公开(公告)号：US20110184031A1

公开(公告)日：2011-07-28

申请号：US12597281

申请日：2008-04-25

申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Yoshie Hata

发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Yoshie Hata

IPC分类号： A61K31/44 ,  C07D211/72 ,  C07D277/82 ,  C07C63/33 ,  A61K31/428 ,  A61K31/195 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  A61P1/00 ,  A61P11/00 ,  A61P25/18

CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

公开(公告)号：US08318781B2

公开(公告)日：2012-11-27

申请号：US12597281

申请日：2008-04-25

申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N37/12 ,  A01N37/44 ,  A01N43/00 ,  A61K31/445 ,  A61K31/425 ,  A61K31/33 ,  C07D213/72 ,  C07D213/78 ,  C07D277/82 ,  C07C63/00 ,  C07C65/00

CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

公开(公告)号：US20100274022A1

公开(公告)日：2010-10-28

申请号：US12597570

申请日：2008-04-24

申请人： Gozo Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara

发明人： Gozo Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara

IPC分类号： C07D213/55

CPC分类号： C07D213/74 ,  C07D263/58

摘要： Disclosed are a substance and a pharmaceutical product inhibiting activation of a G protein-coupled receptor. Specifically disclosed is a G protein-coupled receptor inhibitor containing a specific compound represented by the following formula (1):

摘要翻译： 公开了抑制G蛋白偶联受体活化的物质和药物。 具体公开了含有下式（1）表示的特定化合物的G蛋白偶联受体抑制剂：

公开(公告)号：US20130203738A1

公开(公告)日：2013-08-08

申请号：US13578230

申请日：2011-02-09

申请人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

发明人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

IPC分类号： C07D211/16 ,  C07D211/10 ,  C07D265/30 ,  C07D207/06 ,  C07D223/04 ,  C07D225/02 ,  C07D211/14 ,  C07C233/65

CPC分类号： C07D211/16 ,  A61K31/445 ,  C07C233/65 ,  C07C233/66 ,  C07C2601/14 ,  C07D207/06 ,  C07D211/10 ,  C07D211/14 ,  C07D211/96 ,  C07D223/04 ,  C07D225/02 ,  C07D265/30 ,  C07D295/192

摘要： The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain.The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (I), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.

摘要翻译： 本发明鉴定了与特异性结合神经限制性沉默因子NRSF的mSin3B的PAH1结构域结合的化合物，并且将该化合物用作与神经限制性消音因子NRSF / REST的异常表达相关的疾病的预防和/或治疗 或NRSF / REST靶向的基因异常表达，如亨廷顿氏病，成神经管细胞瘤和神经性疼痛。 本发明提供一种药物组合物，其包含能够结合mSin3B的PAH1结构域的物质，例如下式（I）表示的化合物，其药理学上可接受的盐或其药理学上可接受的酯：其中n表示0 或1; R1，R2，R3，R4和R5各自独立地表示氢原子，烃基或官能团; Y表示单键，羰基，-CONH-，-NHCO-或磺酰基; Z表示可以具有取代基的含氮杂环基，可以具有烃基或芳香族烃基的氨基或可以具有取代基的含氮和含氧杂环基。

公开(公告)号：US09206125B2

公开(公告)日：2015-12-08

申请号：US13578230

申请日：2011-02-09

申请人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

发明人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

IPC分类号： C07D211/16 ,  C07D211/14 ,  C07D211/10 ,  C07C233/65 ,  A61K31/445 ,  C07D211/96 ,  C07D295/192 ,  C07C233/66 ,  C07D207/06 ,  C07D223/04 ,  C07D225/02 ,  C07D265/30

CPC分类号： C07D211/16 ,  A61K31/445 ,  C07C233/65 ,  C07C233/66 ,  C07C2601/14 ,  C07D207/06 ,  C07D211/10 ,  C07D211/14 ,  C07D211/96 ,  C07D223/04 ,  C07D225/02 ,  C07D265/30 ,  C07D295/192

摘要： The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain.The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (1), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.

