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    BIOMARKERS FOR THE PREDICTION OF RESPONSIVENESS TO CLOZAPINE TREATMENT
    1.
    发明申请
    BIOMARKERS FOR THE PREDICTION OF RESPONSIVENESS TO CLOZAPINE TREATMENT 审中-公开
    生物标志物预测对CLOZAPINE治疗的反应

    公开(公告)号：US20090281090A1

    公开(公告)日：2009-11-12

    申请号：US11571001

    申请日：2005-06-03

    申请人： Yunsheng He ,  Elisabeth Marie Leroy

    发明人： Yunsheng He ,  Elisabeth Marie Leroy

    IPC分类号： A61K31/5513 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  A61K31/5513 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： This invention provides methods to predict the likelihood of suicidal or self-destructive behaviour in a patient during treatment. The method employs the detection of a VNTR polymorphism in the 3′-UTR of the dopamine transporter gene (SLC6A3). Patients with nine or fewer repeats are considered poor responders to clozapine. Nine or fewer repeats in the SLC6A3 gene have been correlated with poor expression of the SLC6A3 gene. Also provided are methods of treatment based on the presence or absence of this polymorphism or surrogate markers thereof. Also provided are kits to use in the methods of the invention.

    摘要翻译： 本发明提供了预测治疗期间患者自杀或自毁行为的可能性的方法。 该方法采用多巴胺转运蛋白基因（SLC6A3）3'-UTR中VNTR多态性的检测方法。 9名或更少重复的患者被认为是氯氮平的不良反应者。 SLC6A3基因中9个重复序列与SLC6A3基因表达差异较大。 还提供了基于该多态性的存在或不存在或其替代标记的治疗方法。 还提供了用于本发明方法的试剂盒。

    BioMarkers for the Progression of Alzheimer's Disease
    5.
    发明申请
    BioMarkers for the Progression of Alzheimer's Disease 审中-公开
    阿尔茨海默病进展的生物标志物

    公开(公告)号：US20100035251A1

    公开(公告)日：2010-02-11

    申请号：US12305053

    申请日：2007-06-18

    申请人： Yunsheng He ,  Baltazar Gomez-Mancilla ,  Joanne Meyer ,  Giorgio Rovelli ,  Graeme Bilbe

    发明人： Yunsheng He ,  Baltazar Gomez-Mancilla ,  Joanne Meyer ,  Giorgio Rovelli ,  Graeme Bilbe

    IPC分类号： C12Q1/68 ,  C07D209/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC genotype tending to progress to Alzheimer's disease. Similar to the APOE-E4 allele, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showed a greater association with the rate of conversion from mild cognitive impairment to Alzheimer's disease. In another study with placebo-treated Alzheimer's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of association. The Alzheimer's disease patients with TT genotype of LRRK2-T1602S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive performance over 6 months, especially in the presence of a BuChE-K variant. The association between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathogenesis, especially disease progression, and that polymorphisms of LRRK2 can be used as biomrkers of this progression.

    摘要翻译： 遗传多态性LRRK2（富含亮氨酸的重复激酶2）-T1602S与轻度认知障碍（MCI）与阿尔茨海默病（AD）的转化显着相关，TT基因型患者进入阿尔茨海默氏病的风险更大。 LRRK2-T2352也显示出转变为阿尔茨海默病的趋势，CC基因型患者往往进展为阿尔茨海默氏病。 与APOE-E4等位基因相似，在BuChE-K变体存在下，LRRK2-T1602S和LRRK2-T2352显示与从轻度认知障碍转变为阿尔茨海默氏病的速率更大的关联。 在安慰剂治疗的阿尔茨海默病患者的另一项研究中，LRRK2-T1602S和LRRK2-T2352显示出相同的关联趋势。 具有LRRK2-T1602S的TT基因型或LRRK2-T2352的CC基因型的阿尔茨海默氏病患者在6个月以上的认知功能上往往更快下降，特别是在存在BuChE-K变体的情况下。 两种常见的LRRK2多态性与阿尔茨海默病进展的关系表明，LRRK2可能在阿尔茨海默氏病发病机制中发挥重要作用，特别是疾病进展，LRRK2的多态性可作为这一进展的生物学家。

