公开(公告)号：US11844829B2

公开(公告)日：2023-12-19

申请号：US16474940

申请日：2017-12-21

申请人： ZalVac AB

发明人： Birgitta Henriques Normark ,  Mario Codemo ,  Federico Iovino ,  Sandra Muschiol ,  Staffan Normark ,  Sun Nyunt Wai

IPC分类号： A61K39/09 ,  C07K14/315 ,  A61K39/00 ,  C07K16/12

CPC分类号： A61K39/092 ,  C07K14/3156 ,  C07K16/1275 ,  A61K2039/55555

摘要： An isolated Streptococcus pneumoniae membrane vesicle microparticle (MP), wherein said MP comprises: the protein Ply at the level of ≥0.070 μg/μg total protein in the MP; and/or the protein LytA at the level of ≥0.070 μg/μg total protein in the MP; and/or the protein PspC at the level of ≥0.130 μg/μg total protein in the MP; and/or the protein RrgB at the level of ≥0.020 μg/μg total protein in the MP. Compositions comprising such MPs. Uses thereof in particular in immunization, as well as methods of manufacture thereof.

公开(公告)号：US20230330203A1

公开(公告)日：2023-10-19

申请号：US18212857

申请日：2023-06-22

申请人： ZalVac AB

发明人： Birgitta Henriques Normark ,  Mario Codemo ,  Federico Iovino ,  Sandra Muschiol ,  Staffan Normark ,  Sun Nyunt Wai

IPC分类号： A61K39/09 ,  C07K14/315 ,  C07K16/12

CPC分类号： A61K39/092 ,  C07K14/3156 ,  C07K16/1275 ,  A61K2039/55555

摘要： An isolated Streptococcus pneumoniae membrane vesicle microparticle (MP), wherein said MP comprises: the protein Ply at the level of ≥0.070 μg/μg total protein in the MP; and/or the protein LytA at the level of ≥0.070 μg/μg total protein in the MP; and/or the protein PspC at the level of ≥0.130 μg/μg total protein in the MP; and/or the protein RrgB at the level of ≥0.020 μg/μg total protein in the MP. Compositions comprising such MPs. Uses thereof in particular in immunization, as well as methods of manufacture thereof.

公开(公告)号：US20230365647A1

公开(公告)日：2023-11-16

申请号：US18013679

申请日：2021-06-29

申请人： ZALVAC AB

发明人： Birgitta HENRIQUES NORMARK ,  Karthik SUBRAMANIAM ,  Georgios SOTIRIOU

IPC分类号： C07K14/705 ,  A61P31/04 ,  A61K9/00

CPC分类号： C07K14/705 ,  A61P31/04 ,  A61K9/0043

摘要： A polypeptide or peptidomimetic comprising a sequence of at least 7 residues differing by residue substitutions, deletions or insertions numbering 0-2 compared to the sequence: GLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPT-MSWNDINCEHLNNWICQ (SEQ ID NO: 1), for use as a medicament, in particular in pneumococcal disease.

公开(公告)号：US20230270835A1

公开(公告)日：2023-08-31

申请号：US18016298

申请日：2021-07-12

申请人： ZALVAC AB

发明人： Birgitta HENRIQUES NORMARK ,  Staffan Normark ,  Federico Iovino ,  Ana Rita Narciso ,  Peter Mellroth

IPC分类号： A61K39/09 ,  C12N15/74 ,  A61P31/04

CPC分类号： A61K39/092 ,  C12N15/746 ,  A61P31/04 ,  A61K2039/55555

摘要： An immunogenic composition comprising bacterial membrane vesicles (MVs) comprising a streptococcal MalX antigen and/or a streptococcal PrsA antigen, characterized in that the MVs do not comprise an immunogenic amount of a streptococcal PspA antigen. The membrane vesicles may be artificial membrane particles. Medical uses of the composition in particular for immunization against pneumococcal disease, and methods of manufacturing the composition.