公开(公告)号：US4533562A

公开(公告)日：1985-08-06

申请号：US601736

申请日：1984-04-19

申请人： Yoshihiko Ikegami ,  Kozo Kurihara ,  Izuo Ichikawa ,  Hisanori Nakane

发明人： Yoshihiko Ikegami ,  Kozo Kurihara ,  Izuo Ichikawa ,  Hisanori Nakane

IPC分类号： A61K9/00 ,  A61K9/28 ,  A61K9/30 ,  A61K9/50 ,  B01J2/00 ,  C08L1/32

CPC分类号： A61K9/5073 ,  A61K9/284 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/282

摘要： Solid materials, especially pharmaceutical preparations, are coated, without the use of solvents, with a powdered film-forming polymer and with a liquid plasticizer having an affinity for the polymer.

摘要翻译： 固体材料，特别是药物制剂，在不使用溶剂的情况下用粉末成膜聚合物和与聚合物具有亲和性的液体增塑剂进行涂布。

公开(公告)号：US4341563A

公开(公告)日：1982-07-27

申请号：US148172

申请日：1980-05-08

申请人： Kozo Kurihara ,  Toshio Fukazawa ,  Izuo Ichikawa ,  Yoshihiko Ikegami ,  Naohiko Fukiyama ,  Masaru Ikeda

发明人： Kozo Kurihara ,  Toshio Fukazawa ,  Izuo Ichikawa ,  Yoshihiko Ikegami ,  Naohiko Fukiyama ,  Masaru Ikeda

IPC分类号： A61K9/28 ,  A61K9/30 ,  A61K9/36 ,  A61K9/42 ,  C08L1/28

CPC分类号： A61K9/2826 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2866

摘要： Protective coating composition which comprises dispersed fine particles of one or more of compounds selected from a metal salt of a higher fatty acid, a higher fatty acid having a melting point of 40.degree.-90.degree. C., and a wax having a melting point of 40.degree.-90.degree. C. in an aqueous solution of a water-soluble film base and a surface-active agent having an HLB value of about 1.7 to 8.6 or silicon oil.

摘要翻译： 保护涂料组合物，其包含分散的一种或多种选自高级脂肪酸的金属盐，熔点为40〜90℃的高级脂肪酸和熔点为 40℃-90℃，水溶性薄膜基材和HLB值约为1.7至8.6的表面活性剂水溶液或硅油。

公开(公告)号：US5153003A

公开(公告)日：1992-10-06

申请号：US425367

申请日：1989-10-18

申请人： Kozo Kurihara ,  Hironobu Saito ,  Yukie Misho ,  Takeshi Oshima

发明人： Kozo Kurihara ,  Hironobu Saito ,  Yukie Misho ,  Takeshi Oshima

IPC分类号： A61L33/00

CPC分类号： A61L33/0041 ,  Y10S514/822 ,  Y10S514/953

摘要： A composition comprising a polymer having dispersed therethrough a prostacyclin derivative selected from the group consisting of compounds of formula (I): ##STR1## (in which R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents a C.sub.3 -C.sub.12 alkyl group or a C.sub.3 -C.sub.12 alkenyl group; and n is an integer from 1 to 5; and pharmaceutically acceptable salts thereof) can be used to make a medical appliance from which the prostaglandin, having antithrombotic properties, will be released gradually and in a controlled way.

公开(公告)号：US4990337A

公开(公告)日：1991-02-05

申请号：US511992

申请日：1990-04-12

申请人： Kozo Kurihara ,  Masaru Murano

发明人： Kozo Kurihara ,  Masaru Murano

IPC分类号： A61K9/107 ,  A61K38/13 ,  A61K47/14

CPC分类号： A61K47/14 ,  A61K38/13 ,  A61K9/1075 ,  Y10S514/885 ,  Y10S514/914

摘要： Cyclosporins are useful immunosuppressive, anti-fungal and antiphlogistic agents which are relatively insoluble in water and aqueous fluids (including body fluids). They may be rendered more soluble or dispersible in aqueous media by first dissolving them in at least one mono- or di- glyceride of a C.sub.6 -C.sub.10 fatty acid, and the resulting solution can then easily be emulsified in water or an aqueous fluid.

公开(公告)号：US4661162A

公开(公告)日：1987-04-28

申请号：US600308

申请日：1984-04-13

申请人： Kozo Kurihara ,  Yuji Otsuka ,  Toshio Fukazawa

发明人： Kozo Kurihara ,  Yuji Otsuka ,  Toshio Fukazawa

IPC分类号： A61K9/36 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/62 ,  A61K47/30 ,  C08L1/28

CPC分类号： A61K9/2866 ,  A61K9/286

摘要： An enteric-soluble composition for coating drugs and the like comprises a conventional enteric-soluble polymer in admixture with a polyanionic polymer which is soluble at low pH values. By altering proportions and types of both polymer, it is possible to alter the pH value at which the composition will disintegrate to release the drug or the like.

摘要翻译： 用于包衣药物等的肠溶性组合物包含与聚阴离子聚合物混合的常规肠溶可溶性聚合物，其在低pH值下是可溶的。 通过改变聚合物的比例和类型，可以改变组合物将分解以释放药物等的pH值。

公开(公告)号：US5051402A

公开(公告)日：1991-09-24

申请号：US587580

申请日：1990-09-21

申请人： Kozo Kurihara ,  Masaru Murano

发明人： Kozo Kurihara ,  Masaru Murano

IPC分类号： A61K38/00 ,  A61K9/08 ,  A61K9/18 ,  A61K38/13 ,  A61K47/00 ,  A61K47/40 ,  A61K47/48 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06

CPC分类号： B82Y5/00 ,  A61K38/13 ,  A61K47/48969 ,  Y10S514/885

摘要： Cyclosporins are useful immunosuppressive, anti-fungal and antiphlogistic agents which are relatively insoluble in water and aqueous fluids (including body fluids). They may be rendered more soluble by the concomitant administration of .alpha.-cyclodextrin, either separately, but essentially simultaneously or, preferably, in admixture.

公开(公告)号：US4497847A

公开(公告)日：1985-02-05

申请号：US540718

申请日：1983-10-11

申请人： Kozo Kurihara ,  Izuo Ichikawa ,  Hisanori Nakane ,  Yoshihiko Ikegami

发明人： Kozo Kurihara ,  Izuo Ichikawa ,  Hisanori Nakane ,  Yoshihiko Ikegami

IPC分类号： A61K47/38 ,  A61K9/28 ,  A61K9/30 ,  A61K9/36 ,  A61K9/42 ,  A61K9/54 ,  A61K9/56 ,  A61K47/30 ,  A61K9/38

CPC分类号： A61K9/2866 ,  A61K9/282 ,  A61K9/2826

摘要： A plasticizer for film-forming enteric polymers to be used in coating solid pharmaceutical preparations comprises a monoester or diester or both of glycerol with a saturated aliphatic carboxylic acid having from 6 to 10 carbon atoms. This is particularly useful for coating preparations from aqueous suspensions.

摘要翻译： 用于涂覆固体药物制剂的成膜肠溶性聚合物的增塑剂包括单酯或二酯或甘油与具有6至10个碳原子的饱和脂族羧酸两者。 这对于从水性悬浮液中涂覆制剂是特别有用的。