    Fault tolerance in a parallel database system
    6.
    发明授权
    Fault tolerance in a parallel database system 有权
    并行数据库系统中的容错

    公开(公告)号：US08984328B2

    公开(公告)日：2015-03-17

    申请号：US13046414

    申请日：2011-03-11

    申请人： German A. Gil ,  Yunsheng He ,  Dale S. Grinnell ,  Paul Herman Dyke ,  Subhankar Aich ,  Ruwen Henning Hess

    发明人： German A. Gil ,  Yunsheng He ,  Dale S. Grinnell ,  Paul Herman Dyke ,  Subhankar Aich ,  Ruwen Henning Hess

    IPC分类号： G06F11/00 ,  G06F11/20

    CPC分类号： G06F11/2025 ,  G06F11/2028 ,  G06F11/2038 ,  G06F11/2043 ,  G06F2201/80

    摘要： Embodiments are directed to establishing a fault tolerant parallel database system and to detecting the health of parallel database services. In an embodiment, a computer system establishes a control node cluster that includes at least one active control node and at least one spare control node. Each node of the control node cluster includes specific functions assumable only by other control nodes. The computer system also establishes a compute node cluster that includes at least one active computing node, at least one spare computing node, at least one active storage node and at least one spare storage node. Each of the computing and storage nodes includes specific functions assumable only by other computing and storage nodes. The computer system detects a failure of an active node and instantiates a corresponding spare node that is configured to perform the functions of the failed active node.

    摘要翻译： 实施例涉及建立容错并行数据库系统并检测并行数据库服务的健康状况。 在一个实施例中，计算机系统建立包括至少一个主动控制节点和至少一个备用控制节点的控制节点集群。 控制节点集群的每个节点都包含仅由其他控制节点假定的特定功能。 计算机系统还建立包括至少一个活动计算节点，至少一个备用计算节点，至少一个活动存储节点和至少一个备用存储节点的计算节点集群。 每个计算和存储节点包括仅由其他计算和存储节点假定的特定功能。 计算机系统检测到活动节点的故障，并实例化配置为执行故障主动节点的功能的相应备用节点。

    FAULT TOLERANCE IN A PARALLEL DATABASE SYSTEM
    7.
    发明申请
    FAULT TOLERANCE IN A PARALLEL DATABASE SYSTEM 有权
    并行数据库系统中的容错

    公开(公告)号：US20120233496A1

    公开(公告)日：2012-09-13

    申请号：US13046414

    申请日：2011-03-11

    申请人： German A. Gil ,  Yunsheng He ,  Dale S. Grinnell ,  Paul Herman Dyke ,  Subhankar Aich ,  Ruwen Henning Hess

    发明人： German A. Gil ,  Yunsheng He ,  Dale S. Grinnell ,  Paul Herman Dyke ,  Subhankar Aich ,  Ruwen Henning Hess

    IPC分类号： G06F11/16

    CPC分类号： G06F11/2025 ,  G06F11/2028 ,  G06F11/2038 ,  G06F11/2043 ,  G06F2201/80

    摘要： Embodiments are directed to establishing a fault tolerant parallel database system and to detecting the health of parallel database services. In an embodiment, a computer system establishes a control node cluster that includes at least one active control node and at least one spare control node. Each node of the control node cluster includes specific functions assumable only by other control nodes. The computer system also establishes a compute node cluster that includes at least one active computing node, at least one spare computing node, at least one active storage node and at least one spare storage node. Each of the computing and storage nodes includes specific functions assumable only by other computing and storage nodes. The computer system detects a failure of an active node and instantiates a corresponding spare node that is configured to perform the functions of the failed active node.

    摘要翻译： 实施例涉及建立容错并行数据库系统并检测并行数据库服务的健康状况。 在一个实施例中，计算机系统建立包括至少一个主动控制节点和至少一个备用控制节点的控制节点集群。 控制节点集群的每个节点都包含仅由其他控制节点假定的特定功能。 计算机系统还建立包括至少一个活动计算节点，至少一个备用计算节点，至少一个活动存储节点和至少一个备用存储节点的计算节点集群。 每个计算和存储节点包括仅由其他计算和存储节点假定的特定功能。 计算机系统检测到活动节点的故障，并实例化配置为执行故障主动节点的功能的相应备用节点。