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    NOVEL ADENINE COMPOUND AND USE THEREOF
    2.
    发明申请
    NOVEL ADENINE COMPOUND AND USE THEREOF 审中-公开
    新颖的化合物及其用途

    公开(公告)号：US20120178743A1

    公开(公告)日：2012-07-12

    申请号：US13402850

    申请日：2012-02-22

    Applicant: Yoshiaki ISOBE ,  Haruo Takaku ,  Haruhisa Ogita ,  Masanori Tobe ,  Ayumu Kurimoto ,  Tetsuhiro Ogino ,  Hitoshi Fujita

    Inventor： Yoshiaki ISOBE ,  Haruo Takaku ,  Haruhisa Ogita ,  Masanori Tobe ,  Ayumu Kurimoto ,  Tetsuhiro Ogino ,  Hitoshi Fujita

    IPC: A61K31/52 ,  A61K31/5377 ,  A61P37/08 ,  A61P37/00 ,  A61P31/12 ,  A61P17/00 ,  C07D473/18 ,  A61K31/55

    CPC classification number: A61K31/5377 ,  A61K31/522 ,  A61K31/55

    Abstract: An antiallergic agent for topical administration containing an adenine compound of general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents —COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

    Abstract translation: 一种用于局部给药的抗过敏剂，其含有通式（1）的腺嘌呤化合物：[其中环A表示6至10元，单或双环，芳烃或5至10元单或双环芳族杂环， 选自0至2个氮原子，0或1个氧原子和0或1个硫原子的3个杂原子; n为0〜2的整数， m为0〜2的整数; R代表卤代，（取代）烷基等; X1代表氧，硫，NR1（R1代表氢或烷基）或单键; Y1表示单键，亚烷基等; Y2表示单键，亚烷基等; Z表示亚烷基; 并且Q1和Q2中的至少一个表示-COOR 10（其中R 10表示（un）取代的烷基等）等）或该化合物的药学上可接受的盐。

    NOVEL ADENINE COMPOUND
    3.
    发明申请
    NOVEL ADENINE COMPOUND 失效
    新颖的化合物

    公开(公告)号：US20100099870A1

    公开(公告)日：2010-04-22

    申请号：US12531867

    申请日：2008-03-19

    Applicant: Yoshiaki Isobe ,  Tomoaki Nakamura

    Inventor： Yoshiaki Isobe ,  Tomoaki Nakamura

    IPC: C07D473/18

    CPC classification number: C07D473/18 ,  C07D473/00

    Abstract: A novel adenine compound represented by the formula (1): [wherein R1 is substituted or unsubstituted alkyl, etc., X is oxygen, etc., A1 is 4- to 8-membered substituted or unsubstituted saturated nitrogen-containing heterocycle containing 1 to 2 hetero atom(s) selected from 1 to 2 nitrogen(s), 0 to 1 oxygen and 0 to 1 sulfur, etc., A2 is substituted or unsubstituted 6- to 10-membered aryl, etc., L1 and L2 are independently a straight chain or branched chain alkylene, etc.], or a pharmaceutically acceptable salt thereof, which is useful as a medicament.

    Abstract translation: 由式（1）表示的新型腺嘌呤化合物：其中，R 1为取代或未取代的烷基等，X为氧等，A 1为4〜8元的取代或未取代的饱和含氮杂环， 2个选自1至2个氮，0至1个氧和0至1个硫等的杂原子，A2为取代或未取代的6-至10-元芳基等，L1和L2独立地为 直链或支链亚烷基等]或其药学上可接受的盐，其可用作药物。

    User identification system and a method thereof
    4.
    发明申请
    User identification system and a method thereof 有权
    用户识别系统及其方法

    公开(公告)号：US20100011423A1

    公开(公告)日：2010-01-14

    申请号：US12379639

    申请日：2009-02-26

    Applicant: Yoshiaki Isobe ,  Takao Murakami ,  Kenta Takahashi

    Inventor： Yoshiaki Isobe ,  Takao Murakami ,  Kenta Takahashi

    IPC: H04L9/32 ,  G06F21/00

    CPC classification number: G06F21/32 ,  G06F21/31 ,  G07C9/00158

    Abstract: A service providing system using the biometrics identification without inputting the user ID poses the problem that the consideration of a service is erroneously claimed to the registered user not using the service due to the erroneous identification. According to this invention, the threshold of the value of the degree of similarity for user identification is set strictly for each registered biometrics information of the user in accordance with the declaration of the loss caused by the erroneous identification.

