公开(公告)号：US20110160518A1

公开(公告)日：2011-06-30

申请号：US13010366

申请日：2011-01-20

Applicant: Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

Inventor： Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

IPC: A61M1/10

CPC classification number: A61M1/3653 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/3656 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/04 ,  A61M2025/0004 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2205/3334 ,  A61M2210/125

Abstract: A system for assisting flow of blood by a patient's heart. The system includes a transseptal cannula adapted to be inserted percutaneously in the vascular system and extend through the atrial septum from the right atrium to the left atrium. The system includes a blood pump mechanism having a blood pump for pumping blood received from the transseptal cannula that has been oxygenated at specified flow rates over a range of physiological pressures. The blood pump is connected to the transseptal cannula. The system includes a perfusion cannula adapted to be inserted percutaneously in the vascular system for returning oxygenated blood to the atrial system of the patient. The perfusion cannula is connected to the blood pump.

Abstract translation: 一种辅助患者心脏血液流动的系统。 该系统包括适于经皮插入血管系统并经由心房隔膜从右心房延伸到左心房的经血管插管。 该系统包括血泵机构，该血泵机构具有血泵，用于泵送经由经套管插管的血液，所述经血管插管已经在特定流速下在一定范围的生理压力下被氧化。 血泵连接到经血管插管。 该系统包括适于经皮插入血管系统中以将含氧血液返回到患者心房系统的灌注插管。 灌注套管连接到血液泵。

公开(公告)号：US08454549B2

公开(公告)日：2013-06-04

申请号：US13010366

申请日：2011-01-20

Applicant: Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

Inventor： Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

IPC: A61M37/00 ,  A61N1/362

CPC classification number: A61M1/3653 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/3656 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/04 ,  A61M2025/0004 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2205/3334 ,  A61M2210/125

Abstract: A pumping system for assisting a patient's heart includes a blood pump disposed outside the patient's body and having an inlet and an outlet. An inlet cannula is configured for insertion percutaneously into the vascular system of the patient, and in fluid communication with the blood pump inlet to provide blood to the blood pump. An outlet perfusion cannula is configured for insertion percutaneously into the vascular system of the patient, and in fluid communication with the blood pump outlet to provide blood to the patient's vascular system. A control system is provided to control the blood pump and includes at least two control units for redundant control of the blood pump. Each control unit includes a watchdog for monitoring the control unit. A variation of the pumping system includes a bidirectional cannula for insertion percutaneously into the vascular system of the patient and to extend into the patient's heart.

Abstract translation: 用于辅助患者心脏的抽吸系统包括设置在患者身体外部并具有入口和出口的血泵。 入口插管构造成经皮插入患者的血管系统中，并与血泵入口流体连通以向血液泵提供血液。 出血灌注插管经配置以经皮插入患者的血管系统中，并与血泵出口流体连通以向患者的血管系统提供血液。 提供控制系统以控制血液泵并且包括用于血液泵的冗余控制的至少两个控制单元。 每个控制单元包括用于监视控制单元的看门狗。 泵送系统的变体包括用于经皮插入患者的血管系统并延伸到患者心脏中的双向插管。

公开(公告)号：US08622949B2

公开(公告)日：2014-01-07

申请号：US13082487

申请日：2011-04-08

Applicant: Zafiris G. Zafirelis ,  Yih-Choung Yu ,  John C. Marous, III ,  Kirk A. Lehmann ,  Gregory A. Johnson

Inventor： Zafiris G. Zafirelis ,  Yih-Choung Yu ,  John C. Marous, III ,  Kirk A. Lehmann ,  Gregory A. Johnson

IPC: A61M37/00 ,  A61N1/362

CPC classification number: A61M1/3653 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/3656 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/04 ,  A61M2025/0004 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2205/3334 ,  A61M2210/125

