于储存能够保持湿度的植入物的安瓿包括：能够至少暂时或暂时气密密封的容器; 分隔构件，其将容器内的容纳空间分成两个空间，第一和第二空间，并允许蒸发的水分子在分隔空间之间运输; 以及水分子供给源，其容纳在由分隔构件分隔的两个空间的第一空间中，并供给蒸发的水分子。 因此，本发明能够构建允许植入物的亲水性长时间保持的环境，其中亲水性赋予植入物表面或保护植入物的表面或形成在植入物表面上的涂层 。

    AMPOULE FOR STORING IMPLANT CAPABLE OF MAINTAINING HUMIDITY
    2.
    发明申请
    AMPOULE FOR STORING IMPLANT CAPABLE OF MAINTAINING HUMIDITY 有权
    用于存储可维护湿度的植入物

    公开(公告)号：US20140166509A1

    公开(公告)日：2014-06-19

    申请号：US14236652

    申请日：2012-02-10

    申请人： Yong Il Chung ,  Ju Dong Song ,  Eun Jung Kang ,  Da Mi Choi ,  Tae Gwan Eom ,  Kyoo Ok Choi

    发明人： Yong Il Chung ,  Ju Dong Song ,  Eun Jung Kang ,  Da Mi Choi ,  Tae Gwan Eom ,  Kyoo Ok Choi

    IPC分类号： A61C8/00

    CPC分类号： A61C8/0087 ,  A61C8/0013

    摘要： An ampoule for storing an implant capable of maintaining humidity includes: a container capable of airtight sealing at least momentarily or temporarily; a partition member which divides an accommodation space inside the container into two spaces, first and second spaces, and allows vaporized water molecules to be transported between the divided spaces; and a water molecule supply source which is accommodated in the first space of the two spaces divided by the partition member and supplies the vaporized water molecules. Therefore, the invention enables the construction of an environment which allows the hydrophilicity of the implant to be maintained for a long time, wherein the hydrophilicity is imparted to and protected from the surface of the implant or a coating layer formed on the surface of the implant.

    摘要翻译： 用于储存能够保持湿度的植入物的安瓿包括：能够至少暂时或暂时气密密封的容器; 分隔构件，其将容器内的容纳空间分成两个空间，第一和第二空间，并允许蒸发的水分子在分隔空间之间运输; 以及水分子供给源，其容纳在由分隔构件分隔的两个空间的第一空间中，并供给蒸发的水分子。 因此，本发明能够构建允许植入物的亲水性长时间保持的环境，其中亲水性赋予植入物表面或保护植入物的表面或形成在植入物表面上的涂层 。

    Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof
    3.
    发明申请
    Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof 审中-公开
    包含多糖功能化纳米颗粒和水凝胶基质的复合物，用于持续释放的药物递送系统和骨缺损替代基质及其制备方法

    公开(公告)号：US20070248675A1

    公开(公告)日：2007-10-25

    申请号：US11783339

    申请日：2007-04-09

    申请人： Gi Tae ,  Yong-Il Chung ,  Jong-Ho Lee ,  Yong Park

    发明人： Gi Tae ,  Yong-Il Chung ,  Jong-Ho Lee ,  Yong Park

    IPC分类号： A61K9/00 ,  A61K38/16

    CPC分类号： A61K9/5153 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/5192 ,  A61K38/1875

    摘要： The present invention relates to a nanoparticle-protein-hydrogel composite comprising (1) a polysaccharide-functionalized nanoparticle comprising a core composed of a biodegradable polymer, a hydrogel surface layer composed of a biocompatible polymer emulsifier, and a polysaccharide physically bound to the core and/or the hydrogel layer; (2) a protein forming a specific binding with the polysaccharide; and (3) a hydrogel matrix composed of a biocompatible polymer as a matrix for the nanoparticle. The present also relates to a drug delivery system and a bone defect replacement matrix comprising the composite for sustained release, and the preparation method thereof. Further, the present invention also provides a method for controlling the release rate of a protein drug by changing the content of the polysaccharide in a unit mass of the nanoparticle and/or by changing the content of the nanoparticle in a unit mass of the composite.

    摘要翻译： 本发明涉及一种纳米粒子 - 蛋白质 - 水凝胶复合体，其包含（1）包含由可生物降解的聚合物构成的核心的多糖官能化纳米粒子，由生物相容性聚合物乳化剂构成的水凝胶表面层和物理结合到核心上的多糖，以及 /或水凝胶层; （2）与多糖形成特异性结合的蛋白质; 和（3）由作为纳米粒子的基质的生物相容性聚合物构成的水凝胶基质。 本发明还涉及包含用于缓释的复合物的药物递送系统和骨缺损替换基质及其制备方法。 此外，本发明还提供了通过改变纳米颗粒的单位质量中的多糖的含量和/或通过改变复合材料的单位质量中的纳米颗粒的含量来控制蛋白质药物的释放速率的方法。