公开(公告)号：US5153003A

公开(公告)日：1992-10-06

申请号：US425367

申请日：1989-10-18

申请人： Kozo Kurihara ,  Hironobu Saito ,  Yukie Misho ,  Takeshi Oshima

发明人： Kozo Kurihara ,  Hironobu Saito ,  Yukie Misho ,  Takeshi Oshima

IPC分类号： A61L33/00

CPC分类号： A61L33/0041 ,  Y10S514/822 ,  Y10S514/953

摘要： A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): ##STR1## (in which R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents a C.sub.3 -C.sub.12 alkyl group or a C.sub.3 -C.sub.12 alkenyl group; and n is an integer from 1 to 5; and pharmaceutically acceptable salts thereof) can be used to make a medical appliance from which the prostaglandin, having antithrombotic properties, will be released gradually and in a controlled way.