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公开(公告)号：US20090042802A1
公开(公告)日：2009-02-12
申请号：US12143684
申请日：2008-06-20
Applicant: YIJUN PAN , Christopher Holmes , Yvonne Angell
Inventor： YIJUN PAN , Christopher Holmes , Yvonne Angell
CPC classification number: C07K14/50 , A61K38/00 , C07K2319/74
Abstract: The present invention relates to peptide compounds that bind the KGF receptor. The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with defective or insufficient epithelial cell proliferation. Pharmaceutical compositions, which comprise the peptide compounds of the invention, and dosages are also provided.
Abstract translation: 本发明涉及结合KGF受体的肽化合物。 本发明还涉及使用这些肽化合物治疗与有缺陷或不足的上皮细胞增殖相关的疾病的治疗方法。 还提供了包含本发明的肽化合物的药物组合物和剂量。
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公开(公告)号：US20070203066A1
公开(公告)日：2007-08-30
申请号：US11636353
申请日：2006-12-08
Applicant: Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
Inventor： Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
CPC classification number: A61K38/08 , A61K38/10 , A61K47/55 , A61K47/60 , A61K47/62 , C07K7/08 , C07K14/001
Abstract: Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.
Abstract translation: 提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。 组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。 所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。 该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。 将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。
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公开(公告)号：US20080090760A2
公开(公告)日：2008-04-17
申请号：US11636353
申请日：2006-12-08
Applicant: Todd Hembrough , Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
Inventor： Todd Hembrough , Christopher Holmes , Qun Yin , Genet Zemede , Yvonne Angell , Brian Frederick , Caiding Xu
CPC classification number: A61K38/08 , A61K38/10 , A61K47/55 , A61K47/60 , A61K47/62 , C07K7/08 , C07K14/001
Abstract: Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.
Abstract translation: 提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。 组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。 所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。 该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。 将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。
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