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    Protein matrix materials, devices and methods of making and using thereof
    2.
    发明授权
    Protein matrix materials, devices and methods of making and using thereof 有权
    蛋白质基质材料，其制备和使用方法

    公开(公告)号：US07662409B2

    公开(公告)日：2010-02-16

    申请号：US09796170

    申请日：2001-02-28

    申请人： David B. Masters

    发明人： David B. Masters

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/42

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/7007 ,  A61K47/42 ,  A61L27/227 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/622 ,  Y10S514/95 ,  Y10S514/953 ,  Y10S514/955 ,  Y10S514/964 ,  Y10S623/915 ,  C08L89/00

    摘要： The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

    摘要翻译： 本发明涉及蛋白质基质材料和装置，以及制备和使用蛋白质基质材料和装置的方法。 更具体地，本发明涉及可用于各种医学应用的蛋白质基质材料和装置，包括但不限于用于药理学活性剂的控制释放的药物递送装置，包封的或涂覆的支架装置，血管，管状移植物， 血管移植物，伤口愈合装置，包括蛋白质基质缝合材料和网眼，皮肤/骨/组织移植物，生物相容导电基质，透明蛋白质基质，蛋白质基质粘附防止屏障，细胞支架和其他生物相容性蛋白质基质装置。 此外，本发明涉及通过形成包含一种或多种可生物降解的蛋白质材料，一种或多种生物相容性溶剂和任选的一种或多种药理学活性剂的膜制备的蛋白质基质材料和装置。 然后将膜部分干燥，滚动或以其他方式成形，然后压缩以形成所需的蛋白质基质装置。

    Otorhinological delivery device
    5.
    发明申请
    Otorhinological delivery device 有权
    耳道输送装置

    公开(公告)号：US20060067982A1

    公开(公告)日：2006-03-30

    申请号：US10542420

    申请日：2004-01-14

    申请人： Timo Haapakumpu ,  Harri Jukarainen ,  Juha Ala-Sorvari ,  Frederik Riphagen ,  Wolfgang Arnold

    发明人： Timo Haapakumpu ,  Harri Jukarainen ,  Juha Ala-Sorvari ,  Frederik Riphagen ,  Wolfgang Arnold

    IPC分类号： A61F11/00

    CPC分类号： A61K9/0046 ,  A61K9/0043 ,  A61L31/06 ,  A61L31/16 ,  Y10S514/953 ,  C08L83/04

    摘要： The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.

    摘要翻译： 本发明涉及包含至少一种药物活性剂的运输装置。 根据本发明，该装置包括一种包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含3,3,3-三氟丙基 连接到硅氧烷单元的硅原子的基团，包含聚（环氧烷）基团的硅氧烷基弹性体及其混合物，以及包围所述芯的膜，所述膜由与所述芯相同或不同的弹性体组合物制成，所述 弹性体组合物选自聚（二甲基硅氧烷），包含连接到硅氧烷单元的硅原子上的3,3,3-三氟丙基的硅氧烷基弹性体，包含聚（氧化烯）基团的硅氧烷基弹性体和 其混合物。 本发明的特征在于药物活性剂选自抗过敏剂，抗炎剂，抗真菌剂，糖皮质激素及其混合物。

    Agricultural items and agricultural methods comprising biodegradable copolymers
    8.
    发明授权
    Agricultural items and agricultural methods comprising biodegradable copolymers 失效
    包括可生物降解共聚物的农产品和农业方法

    公开(公告)号：US06903053B2

    公开(公告)日：2005-06-07

    申请号：US10309997

    申请日：2002-12-04

    申请人： Isao Noda ,  Michael Matthew Satkowski

    发明人： Isao Noda ,  Michael Matthew Satkowski

    IPC分类号： A01N25/10 ,  C05G5/00

    CPC分类号： C08G63/06 ,  A01N25/10 ,  Y10S514/95 ,  Y10S514/953

    摘要： An agricultural item comprising a biodegradable polyhydroxyalkanoate copolymer comprising two randomly repeating monomer units. The first randomly repeating monomer unit has the structure: wherein R1 is H or a C1-2 alkyl, and n is 1 or 2; and the second randomly repeating monomer unit has the structure: wherein R2 is a C3-19 alkyl or a C3-19 alkenyl. At least 50% of the randomly repeating monomer units have the structure of the first randomly repeating monomer unit.

    摘要翻译： 一种农业物品，其包含可生物降解的聚羟基链烷酸酯共聚物，其包含两个随机重复的单体单元。 第一个随机重复的单体单元具有以下结构：其中R 1是H或C 1-12烷基，n是1或2; 并且第二个随机重复的单体单元具有以下结构：其中R 2是C 3〜19 - 烷基或C 3〜19 - 烯基。 至少50％的随机重复单体单元具有第一个无规重复的单体单元的结构。