公开(公告)号：US06573371B2

公开(公告)日：2003-06-03

申请号：US09879833

申请日：2001-06-12

申请人： Neon-Cheol Jung ,  Jin-Man Kim ,  Seung-Suh Hong ,  Hyun-Soo Lee ,  Young-Rim Seong ,  Jae-Ho Lee

发明人： Neon-Cheol Jung ,  Jin-Man Kim ,  Seung-Suh Hong ,  Hyun-Soo Lee ,  Young-Rim Seong ,  Jae-Ho Lee

IPC分类号： C07H2102

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to a diagnosis method of cancer using SYG972 gene and to the genomic DNA and to a promoter regulating transcription of the gene. Expression of SYG972 gene is greatly reduced in breast cancer cells compared to normal breast cells. Therefore the present invention provides a method of diagnosis method by using the gene of the present invention or its fragments as a probe. SYG972 genomic according to the present invention is composed of 4 exons and 3 introns. Promoter is 3 kb long from the transcription initiating site in the 5′ direction. SYG972 genomic DNA and promoter can be used to design and screen drugs to promote or to inhibit apoptosis and differentiation of cells, especially to screen drugs to treat cancer, a disease wherein cell growth and differentiation is abnormal.

摘要翻译： 本发明涉及使用SYG972基因和基因组DNA的癌症诊断方法以及调节基因转录的启动子。 与正常乳腺细胞相比，乳腺癌细胞中SYG972基因的表达大大降低。 因此，本发明提供了通过使用本发明的基因或其片段作为探针的诊断方法。 根据本发明的SYG972基因组由4个外显子和3个内含子组成。 启动子距5'方向的转录起始位点长3 kb。 SYG972基因组DNA和启动子可用于设计和筛选药物，以促进或抑制细胞的凋亡和分化，特别是筛选药物以治疗癌症，其中细胞生长和分化异常。