公开(公告)号：US08084054B2

公开(公告)日：2011-12-27

申请号：US10610090

申请日：2003-06-30

Applicant: Bhagwati P. Kabra ,  Janet D. Howie ,  Youqin Tian ,  David Allen Marsh ,  Gustav Graff

Inventor： Bhagwati P. Kabra ,  Janet D. Howie ,  Youqin Tian ,  David Allen Marsh ,  Gustav Graff

IPC: A61F2/00

CPC classification number: A61K9/0051 ,  A61K9/1617 ,  A61K9/7007 ,  A61K31/337

Abstract: Drug delivery film compositions containing a combination of a water-soluble, film-forming polymers and a fatty acid glyceride or ester are suitable for delivering ophthalmic drugs.

Abstract translation: 含有水溶性，成膜聚合物和脂肪酸甘油酯或酯的组合的药物递送膜组合物适用于输送眼用药物。

公开(公告)号：US20060257486A1

公开(公告)日：2006-11-16

申请号：US11429736

申请日：2006-05-08

Applicant: Geoffrey Owen ,  Amy Brooks ,  Gustav Graff

Inventor： Geoffrey Owen ,  Amy Brooks ,  Gustav Graff

IPC: A61K9/14

CPC classification number: A61K31/57 ,  A61K9/0048 ,  A61K9/10 ,  A61K31/165 ,  A61K31/542

Abstract: Topical aqueous suspension compositions of sparingly soluble ophthalmic drugs are disclosed. The compositions comprise a combination of a poloxamine nonionic surfactant and a glycol tonicity-adjusting agent such as propylene glycol.

Abstract translation: 公开了微溶眼药物的局部水性悬浮液组合物。 组合物包含泊洛沙胺非离子表面活性剂和二醇张力调节剂如丙二醇的组合。

公开(公告)号：US20050143468A1

公开(公告)日：2005-06-30

申请号：US10511414

申请日：2003-04-16

Applicant: David Bingaman ,  Michael Kapin ,  Daniel Gamache ,  Gustav Graff ,  John Yanni

Inventor： David Bingaman ,  Michael Kapin ,  Daniel Gamache ,  Gustav Graff ,  John Yanni

IPC: A61P9/00 ,  A61K31/195 ,  A61K31/196 ,  A61P9/10 ,  A61P27/02 ,  A61P27/06

CPC classification number: A61K31/196

Abstract: The use of amfenac and derivatives, including nepafenac, to treat vascular endothelial growth factor mediated vascular disorders.

Abstract translation: 使用阿芬酸及其衍生物，包括奈帕非尼治疗血管内皮生长因子介导的血管疾病。

公开(公告)号：US06638976B2

公开(公告)日：2003-10-28

申请号：US09929704

申请日：2001-08-13

Applicant: Daniel A. Gamache ,  Gustav Graff ,  John M. Yanni ,  Michael A. Kapin

Inventor： Daniel A. Gamache ,  Gustav Graff ,  John M. Yanni ,  Michael A. Kapin

IPC: A61K31216

CPC classification number: A61K31/24 ,  A61K31/165 ,  A61K31/195 ,  A61K31/196

Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.

公开(公告)号：US06433007B1

公开(公告)日：2002-08-13

申请号：US09830833

申请日：2001-05-01

Applicant: Wiliam H. Garner ,  Gustav Graff

Inventor： Wiliam H. Garner ,  Gustav Graff

IPC: A61K3135

CPC classification number: A61K31/353 ,  A61K31/343 ,  A61K31/35 ,  A61K47/545 ,  A61K47/555 ,  Y10S514/912

Abstract: Methods for treating post-surgical formation of cataracts or posterior capsule opacification are disclosed. The methods utilize compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by and amide and ester bond.

Abstract translation: 公开了治疗手术后形成白内障或后囊不透明的方法。 该方法利用含有具有共价连接的酰胺和酯键的抗炎和抗氧化部分的某些化合物的组合物。

公开(公告)号：US6001128A

公开(公告)日：1999-12-14

申请号：US86883

申请日：1998-05-29

Applicant: Gustav Graff ,  Mutlu Karakelle ,  John W. Sheets, Jr. ,  John M. Yanni

Inventor： Gustav Graff ,  Mutlu Karakelle ,  John W. Sheets, Jr. ,  John M. Yanni

IPC: A61L31/00 ,  A61L31/04 ,  A61F2/16

CPC classification number: A61L31/048 ,  Y10S623/901

Abstract: Improved glaucoma filtration device materials comprise at least one monomer having the formula: ##STR1## wherein: X is H or CH.sub.3 ;m is 0-10;Y is nothing, O, or S;R is nothing, H, or an aliphatic, aromatic or aliphatic/aromatic combination of up to twelve carbon atoms, which can be unsubstituted or substituted with Cl, F, Br, or an alkoxy of up to four carbon atoms; anda cross-linking monomer having two or more ethylenically unsaturated groups.

