公开(公告)号：US08084054B2

公开(公告)日：2011-12-27

申请号：US10610090

申请日：2003-06-30

Applicant: Bhagwati P. Kabra ,  Janet D. Howie ,  Youqin Tian ,  David Allen Marsh ,  Gustav Graff

Inventor： Bhagwati P. Kabra ,  Janet D. Howie ,  Youqin Tian ,  David Allen Marsh ,  Gustav Graff

IPC: A61F2/00

CPC classification number: A61K9/0051 ,  A61K9/1617 ,  A61K9/7007 ,  A61K31/337

Abstract: Drug delivery film compositions containing a combination of a water-soluble, film-forming polymers and a fatty acid glyceride or ester are suitable for delivering ophthalmic drugs.

Abstract translation: 含有水溶性，成膜聚合物和脂肪酸甘油酯或酯的组合的药物递送膜组合物适用于输送眼用药物。

公开(公告)号：US08158609B1

公开(公告)日：2012-04-17

申请号：US11934132

申请日：2007-11-02

Applicant: David Allen Marsh ,  Robert J. Collier, Jr. ,  Michael A. Kapin ,  Youqin Tian ,  Eliot Mark Slovin

Inventor： David Allen Marsh ,  Robert J. Collier, Jr. ,  Michael A. Kapin ,  Youqin Tian ,  Eliot Mark Slovin

IPC: A61K31/724

CPC classification number: A61K31/724 ,  A61K9/0048 ,  A61K47/40

Abstract: The present invention is directed to the treatment of disorders involving the accumulation of drusen, such as dry age-related macular degeneration and geographic atrophy via administration of therapeutically effective amounts of at least one monomeric or polymeric cyclodextrin.

Abstract translation: 本发明涉及通过施用治疗有效量的至少一种单体或聚合物环糊精来治疗涉及玻璃疣累积的疾病，例如干年龄相关性黄斑变性和地理性萎缩。

公开(公告)号：US20080181930A1

公开(公告)日：2008-07-31

申请号：US12022520

申请日：2008-01-30

Applicant: Theron R. Rodstrom ,  Larry Smith ,  Youqin Tian ,  David Allen Marsh ,  Alan L. Weiner ,  Shivalik Bakshi

Inventor： Theron R. Rodstrom ,  Larry Smith ,  Youqin Tian ,  David Allen Marsh ,  Alan L. Weiner ,  Shivalik Bakshi

IPC: A61F2/14 ,  A61K31/343

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/00781

Abstract: The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.

Abstract translation: 本发明涉及用于向眼睛持续释放药物的可植入眼部装置以及用于制造和使用这些装置的方法。 在一个实施方案中，本发明提供了一种装置，其包括：（a）包含前列腺素和硅氧烷的基质的主体; （b）主体外表面上的聚对二甲苯涂层; 和（c）从聚对二甲苯涂层的外表面延伸到主体的外表面的一个或多个孔。

公开(公告)号：US08753666B2

公开(公告)日：2014-06-17

申请号：US12022520

申请日：2008-01-30

Applicant: Theron R. Rodstrom ,  Larry Smith, II ,  Youqin Tian ,  David Allen Marsh ,  Alan L. Weiner ,  Shivalik Bakshi

Inventor： Theron R. Rodstrom ,  Larry Smith, II ,  Youqin Tian ,  David Allen Marsh ,  Alan L. Weiner ,  Shivalik Bakshi

IPC: A61F2/00 ,  A61K9/14 ,  A61K51/00 ,  A61M36/14

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F9/00781

Abstract: The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.

Abstract translation: 本发明涉及用于向眼睛持续释放药物的可植入眼部装置以及用于制造和使用这些装置的方法。 在一个实施方案中，本发明提供了一种装置，其包括：（a）包含前列腺素和硅氧烷的基质的主体; （b）主体外表面上的聚对二甲苯涂层; 和（c）从聚对二甲苯涂层的外表面延伸到主体的外表面的一个或多个孔。

公开(公告)号：US06197344B1

公开(公告)日：2001-03-06

申请号：US09429391

申请日：1999-10-28

Applicant: Hung-Chih Chang ,  Lukchiu Li ,  Youqin Tian

Inventor： Hung-Chih Chang ,  Lukchiu Li ,  Youqin Tian

IPC: A61K914

CPC classification number: A61K47/44 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  Y10S514/938 ,  Y10S514/964

Abstract: Controlled, sustained release formulations of butorphanol are provided. Such formulations can be an aqueous suspension of butorphanol freebase or an oil suspension of a butorphanol salt. Processes for using such formulations to provide long term analgesia are also provided.

Abstract translation: 提供了对照的持续释放配方丁哌醇。 这样的制剂可以是布托啡诺游离碱的水悬浮液或布可诺盐的油悬浮液。 还提供了使用这些制剂提供长期止痛的方法。