    Abstract translation: 在不输入用户ID的情况下使用生物特征识别的服务提供系统造成了由于错误识别而使服务错误地要求给注册用户不使用服务的问题。 根据本发明，根据由错误识别引起的损失的声明，对用户的每个登记生物特征信息严格地设定用户识别度的相似度值的阈值。

    Biometric Authenticaton System and Method with Vulnerability Verification
    5.
    发明申请
    Biometric Authenticaton System and Method with Vulnerability Verification 失效
    生物特征识别系统和脆弱性验证方法

    公开(公告)号：US20090307764A1

    公开(公告)日：2009-12-10

    申请号：US12293470

    申请日：2007-03-23

    Applicant: Yoshiaki Isobe ,  Masahiro Mimura

    Inventor： Yoshiaki Isobe ,  Masahiro Mimura

    IPC: H04L9/32 ,  G06F21/20

    CPC classification number: G06F21/32 ,  G06F21/51 ,  G06F21/577 ,  G06F2221/2101 ,  H04L9/3231

    Abstract: A biometric authentication device has a threat of an attack of pretending to be someone else by such as forgery. The present invention supports a service provider to appropriately decide the level of such threat.A vulnerability verification server 150 is provided in the system, and the vulnerability of each biometric product is centrally managed. A service provider 130 sends the information that specifies the device in which a client terminal 110 executes the biometric authentication to the vulnerability verification server 150, and receives the vulnerability information. The service provider 130 decides whether the service can be provided or not to the client terminal 110 using the vulnerability information that was received.

    Abstract translation: 生物识别认证设备有伪装的假冒伪装的威胁。 本发明支持服务提供商适当地确定这种威胁的程度。 系统中提供了一个漏洞验证服务器150，并且集中管理每个生物特征产品的漏洞。 服务提供者130将指定客户终端110的设备的信息发送到漏洞验证服务器150，并接收该漏洞信息。 服务提供者130使用接收到的漏洞信息来判定是否可以向客户终端110提供服务。

    Adenine derivatives
    7.
    发明授权
    Adenine derivatives 失效
    腺嘌呤衍生物

    公开(公告)号：US07157465B2

    公开(公告)日：2007-01-02

    申请号：US10474199

    申请日：2002-04-15

    Applicant: Yoshiaki Isobe ,  Haruhisa Ogita ,  Masanori Tobe ,  Haruo Takaku ,  Tetsuhiro Ogino ,  Ayumu Kurimoto ,  Hajime Kawakami

    Inventor： Yoshiaki Isobe ,  Haruhisa Ogita ,  Masanori Tobe ,  Haruo Takaku ,  Tetsuhiro Ogino ,  Ayumu Kurimoto ,  Hajime Kawakami

    IPC: C07D473/16 ,  C07D473/18 ,  C07D473/24 ,  A61K31/52 ,  A61K31/522

    CPC classification number: C07D473/00 ,  C07D473/16 ,  C07D473/18 ,  C07D473/24 ,  C07D473/34

    Abstract: This invention relates to an adenine derivative, a tautomer thereof, or a pharmaceutically acceptable salt thereof represented by general formula (I): wherein X represents NR3 (wherein R3 represents a hydrogen atom or C1-3 alkyl) or the like; R1 represents substituted or unsubstituted alkyl or the like; R2 represents hydroxyl or the like; and Y represents a substituted or unsubstituted aromatic hetero ring or the like. Also, the present invention relates to pharmaceuticals such as an interferon inducer, antiviral agent, anticancer agent, type 2 helper T cell selective immune response inhibitor, antiallergic agent, and immune response modulator comprising the above derivative as an active ingredient.

