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1.发明申请公开(公告)号：US20100240584A1
公开(公告)日：2010-09-23
申请号：US12290059
申请日：2008-10-27
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA, expression systems.
摘要翻译： 具有作为抗凝剂和/或丝氨酸蛋白酶抑制剂的活性并具有至少一个NAP结构域并被描述的蛋白质。 这些蛋白质中的某些具有因子Xa抑制活性，而其他蛋白质具有作为因子VIIa / TF的抑制剂的活性。 这些蛋白质可以从天然来源分离为线虫，化学合成或通过使用各种DNA，表达系统的重组方法制备。
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2.发明授权公开(公告)号：US06534629B1
公开(公告)日：2003-03-18
申请号：US09249473
申请日：1999-02-12
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C07K100
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
摘要翻译： 具有作为抗凝剂和/或丝氨酸蛋白酶抑制剂的活性并具有至少一个NAP结构域并被描述的蛋白质。 这些蛋白质中的某些具有因子Xa抑制活性，而其他蛋白质具有作为因子VIIa / TF的抑制剂的活性。 这些蛋白质可以从天然来源分离为线虫，化学合成或通过使用各种DNA表达系统的重组方法制备。
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公开(公告)号：US6087487A
公开(公告)日：2000-07-11
申请号：US249451
申请日：1999-02-12
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C12N15/09 , A61K35/56 , A61K38/00 , A61P7/02 , C07K14/81 , C12N9/99 , C12N15/12 , C12N15/19 , C07H21/04
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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公开(公告)号：US06046318A
公开(公告)日：2000-04-04
申请号：US249472
申请日：1999-02-12
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C12N15/09 , A61K35/56 , A61K38/00 , A61P7/02 , C07K14/81 , C12N9/99 , C12N15/12 , C12N15/19 , C07H20/04
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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公开(公告)号：US5945275A
公开(公告)日：1999-08-31
申请号：US326110
申请日：1994-10-18
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
摘要翻译： 蛋白质是有效的抗凝剂并具有至少一个NAP结构域并被描述。 具有抗凝活性的这些蛋白质可以从天然来源分离为线虫，化学合成或通过使用各种DNA表达系统的重组方法制备。
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公开(公告)号：US6121435A
公开(公告)日：2000-09-19
申请号：US249448
申请日：1999-02-12
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C12N15/09 , A61K35/56 , A61K38/00 , A61P7/02 , C07K14/81 , C12N9/99 , C12N15/12 , C12N15/19 , C07H21/04
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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7.发明授权
公开(公告)号：US6090916A
公开(公告)日：2000-07-18
申请号：US809455
申请日：1997-11-24
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C12N15/09 , A61K35/56 , A61K38/00 , A61P7/02 , C07K14/81 , C12N9/99 , C12N15/12 , C12N15/19 , C07K1/00
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
摘要翻译： PCT No.PCT / US95 / 13231 Sec。 371日期：1997年11月24日 102（e）1997年11月24日PCT PCT 1995年10月17日PCT公布。 公开号WO96 / 12021 日期1996年04月25日具有作为抗凝剂和/或丝氨酸蛋白酶抑制剂的活性并具有至少一个NAP结构域并被描述的蛋白质。 这些蛋白质中的某些具有因子Xa抑制活性，而其他蛋白质具有作为因子VIIa / TF的抑制剂的活性。 这些蛋白质可以从天然来源分离为线虫，化学合成或通过使用各种DNA表达系统的重组方法制备。
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公开(公告)号：US6040441A
公开(公告)日：2000-03-21
申请号：US249471
申请日：1999-02-12
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C12N15/09 , A61K35/56 , A61K38/00 , A61P7/02 , C07K14/81 , C12N9/99 , C12N15/12 , C12N15/19 , C07H21/04
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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公开(公告)号：US5866543A
公开(公告)日：1999-02-02
申请号：US486399
申请日：1995-06-05
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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公开(公告)号：US06872808B1
公开(公告)日：2005-03-29
申请号：US09498556
申请日：2000-02-04
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Josef Lauwereys , Yves Rene LaRoche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
IPC分类号： C12N15/09 , A61K35/56 , A61K38/00 , A61P7/02 , C07K14/81 , C12N9/99 , C12N15/12 , C12N15/19 , A61K35/14 , C07K14/00 , C07K38/00
CPC分类号： A61K38/55 , C07K14/811 , C12P21/02 , Y10S530/829
摘要： Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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