Abstract: A method of providing a pumping system for assisting a human patient's heart and providing a blood pump to be disposed outside the patient's body is disclosed. The blood pump has an inlet and an outlet. An inlet cannula is provided for insertion percutaneously into the vascular system of the patient, and is adapted to be placed in fluid communication with the blood pump inlet to provide blood to the blood pump. An outlet perfusion cannula is provided for insertion percutaneously into the vascular system of the patient, and is adapted to be placed in fluid communication with the blood pump outlet to provide blood to the patient's vascular system. The blood pump includes a control system to control the blood pump. The control system includes at least two control units for redundant control of the blood pump, and each control unit includes a watchdog for monitoring the control unit.

Abstract translation: 公开了一种提供用于辅助人类患者心脏并提供将血液泵放置在患者身体外部的泵送系统的方法。 血泵有一个入口和一个出口。 提供入口套管用于经皮插入到患者的血管系统中，并适于与血泵入口流体连通以向血液泵提供血液。 提供出血灌注插管，用于经皮插入到患者的血管系统中，并适于与血泵出口流体连通以向患者的血管系统提供血液。 血泵包括控制血液泵的控制系统。 所述控制系统包括用于所述血液泵的冗余控制的至少两个控制单元，并且每个控制单元包括用于监视所述控制单元的看门狗。

公开(公告)号：US20110245582A1

公开(公告)日：2011-10-06

申请号：US13082487

申请日：2011-04-08

Applicant: Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

Inventor： Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

IPC: A61M1/10

CPC classification number: A61M1/3653 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/3656 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/04 ,  A61M2025/0004 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2205/3334 ,  A61M2210/125

Abstract: A method of providing a pumping system for assisting a human patient's heart and providing a blood pump to be disposed outside the patient's body is disclosed. The blood pump has an inlet and an outlet. An inlet cannula is provided for insertion percutaneously into the vascular system of the patient, and is adapted to be placed in fluid communication with the blood pump inlet to provide blood to the blood pump. An outlet perfusion cannula is provided for insertion percutaneously into the vascular system of the patient, and is adapted to be placed in fluid communication with the blood pump outlet to provide blood to the patient's vascular system. The blood pump includes a control system to control the blood pump. The control system includes at least two control units for redundant control of the blood pump, and each control unit includes a watchdog for monitoring the control unit.

Abstract translation: 公开了一种提供用于辅助人类患者心脏并提供将血液泵放置在患者身体外部的泵送系统的方法。 血泵有一个入口和一个出口。 提供入口套管用于经皮插入到患者的血管系统中，并适于与血泵入口流体连通以向血液泵提供血液。 提供出血灌注插管，用于经皮插入患者的血管系统中，并适于与血泵出口流体连通，以向患者的血管系统提供血液。 血泵包括控制血液泵的控制系统。 所述控制系统包括用于所述血液泵的冗余控制的至少两个控制单元，并且每个控制单元包括用于监视所述控制单元的看门狗。

公开(公告)号：US07896832B2

公开(公告)日：2011-03-01

申请号：US10969688

申请日：2004-10-20

Applicant: Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

Inventor： Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Greg A. Johnson

IPC: A61M37/00 ,  A61N1/362

CPC classification number: A61M1/3653 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/3656 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/04 ,  A61M2025/0004 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2205/3334 ,  A61M2210/125

Abstract: A system for assisting flow of blood by a patient's heart. The system includes a transseptal cannula adapted to be inserted percutaneously in the jugular vein and extend through the atrial septum from the right atrium to the left atrium. The system includes a blood pump mechanism having a blood pump for pumping blood received from the transseptal cannula that has been oxygenated at specified flow rates over a range of physiological pressures. The blood pump is connected to the transseptal cannula. The system includes a perfusion cannula adapted to be inserted percutaneously in the axillary artery for returning oxygenated blood to the atrial system of the patient. The perfusion cannula is connected to the blood pump. A method for assisting blood flow by a patient's heart. The method includes the steps of inserting percutaneously in the jugular vein of the patient and extending through the atrial septum from the right atrium to the left atrium a transseptal cannula. Next there is the step of inserting percutaneously in the axillary artery a perfusion cannula for returning oxygenated blood to the arterial system of the patient. Then there is the step of pumping blood with a blood pump connected to the transseptal cannula and the perfusion cannula at specified flow rates over a range of physiological pressures.

