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1.发明授权公开(公告)号：US08309574B2
公开(公告)日：2012-11-13
申请号：US10590493
申请日：2005-02-24
IPC分类号： A61K31/47
CPC分类号： G01N33/6872 , A61K31/51 , A61K45/06 , G01N2333/4719 , A61K2300/00
摘要： A nuclear transfer promoter for Rac protein comprising an isoprenoid synthesis inhibitor and/or a geranylgeranyl transferase inhibitor such as an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, an AMPK activator or a farnesyl pyrophosphoric acid synthase preparation; utilization thereof; a method therefor; a blood vessel remedy comprising the nuclear transfer promoter for Rac protein as the active ingredient; and a method of screening a blood vessel remedy which comprises assaying the ability of Rac protein to transfer into nucleus.
摘要翻译： 包含类异戊二烯合成抑制剂和/或香叶基香叶基转移酶抑制剂如HMG-CoA合成酶抑制剂，HMG-CoA还原酶抑制剂，AMPK激活剂或法呢基焦磷酸合成酶的Rac蛋白的核转移启动子; 使用; 一种方法; 包括用于Rac蛋白的核转移启动子作为活性成分的血管补救剂; 以及筛选血管补救的方法，其包括测定Rac蛋白转移入细胞核的能力。
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2.发明授权Method of screening pharmaceutical compositions that promote nuclear transfer of Cdc42 protein 有权筛选促进Cdc42蛋白核转移的药物组合物的方法公开(公告)号：US08252524B2
公开(公告)日：2012-08-28
申请号：US12548239
申请日：2009-08-26
IPC分类号： C12Q1/00
CPC分类号： A61K45/06 , A61K31/51 , A61K2300/00
摘要： A nuclear transfer promoter for Cdc42 protein comprising an isoprenoid synthesis inhibitor and/or a geranylgeranyl transferase inhibitor such as an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, an AMPK activator or a farnesyl pyrophosphoric acid synthase preparation; utilization thereof; a method therefor; a blood vessel remedy comprising the nuclear transfer promoter for Cdc42 protein as the active ingredient; and a method of screening a blood vessel remedy which comprises assaying the ability of Cdc42 protein to transfer into nucleus.
摘要翻译： 包含类异戊二烯合成抑制剂和/或香叶基香叶基转移酶抑制剂如HMG-CoA合成酶抑制剂，HMG-CoA还原酶抑制剂，AMPK活化剂或法呢基焦磷酸合成酶的Cdc42蛋白的核转移启动子; 使用; 一种方法; 包括Cdc42蛋白的核转移启动子作为活性成分的血管补救剂; 以及筛选血管补救的方法，其包括测定Cdc42蛋白转移到细胞核中的能力。
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3.发明申请Nuclear Transfer Promoter for Ddc42 Protein and Method of Screening the Dame 审中-公开Ddc42蛋白的核转移启动子和筛选方法公开(公告)号：US20070293535A1
公开(公告)日：2007-12-20
申请号：US10590492
申请日：2005-02-24
IPC分类号： A61K31/47 , A61P9/14 , C07D215/00 , C12N5/02 , G01N33/53
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/5064
摘要： A nuclear transfer promoter for Cdc42 protein comprising an isoprenoid synthesis inhibitor and/or a geranylgeranyl transferase inhibitor such as an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, an AMPK activator or a farnesyl pyrophosphoric acid synthase preparation; utilization thereof; a method therefor; a blood vessel remedy comprising the nuclear transfer promoter for Cdc42 protein as the active ingredient; and a method of screening a blood vessel remedy which comprises assaying the ability of Cdc42 protein to transfer into nucleus.
