公开(公告)号：US4083881A

公开(公告)日：1978-04-11

申请号：US749623

申请日：1976-12-13

申请人： Motohiro Takemura ,  Mochihiro Iijima ,  Yoshiaki Tateno ,  Yuji Osada ,  Hiroyuki Maruyama

发明人： Motohiro Takemura ,  Mochihiro Iijima ,  Yoshiaki Tateno ,  Yuji Osada ,  Hiroyuki Maruyama

IPC分类号： C12P19/24 ,  B01J23/00 ,  B01J25/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C31/26 ,  C07C67/00 ,  C07H1/00 ,  C07H3/02 ,  C12P7/18 ,  C07C29/00

CPC分类号： C07C31/26 ,  C07H3/02

摘要： A D-glucose solution is added molybdic acid compound thereto and heated at a temperature of 110.degree.-160.degree. C with pH 2.0-4.5 to perform epimerizing reaction of D-glucose, and thereby 30-36%, based on the D-glucose, of D-mannose is formed. To the epimerized mixture thus obtained is further added glucose-isomerase to perform enzymatic isomerizing reaction of D-glucose remaining in the epimerized mixture, thereby 46% based on the remaining D-glucose is converted into D-fructose. The epimerized mixture or enzymatically isomerized mixture is subjected to catalytic hydrogenation under high pressure, and thereby is produced D-mannitol at high yield based on the initial D-glucose.

摘要翻译： 向D-葡萄糖溶液中加入钼酸化合物，在110〜160℃的温度下，用pH2.0〜4.5进行加热，以进行D-葡萄糖的差向异构化反应，从而基于D-葡萄糖进行30-36％ 的D-甘露糖。 向得到的差向异构体混合物中进一步添加葡萄糖异构酶，进行残留在差向异构化混合物中的D-葡萄糖的酶促异构化反应，由此将剩余D-葡萄糖的46％转化为D-果糖。 将差向异构化的混合物或酶促异构化的混合物在高压下进行催化氢化，从而基于初始D-葡萄糖以高产率生产D-甘露糖醇。

公开(公告)号：US5873943A

公开(公告)日：1999-02-23

申请号：US643157

申请日：1996-05-02

申请人： Mitsuo Magara ,  Koichi Kataura ,  Yoshiaki Tateno ,  Yoshimasa Onuki ,  Yuji Osada ,  Fumito Yamazaki ,  Kazuaki Kato

发明人： Mitsuo Magara ,  Koichi Kataura ,  Yoshiaki Tateno ,  Yoshimasa Onuki ,  Yuji Osada ,  Fumito Yamazaki ,  Kazuaki Kato

IPC分类号： C13K13/00 ,  A23L27/30 ,  B01D9/02 ,  B01D15/08 ,  C07H15/04 ,  C08B30/00 ,  C07G17/00 ,  C13F1/02 ,  C13K1/06

CPC分类号： C07H15/04

摘要： To provide an economically advantageous process for manufacturing crystalline maltitol and crystalline mixture solid containing crystalline maltitol. The process of this invention uses the syrup having a maltose purity of 81 to 90% as the starting material. The syrup is hydrogenated under the existence of catalyst, and then subjected to a chromatographic separation by using cation-exchange resin, resulting in an aqueous solution of maltitol having a maltitol purity of 94 to 99.9%. The aqueous solution, is further crystallized in the presence of a seed crystal, subjected to a separation, cooled and kneaded so as to manufacture both crystalline maltitol and crystalline mixture solid containing crystalline maltitol at the same time.

摘要翻译： 提供用于制造结晶麦芽糖醇和含有结晶麦芽糖醇的结晶混合物固体的经济上有利的方法。 本发明的方法使用麦芽糖纯度为81〜90％的浆料作为原料。 在催化剂存在下将糖浆氢化，然后通过使用阳离子交换树脂进行色谱分离，得到麦芽糖醇纯度为94-99.9％的麦芽糖醇水溶液。 水溶液在晶种存在下进一步结晶，进行分离，冷却和捏合，以同时制造含有结晶麦芽糖醇的结晶麦芽糖醇和结晶混合物固体。