Abstract translation: 一种辅助患者心脏血液流动的系统。 该系统包括适于经皮插入颈静脉并经由心房隔膜从右心房延伸到左心房的经血管插管。 该系统包括血泵机构，该血泵机构具有血泵，用于泵送经由经套管插管的血液，所述经血管插管已经在特定流速下在一定范围的生理压力下被氧化。 血泵连接到经血管插管。 该系统包括适于经皮插入腋动脉以将氧合血液返回到患者心房系统的灌注插管。 灌注套管连接到血液泵。 一种辅助患者心脏血液流动的方法。 该方法包括以下步骤：将经皮插入患者的颈静脉并延伸通过心房隔膜从右心房延伸至左心房经胸插管。 接下来，存在在腋动脉中经皮插入用于将氧合血液返回到患者的动脉系统的灌注套管的步骤。 然后，在一定范围的生理压力下，以指定的流速连接到经血管插管和灌注插管的血泵抽血。

公开(公告)号：US06808508B1

公开(公告)日：2004-10-26

申请号：US09661413

申请日：2000-09-13

Applicant: Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Gregory A. Johnson

Inventor： Zafiris G. Zafirelis ,  John C. Marous, III ,  Yih-Choung Yu ,  Kirk A. Lehmann ,  Gregory A. Johnson

IPC: A61M3700

CPC classification number: A61M1/3653 ,  A61M1/10 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/3656 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/04 ,  A61M2025/0004 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0089 ,  A61M2205/3334 ,  A61M2210/125

Abstract: A system for assisting flow of blood by a patient's heart. The system includes a transseptal cannula adapted to be inserted percutaneously in the femoral vein and extend through the atrial septum from the right atrium to the left atrium. The system includes a blood pump mechanism having a blood pump for pumping blood received from the transseptal cannula that has been oxygenated at specified flow rates over a range of physiological pressures. The blood pump is connected to the transseptal cannula. The system includes a perfusion cannula adapted to be inserted percutaneously in the femoral artery for returning oxygenated blood to the atrial system of the patient. The perfusion cannula is connected to the blood pump. A method for assisting blood flow by a patient's heart. The method includes the steps of inserting percutaneously in the femoral vein of the patient and extending through the atrial septum from the right atrium to the left atrium a transseptal cannula. Next there is the step of inserting percutaneously in the femoral artery a perfusion cannula for returning oxygenated blood to the arterial system of the patient. Then there is the step of pumping blood with a blood pump connected to the transseptal cannula and the perfusion cannula at specified flow rates over a range of physiological pressures.

Abstract translation: 一种辅助患者心脏血液流动的系统。 该系统包括适于经皮插入股静脉并经由心房隔膜从右心房延伸到左心房的经外套管。 该系统包括血泵机构，该血泵机构具有血泵，用于泵送经由经套管插管的血液，所述经血管插管已经在特定流速下在一定范围的生理压力下被氧化。 血泵连接到经血管插管。 该系统包括适于经皮插入股动脉以将氧合血液返回到患者心房系统的灌注插管。 灌注套管连接到血液泵。 一种辅助患者心脏血液流动的方法。 该方法包括以下步骤：经皮插入患者的股静脉中，并延伸穿过房间隔从右心房向左心房延伸穿过套管。 接下来，存在在股动脉中经皮插入用于将氧合血液返回到患者的动脉系统的灌注套管的步骤。 然后，在一定范围的生理压力下，以指定的流速连接到经血管插管和灌注插管的血泵抽血。