摘要翻译： 包含类异戊二烯合成抑制剂和/或香叶基香叶基转移酶抑制剂如HMG-CoA合成酶抑制剂，HMG-CoA还原酶抑制剂，AMPK活化剂或法呢基焦磷酸合成酶的Cdc42蛋白的核转移启动子; 使用; 一种方法; 包括Cdc42蛋白的核转移启动子作为活性成分的血管补救剂; 以及筛选血管补救的方法，其包括测定Cdc42蛋白转移到细胞核中的能力。
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公开(公告)号：US07526942B2
公开(公告)日：2009-05-05
申请号：US10560359
申请日：2004-06-04
IPC分类号： G01N33/00
CPC分类号： G01N27/16
摘要： A contact combustion-type gas sensor that can maintain its initial sensitivity over a long period of time in the presence of silicon vapor, wherein an induction portion 5 of a gas detecting element 1 contains not less than 30 percent by weight of an oxidation catalyst, and is aged in advance in an environment that contains silicon vapor serving as a poisoning substance.
摘要翻译： 一种接触式燃烧型气体传感器，其在硅蒸汽存在的情况下能够长期保持其初始灵敏度，其中气体检测元件1的诱导部分5含有不少于30重量％的氧化催化剂， 并且在含有作为中毒物质的硅蒸气的环境中预先熟化。
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5.发明申请NUCLEAR TRANSFER PROMOTER FOR Cdc42 PROTEIN AND METHOD OF SCREENING THE SAME 有权Cdc42蛋白的核转移促进剂及其筛选方法公开(公告)号：US20100221766A1
公开(公告)日：2010-09-02
申请号：US12548239
申请日：2009-08-26
IPC分类号： C12Q1/02
CPC分类号： A61K45/06 , A61K31/51 , A61K2300/00
摘要： A nuclear transfer promoter for Cdc42 protein comprising an isoprenoid synthesis inhibitor and/or a geranylgeranyl transferase inhibitor such as an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, an AMPK activator or a farnesyl pyrophosphoric acid synthase preparation; utilization thereof; a method therefor; a blood vessel remedy comprising the nuclear transfer promoter for Cdc42 protein as the active ingredient; and a method of screening a blood vessel remedy which comprises assaying the ability of Cdc42 protein to transfer into nucleus.
摘要翻译： 包含类异戊二烯合成抑制剂和/或香叶基香叶基转移酶抑制剂如HMG-CoA合成酶抑制剂，HMG-CoA还原酶抑制剂，AMPK活化剂或法呢基焦磷酸合成酶的Cdc42蛋白的核转移启动子; 使用; 一种方法; 包括Cdc42蛋白的核转移启动子作为活性成分的血管补救剂; 以及筛选血管补救的方法，其包括测定Cdc42蛋白转移到细胞核中的能力。
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6.发明申请公开(公告)号：US20070281967A1
公开(公告)日：2007-12-06
申请号：US10590493
申请日：2005-02-24
IPC分类号： A61K31/47 , A61P9/10 , C07D215/14 , C12Q1/02
CPC分类号： G01N33/6872 , A61K31/51 , A61K45/06 , G01N2333/4719 , A61K2300/00
摘要： A nuclear transfer promoter for Rac protein comprising an isoprenoid synthesis inhibitor and/or a geranylgeranyl transferase inhibitor such as an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, an AMPK activator or a farnesyl pyrophosphoric acid synthase preparation; utilization thereof; a method therefor; a blood vessel remedy comprising the nuclear transfer promoter for Rac protein as the active ingredient; and a method of screening a blood vessel remedy which comprises assaying the ability of Rac protein to transfer into nucleus.
摘要翻译： 包含类异戊二烯合成抑制剂和/或香叶基香叶基转移酶抑制剂如HMG-CoA合成酶抑制剂，HMG-CoA还原酶抑制剂，AMPK激活剂或法呢基焦磷酸合成酶的Rac蛋白的核转移启动子; 使用; 一种方法; 包括用于Rac蛋白的核转移启动子作为活性成分的血管补救剂; 以及筛选血管补救的方法，其包括测定Rac蛋白转移入细胞核的能力。
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