公开(公告)号：US4880736A

公开(公告)日：1989-11-14

申请号：US788812

申请日：1985-10-18

申请人： Yutaka Tsunemi ,  Satoru Asahi ,  Muneharu Doi

发明人： Yutaka Tsunemi ,  Satoru Asahi ,  Muneharu Doi

IPC分类号： C12P19/38 ,  C12R1/07 ,  C12R1/10 ,  C12R1/125

CPC分类号： C12P19/385 ,  Y10S435/832 ,  Y10S435/836 ,  Y10S435/839

摘要： Uridine is produced by cultivating in a culture medium a uridine-producing microorganism, which belongs to the genus Bacillus and which is deficient in uridine nucleoside phosphorylase activity and is resistant to a pyrimidine analogue, and recovering the accumulated uridine. This method has the advantage of substantially avoiding the by-production of uracil and uridylic acid.

摘要翻译： 通过在培养基中培养属于芽孢杆菌属的尿苷核苷磷酸化酶活性并且对嘧啶类似物具有抗性并且回收积累的尿苷的尿苷生产微生物产生尿苷酸。 该方法具有基本避免副产尿嘧啶和尿苷酸的优点。

公开(公告)号：US4839285A

公开(公告)日：1989-06-13

申请号：US802344

申请日：1985-11-25

申请人： Satoru Asahi ,  Yutaka Tsunemi ,  Muneharu Doi

发明人： Satoru Asahi ,  Yutaka Tsunemi ,  Muneharu Doi

IPC分类号： C12N1/20 ,  C12P19/38 ,  C12R1/125

CPC分类号： C12P19/385 ,  Y10S435/839

摘要： Cytidine and/or deoxycytidine are produced at high yields by culturing cytidine deaminase activity-defective microbes of the genus Bacillus, which have resistance to pyrimidine analogs and with the ability to produce cytidine and/or deoxycytidine in a medium.

摘要翻译： 通过培养具有对嘧啶类似物的抗性并具有在培养基中产生胞苷和/或脱氧胞苷的能力的芽孢杆菌属的胞苷脱氨酶活性缺陷型微生物，以高产率产生胞苷和/或脱氧胞苷。