摘要翻译： 本发明鉴定了与特异性结合神经限制性沉默因子NRSF的mSin3B的PAH1结构域结合的化合物，并且将该化合物用作与神经限制性消音因子NRSF / REST的异常表达相关的疾病的预防和/或治疗 或NRSF / REST靶向的基因异常表达，如亨廷顿氏病，成神经管细胞瘤和神经性疼痛。 本发明提供了包含能够结合mSin3B的PAH1结构域的物质的药物组合物，例如下式（1）所示的化合物，其药理学上可接受的盐或其药理学上可接受的酯：其中n表示0 或1; R1，R2，R3，R4和R5各自独立地表示氢原子，烃基或官能团; Y表示单键，羰基，-CONH-，-NHCO-或磺酰基; Z表示可以具有取代基的含氮杂环基，可以具有烃基或芳香族烃基的氨基或可以具有取代基的含氮和含氧杂环基。

公开(公告)号：US08743395B2

公开(公告)日：2014-06-03

申请号：US12795153

申请日：2010-06-07

申请人： Hideharu Iwashita ,  Takeshi Yokoe ,  Tsuyoshi Tooda ,  Takayoshi Suzuki ,  Atsushi Mori ,  Katsue Komaki

发明人： Hideharu Iwashita ,  Takeshi Yokoe ,  Tsuyoshi Tooda ,  Takayoshi Suzuki ,  Atsushi Mori ,  Katsue Komaki

IPC分类号： G06F3/12 ,  G06K15/00

CPC分类号： H04N1/00209 ,  H04N1/00413 ,  H04N1/00437 ,  H04N1/0048 ,  H04N1/00488 ,  H04N1/0049 ,  H04N1/00928 ,  H04N2201/0093 ,  H04N2201/0094

摘要： An image forming apparatus includes a communication unit, a prohibition unit, an execution unit, and a control unit. The communication unit communicates with an external apparatus. The prohibition unit prohibits the communication unit from communicating with the external apparatus when a command for executing initialization with respect to the image forming apparatus is specified. The execution unit executes a process for accepting set information of the initialization when the prohibition unit prohibits the communication unit from communication with the external apparatus. The control unit executes a process for informing that the initialization should be executed when an elapsed time of a waiting state where input of the set information is not executed exceeds a given period.

摘要翻译： 图像形成装置包括通信单元，禁止单元，执行单元和控制单元。 通信单元与外部设备通信。 当指定用于执行关于图像形成装置的初始化的命令时，禁止单元禁止通信单元与外部设备通信。 当禁止单元禁止通信单元与外部设备通信时，执行单元执行用于接受初始化的设置信息的处理。 控制单元执行用于通知当不执行设置信息的输入的等待状态的经过时间超过给定周期时应当执行初始化的处理。

公开(公告)号：US08066539B2

公开(公告)日：2011-11-29

申请号：US12372794

申请日：2009-02-18

申请人： Takayoshi Suzuki ,  Daisuke Nakamura

发明人： Takayoshi Suzuki ,  Daisuke Nakamura

IPC分类号： B60W10/04 ,  B63H21/21

CPC分类号： B63H21/213

摘要： A marine propulsion system includes a transmission mechanism arranged to transmit a driving force generated by an engine to propellers with a speed thereof changed to a low speed reduction ratio and a high speed reduction ratio; a control lever section operated by a user in controlling drive of the engine; and a control portion and an ECU controlling a shift between reduction ratios of the transmission mechanism based on operation of the control lever section by the user. The control portion and the ECU control a shift between reduction ratios of the transmission mechanism based on a transmission control map providing a reference for a shift between reduction ratios of the transmission mechanism taking into consideration an engine speed of the engine and a lever opening of the control lever section. This arrangement provides a marine propulsion system in which both acceleration performance and maximum speed can approach levels that a user desires.

摘要翻译： 船用推进系统包括：传动机构，其被设置成将发动机产生的驱动力传递给螺旋桨，其速度变为低速减速比和高减速比; 由用户操作的控制杆部分，用于控制发动机的驱动; 以及控制部分和ECU，其基于用户的控制杆部分的操作来控制传动机构的减速比之间的偏移。 控制部和ECU基于传动控制图来控制变速机构的减速比之间的变化，该变速控制图提供考虑到发动机的发动机转速和变速机构的杠杆开度之间的变速机构的减速比之间的偏移的基准 控制杆部分。 这种布置提供了一种船舶推进系统，其中加速性能和最大速度均可达到用户期望的水平。

公开(公告)号：US20110273538A1

公开(公告)日：2011-11-10

申请号：US13138215

申请日：2009-08-26

申请人： Takayoshi Suzuki

发明人： Takayoshi Suzuki

IPC分类号： H04N13/02

CPC分类号： A61B3/12 ,  A61B3/132 ,  A61B3/14 ,  G06T2207/10012 ,  G06T2207/30041

摘要： A light beam reflected from an ocular fundus 1a is split into a pair of right and left light beams by a two-aperture stop 31 disposed in a position conjugate with an anterior ocular segment 1b of an eye 1 to be examined. The pair of right and left ocular fundus images having a parallax is formed as intermediate images from the split light beams at the position of a photographic mask 43. The optical path of the pair of ocular fundus images formed as intermediate images is split by a pair of optical path splitting lenses 51, 52 disposed in a position substantially conjugate with the two-aperture stop. One ocular fundus image is re-formed on half of an imaging plane 53a of an imaging element 53, and the other ocular fundus image is re-formed separately on the other half of the imaging plane. With such a structure, two ocular fundus images for three-dimensional viewing can be efficiently obtained without using a prism for splitting the optical path.

