公开(公告)号：US08356607B2

公开(公告)日：2013-01-22

申请号：US13101210

申请日：2011-05-05

申请人： Yasunobu Inoue ,  Kiyohiro Sasakawa ,  Kazunori Sugai ,  Kenichi Nishimura ,  Yoshio Nakahara

发明人： Yasunobu Inoue ,  Kiyohiro Sasakawa ,  Kazunori Sugai ,  Kenichi Nishimura ,  Yoshio Nakahara

IPC分类号： A24D1/02

CPC分类号： A24B15/28 ,  A24B15/282 ,  A24B15/287 ,  A24B15/288 ,  A24D1/02 ,  B01J21/04 ,  B01J21/06 ,  B01J21/063 ,  B01J23/02 ,  B01J23/06 ,  B01J23/28 ,  B01J23/40 ,  B01J23/70 ,  B01J35/1009 ,  B01J35/1014 ,  B01J37/0036 ,  B01J37/0045 ,  B01J37/0201 ,  B01J37/0203 ,  B01J37/0215 ,  B01J37/0234 ,  B01J37/04 ,  B01J37/08

摘要： A smoking article includes a carbon monoxide reducing agent including particles including a calcium aluminate represented by the formula (CaO)m(Al2O3)n, where 1/6≦m/n≦4/1, wherein the particles have a BET specific surface area of 2 m2/g or more and less than 20 m2/g.

摘要翻译： 一种吸烟制品包括一氧化碳还原剂，其包括由式（CaO）m（Al 2 O 3）n表示的铝酸钙的颗粒，其中1/6＆lt; lE; m / n＆nlE; 4/1，其中所述颗粒具有BET比表面积 为2m 2 / g以上且小于20m 2 / g。

公开(公告)号：US08137964B2

公开(公告)日：2012-03-20

申请号：US11514468

申请日：2006-09-01

申请人： Mitsuru Akashi ,  Yoshiki Sawa ,  Michiya Matsusaki ,  Yoshio Nakahara

发明人： Mitsuru Akashi ,  Yoshiki Sawa ,  Michiya Matsusaki ,  Yoshio Nakahara

IPC分类号： C12N5/06

CPC分类号： C12N5/0068 ,  C12N5/0062 ,  C12N2533/52 ,  C12N2533/54 ,  Y10S977/902

摘要： The present invention provides a novel method of producing a three-dimensional tissue by which cell lamination can be carried out easily. According to the method, a three-dimensional tissue in which cell layers are laminated with an extracellular matrix intervening between each pair of the adjacent cell layers is produced by: (A) forming a cell layer on a substrate; (B) bringing the cell layer formed on the substrate into contact with a solution containing a first substance and a solution containing a second substance alternately, thus forming, on the cell layer, an extracellular matrix in which the first substance and the second substance are laminated alternately; and (C) culturing a cell on the extracellular matrix to form a further cell layer. In the present invention, a combination of the first substance and the second substance is (a) a combination of a protein or polymer having an RGD sequence and a protein or polymer that interacts with the protein or polymer having the RGD sequence or (b) a combination of a protein or polymer that is positively charged and a protein or polymer that is negatively charged.

摘要翻译： 本发明提供一种可以容易地进行细胞层压的三维组织的制造方法。 根据该方法，通过以下方法制造细胞层与介于每对相邻细胞层之间的细胞外基质层叠的三维组织：（A）在基材上形成细胞层; （B）使形成在基板上的细胞层与含有第一物质的溶液和含有第二物质的溶液交替接触，从而在细胞层上形成第一物质和第二物质为细胞外基质 交替叠层; 和（C）在细胞外基质上培养细胞以形成另外的细胞层。 在本发明中，第一物质和第二物质的组合是（a）具有RGD序列的蛋白质或聚合物和与具有RGD序列的蛋白质或聚合物相互作用的蛋白质或聚合物的组合，或（b） 带正电荷的蛋白质或聚合物和带负电荷的蛋白质或聚合物的组合。

公开(公告)号：US4756650A

公开(公告)日：1988-07-12

申请号：US935516

申请日：1986-11-26

申请人： Koichiro Wakihira ,  Michitaka Katsuta ,  Masayasu Hino ,  Kouhei Matsumoto ,  Yoshio Nakahara ,  Tosio Sasayama

发明人： Koichiro Wakihira ,  Michitaka Katsuta ,  Masayasu Hino ,  Kouhei Matsumoto ,  Yoshio Nakahara ,  Tosio Sasayama

IPC分类号： B23B51/02

CPC分类号： B23B51/02 ,  B23B2251/18 ,  B23B2251/241 ,  B23B2251/406 ,  Y10T408/909 ,  Y10T408/9097

摘要： A twist drill including a body characterized by the outer portion of each of the heels bulging toward the main flute as compared with that of the standard twist drill, the main lips each bulging in a triangular shape in cross section toward the main flute as compared with that of the standard twist drill, and a subflute having a substantially U-shaped cross section and axially formed in the inner portion adjacent to the axis of the twist drill of each of the heels along the main flute for a predetermined distance from the tip.

