公开(公告)号：US20110184031A1

公开(公告)日：2011-07-28

申请号：US12597281

申请日：2008-04-25

Applicant: Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Yoshie Hata

Inventor： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Yoshie Hata

IPC: A61K31/44 ,  C07D211/72 ,  C07D277/82 ,  C07C63/33 ,  A61K31/428 ,  A61K31/195 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  A61P1/00 ,  A61P11/00 ,  A61P25/18

CPC classification number: C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

Abstract: Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

Abstract translation: 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

公开(公告)号：US06413607B1

公开(公告)日：2002-07-02

申请号：US09701869

申请日：2000-12-05

Applicant: Chiaki Kasada ,  Yoshie Hata ,  Toshio Kawata ,  Shigeo Yasui

Inventor： Chiaki Kasada ,  Yoshie Hata ,  Toshio Kawata ,  Shigeo Yasui

IPC: B32B302

CPC classification number: C09B23/06 ,  G11B7/246 ,  G11B7/2463 ,  G11B7/2467 ,  G11B7/2472 ,  G11B7/2475 ,  G11B7/2478 ,  G11B7/248 ,  G11B7/2495 ,  G11B7/2534 ,  G11B7/2595 ,  G11B2007/24612 ,  Y10T428/21

Abstract: The present invention provides organic dye compounds which exert excellent recording characteristics in high-density optical recording media, and uses thereof. The present invention solves the objects of the present invention by providing non-symmetric trimethine cyanine dyes having a specific structure and properties, light absorbents and optical recording media comprising the cyanine dyes, and a process for preparing the cyanine dye comprising a step of reacting either 3,3-dimethyl-5-nitroindolium compounds or 3,3-dimethyl-5-sulfonamideindolium compounds, which have a reactive methyl group or an appropriate leaving group, with 3,3-dimethylbezoindolium compounds, which have a reactive methyl group or an appropriate leaving group.

Abstract translation: 本发明提供了在高密度光学记录介质中发挥优异记录特性的有机染料化合物及其应用。 本发明通过提供具有特定结构和性质的非对称三甲基花青染料，光吸收剂和包含花青染料的光学记录介质来解决本发明的目的，以及制备花青染料的方法，包括使 具有反应性甲基或合适离去基团的3,3-二甲基-5-硝基吲哚鎓化合物或3,3-二甲基-5-磺酰胺吲哚鎓化合物与3,3-二甲基联苯并噻唑鎓化合物反应，其具有反应性甲基或 适当的离开组。