摘要翻译： 从眼底1a反射的光束通过设置在与待检查的眼睛1的前眼部段1b共轭的位置的双孔径光阑31分成一对左右光束。 具有视差的一对右眼和左眼眼底图像被形成为在照相掩模43的位置处的分割光束的中间图像。形成为中间图像的一对眼底图像的光路被一对分开 的光路分离透镜51,52设置在与双孔径光阑大致共轭的位置。 在成像元件53的成像平面53a的一半上重新形成一个眼底图像，另一个眼底图像在成像平面的另一半上单独重新形成。 利用这种结构，可以有效地获得用于三维观看的两个眼底图像而不使用用于分割光路的棱镜。

公开(公告)号：US08038489B2

公开(公告)日：2011-10-18

申请号：US12427810

申请日：2009-04-22

申请人： Takayoshi Suzuki ,  Hideaki Matsushita ,  Daisuke Nakamura ,  Tsugunori Konakawa

发明人： Takayoshi Suzuki ,  Hideaki Matsushita ,  Daisuke Nakamura ,  Tsugunori Konakawa

IPC分类号： B63H21/21

CPC分类号： B63H21/213 ,  F16H61/16 ,  Y10T74/20396

摘要： An outboard motor includes a prime mover, a marine propulsion unit having a propeller arranged to be driven by a rotational force of the prime mover to generate a thrust force, a shift position changing mechanism, a shift position changing mechanism actuator, and a control unit arranged to control the shift position changing mechanism actuator. When the shift position is changed to one of the first shift position and the second shift position from the neutral position, the control unit inhibits a change in the shift position to the other one of the first shift position and the second shift position until a predetermined time period elapses. The above arrangement improves the controllability of a boat propulsion system having an electronically controlled shift mechanism.

摘要翻译： 舷外马达包括原动机，具有螺旋桨的船用推进单元，该螺旋桨布置成由原动机的旋转力驱动以产生推力，换挡位置改变机构，换挡位置改变机构致动器和控制单元 布置成控制换档位置改变机构致动器。 当变速位置从中立位置变为第一变速位置和第二变速位置之一时，控制单元禁止变速位置相对于第一变速位置和第二变速位置中的另一位置的变化，直到预定 时间过去了。 上述布置提高了具有电子控制的换档机构的船舶推进系统的可控性。

公开(公告)号：US07762859B2

公开(公告)日：2010-07-27

申请号：US12389436

申请日：2009-02-20

申请人： Takayoshi Suzuki ,  Daisuke Nakamura

发明人： Takayoshi Suzuki ,  Daisuke Nakamura

IPC分类号： B63H23/00

CPC分类号： B63H23/30 ,  B63H1/18 ,  B63H21/213 ,  B63H23/08

摘要： A propulsion system for a boat includes propellers arranged to be rotated by an engine, a transmission mechanism arranged to transmit driving force of the engine to the propellers such that a speed of the driving force of the engine is changed at least with a gear reduction ratio for low speed and high speed, and a control unit arranged to output a signal to control a gear shift in the transmission mechanism on the basis of an amount of lever opening, which is based on operation of a control lever section, and speed of the engine, and the control unit being arranged to detect cavitation generated in conjunction with rotation of the propellers on the basis of a gear shift control map. The control unit is arranged to control output of a signal to the transmission mechanism for changing a reduction gear to that for high speed when cavitation is detected.

摘要翻译： 用于船的推进系统包括布置成由发动机旋转的螺旋桨，传动机构，其布置成将发动机的驱动力传递到螺旋桨，使得发动机的驱动力的速度至少以齿轮减速比改变 用于低速和高速的控制单元，以及控制单元，其布置成基于基于控制杆部分的操作的杠杆开度的量输出信号以控制变速机构中的档位，并且速度 发动机，并且所述控制单元被布置成基于变速控制图检测结合所述螺旋桨的旋转而产生的气蚀。 控制单元被布置成当检测到空化时，控制到传动机构的信号的输出以将减速齿轮改变为高速。