Abstract translation: 改善的青光眼过滤装置材料包含至少一种具有下式的单体：其中：X是H或CH3; m为0-10; Y不是O，或S; R不能是H，或至多12个碳原子的脂族，芳族或脂族/芳族组合，其可以是未取代的或被Cl，F，Br或最多四个碳原子的烷氧基取代; 和具有两个以上烯属不饱和基团的交联单体。

公开(公告)号：US5607966A

公开(公告)日：1997-03-04

申请号：US362718

申请日：1994-12-23

Applicant: Mark R. Hellberg ,  Gustav Graff

Inventor： Mark R. Hellberg ,  Gustav Graff

IPC: A61K31/343 ,  A61K31/353 ,  A61K31/355 ,  C07C235/34 ,  C07D307/80 ,  C07D311/72 ,  C07D311/04 ,  A01K31/35

CPC classification number: A61K31/355 ,  A61K31/343 ,  A61K31/353 ,  A61K47/48061 ,  C07C235/34 ,  C07D307/80 ,  C07D311/72

Abstract: Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.

Abstract translation: 公开了具有抗炎和抗氧化活性的化合物。 该化合物可用于通过几种机制预防和治疗炎症性疾病。 公开了使用这些化合物和相应药物组合物性质的治疗方法。

公开(公告)号：US20060257487A1

公开(公告)日：2006-11-16

申请号：US11430239

申请日：2006-05-08

Applicant: Geoffrey Owen ,  Amy Brooks ,  Gustav Graff

Inventor： Geoffrey Owen ,  Amy Brooks ,  Gustav Graff

IPC: A61K9/14 ,  A61K31/165

CPC classification number: A61K31/165 ,  A61K9/0048 ,  A61K9/10 ,  A61K31/542 ,  A61K31/57

Abstract: Topical aqueous suspension compositions of sparingly soluble ophthalmic drugs are disclosed. The compositions comprise a combination of a poloxamer or meroxapol surfactant and a glycol tonicity-adjusting agent such as propylene glycol.

Abstract translation: 公开了微溶眼药物的局部水性悬浮液组合物。 组合物包含泊洛沙姆或meroxapol表面活性剂和二醇张力调节剂如丙二醇的组合。

公开(公告)号：US06645978B1

公开(公告)日：2003-11-11

申请号：US09787789

申请日：2001-03-23

Applicant: Daniel A. Gamache ,  Gustav Graff ,  Mark R. Hellberg ,  Peter G. Klimko ,  John M. Yanni

Inventor： Daniel A. Gamache ,  Gustav Graff ,  Mark R. Hellberg ,  Peter G. Klimko ,  John M. Yanni

IPC: A61K900

CPC classification number: A61K31/202 ,  A61K9/0048 ,  A61K31/557 ,  Y10S514/822 ,  Y10S514/925 ,  Y10S514/947 ,  Y10S514/954

Abstract: Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.

Abstract translation: 公开了含有Lipoxin A4及其类似物的眼科组合物及其用于治疗干燥前夕的方法。

公开(公告)号：US06399107B1

公开(公告)日：2002-06-04

申请号：US09868741

申请日：2001-06-20

Applicant: Timothy L. Kessler ,  Jon C. Nixon ,  Karen C. David ,  Gustav Graff

Inventor： Timothy L. Kessler ,  Jon C. Nixon ,  Karen C. David ,  Gustav Graff

IPC: A61K3326

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/352 ,  A61K31/553 ,  A61K33/24 ,  Y10S514/912 ,  A61K2300/00

Abstract: This invention relates to the compositions and methods for the treatment of corneal haze. The compositions and methods are particularly directed to the use of GAG synthesis inhibitors in the treatment of corneal haze.

Abstract translation: 本发明涉及治疗角膜混浊的组合物和方法。 组合物和方法特别涉及GAG合成抑制剂在治疗角膜混浊中的用途。