摘要翻译： 一种麻花钻，其特征在于，与标准麻花钻相比，每个高跟鞋的外侧部分均朝向主笛子的外侧部分突出，主唇部分朝向主笛子的横截面呈三角形，与 标准麻花钻，以及具有大致U形横截面的子抽头，并且沿着主笛子轴向地形成在与每个脚踝的麻花钻的轴线相邻的内部中距离尖端预定距离。

公开(公告)号：US20110203599A1

公开(公告)日：2011-08-25

申请号：US13101210

申请日：2011-05-05

申请人： Yasunobu Inoue ,  Kiyohiro Sasakawa ,  Kazunori Sugai ,  Kenichi Nishimura ,  Yoshio Nakahara

发明人： Yasunobu Inoue ,  Kiyohiro Sasakawa ,  Kazunori Sugai ,  Kenichi Nishimura ,  Yoshio Nakahara

IPC分类号： A24D3/16 ,  A24C5/52

CPC分类号： A24B15/28 ,  A24B15/282 ,  A24B15/287 ,  A24B15/288 ,  A24D1/02 ,  B01J21/04 ,  B01J21/06 ,  B01J21/063 ,  B01J23/02 ,  B01J23/06 ,  B01J23/28 ,  B01J23/40 ,  B01J23/70 ,  B01J35/1009 ,  B01J35/1014 ,  B01J37/0036 ,  B01J37/0045 ,  B01J37/0201 ,  B01J37/0203 ,  B01J37/0215 ,  B01J37/0234 ,  B01J37/04 ,  B01J37/08

摘要： A smoking article includes a carbon monoxide reducing agent including particles including a calcium aluminate represented by the formula (CaO)m(Al2O3)n, where 1/6≦m/n≦4/1, wherein the particles have a BET specific surface area of 2 m2/g or more and less than 20 m2/g.

摘要翻译： 一种吸烟制品包括一氧化碳还原剂，其包括由式（CaO）m（Al 2 O 3）n表示的铝酸钙的颗粒，其中1/6＆lt; lE; m / n＆nlE; 4/1，其中所述颗粒具有BET比表面积 为2m 2 / g以上且小于20m 2 / g。

公开(公告)号：US20070207540A1

公开(公告)日：2007-09-06

申请号：US11514468

申请日：2006-09-01

申请人： Mitsuru Akashi ,  Yoshiki Sawa ,  Michiya Matsusaki ,  Yoshio Nakahara

发明人： Mitsuru Akashi ,  Yoshiki Sawa ,  Michiya Matsusaki ,  Yoshio Nakahara

IPC分类号： C12N5/06

CPC分类号： C12N5/0068 ,  C12N5/0062 ,  C12N2533/52 ,  C12N2533/54 ,  Y10S977/902

摘要： The present invention provides a novel method of producing a three-dimensional tissue by which cell lamination can be carried out easily. According to the method, a three-dimensional tissue in which cell layers are laminated with an extracellular matrix intervening between each pair of the adjacent cell layers is produced by: (A) forming a cell layer on a substrate; (B) bringing the cell layer formed on the substrate into contact with a solution containing a first substance and a solution containing a second substance alternately, thus forming, on the cell layer, an extracellular matrix in which the first substance and the second substance are laminated alternately; and (C) culturing a cell on the extracellular matrix to form a further cell layer. In the present invention, a combination of the first substance and the second substance is (a) a combination of a protein or polymer having an RGD sequence and a protein or polymer that interacts with the protein or polymer having the RGD sequence or (b) a combination of a protein or polymer that is positively charged and a protein or polymer that is negatively charged.

摘要翻译： 本发明提供一种可以容易地进行细胞层压的三维组织的制造方法。 根据该方法，通过以下方法制造细胞层与介于每对相邻细胞层之间的细胞外基质层叠的三维组织：（A）在基材上形成细胞层; （B）使形成在基板上的细胞层与含有第一物质的溶液和含有第二物质的溶液交替接触，从而在细胞层上形成第一物质和第二物质为细胞外基质 交替叠层; 和（C）在细胞外基质上培养细胞以形成另外的细胞层。 在本发明中，第一物质和第二物质的组合是（a）具有RGD序列的蛋白质或聚合物和与具有RGD序列的蛋白质或聚合物相互作用的蛋白质或聚合物的组合，或（b） 带正电荷的蛋白质或聚合物和带负电荷的蛋白质或聚合物的组合。