    Abstract translation: 本发明涉及由通式（I）表示的腺嘌呤衍生物，其互变异构体或其药学上可接受的盐：其中X表示NR 3（其中R 3表示 氢原子或C 1-3烷基）等; R 1表示取代或未取代的烷基等; R 2表示羟基等; Y表示取代或未取代的芳族杂环等。 此外，本发明涉及包含上述衍生物作为活性成分的药物，例如干扰素诱导剂，抗病毒剂，抗癌剂，2型辅助T细胞选择性免疫应答抑制剂，抗过敏剂和免疫应答调节剂。

    9-substituted 8-oxoadenine compound
    9.
    发明授权
    9-substituted 8-oxoadenine compound 有权
    9-取代的8-氧代腺嘌呤化合物

    公开(公告)号：US08012964B2

    公开(公告)日：2011-09-06

    申请号：US10593691

    申请日：2005-03-24

    Applicant: Ayumu Kurimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Hiroki Wada ,  Roger Bonnert ,  Thomas McInally

    Inventor： Ayumu Kurimoto ,  Yoshiaki Isobe ,  Stephen Brough ,  Hiroki Wada ,  Roger Bonnert ,  Thomas McInally

    IPC: C07D473/18 ,  A61K31/522 ,  A61P37/06 ,  A61P37/08 ,  A61P11/06

    CPC classification number: C07D473/18 ,  A61K31/522 ,  A61K31/5377

    Abstract: The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.

    Abstract translation: 本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元 芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基 基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其​​药学上可接受的盐。

    BIOMETRIC AUTHENTICATION METHOD AND SYSTEM
    10.
    发明申请
    BIOMETRIC AUTHENTICATION METHOD AND SYSTEM 有权
    生物识别方法与系统

    公开(公告)号：US20110185176A1

    公开(公告)日：2011-07-28

    申请号：US13057468

    申请日：2009-08-21

    Applicant: Kenta Takahashi ,  Shinji Hirata ,  Yoshiaki Isobe

    Inventor： Kenta Takahashi ,  Shinji Hirata ,  Yoshiaki Isobe

    IPC: H04L9/32

    CPC classification number: H04L63/0861 ,  G06F21/32 ,  G06F21/83 ,  G06F2221/2153 ,  G06K2009/00953 ,  G07C9/00158 ,  G07C9/00166 ,  G07C2209/12 ,  H04L9/3231 ,  H04L2209/043

    Abstract: At a registration time, a feature data array for registration is generated from biometric information acquired by a client, and a position correction template and a comparison template obtained by converting the feature data array for registration are registered in a server.At an authentication time, a feature data array for authentication is generated from biometric information acquired by the client, and converted feature data for position correction obtained by converting the feature data array for authentication is transmitted to the server. The server detects a position correction amount of the feature data array for authentication relative to the feature data array for registration using the position correction template and the converted feature data for position correction, and transmits the position correction amount to the client. The client corrects the feature data array for authentication using the position correction amount and transmits the converted feature data array for comparison to the server. The server calculates a distance between the comparison template and the converted feature data array for comparison and determines success or failure of the authentication on the basis of the distance.

    Abstract translation: 在注册时，由客户机获取的生物特征信息生成用于注册的特征数据阵列，并且通过转换用于注册的特征数据阵列获得的位置校正模板和比较模板被登记在服务器中。 在认证时刻，由客户端获取的生物特征信息生成用于认证的特征数据阵列，并且将用于认证的特征数据阵列转换获得的用于位置校正的转换特征数据发送到服务器。 服务器使用位置校正模板和转换后的位置校正特征数据检测相对于用于登记的特征数据阵列进行认证的特征数据阵列的位置校正量，并将位置校正量发送给客户端。 客户端使用位置校正量来校正特征数据阵列进行认证，并将转换的特征数据数组发送到服务器进行比较。 服务器计算比较模板和转换的特征数据阵列之间的距离进行比较，并根据距离确定认证的成功或失败。

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