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公开(公告)号：US20080075734A1
公开(公告)日：2008-03-27
申请号：US11846977
申请日：2007-08-29
申请人： Zane Neal , Hans Herweijer
发明人： Zane Neal , Hans Herweijer
CPC分类号： A61K39/0011 , A61K38/18 , A61K38/193 , A61K38/208 , A61K48/0016 , A61K48/005 , A61K48/0075 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2300/00
摘要： Proper timing and combinatorial administration of immunocytokines and Flt3-L combined with vaccination with tumor associated antigens provides an anticancer therapeutic benefit. Sequential administration of GM-CSF after Flt3-L provides improved expansion of mature dendritic cell populations. The expansion of mature dendritic cells can be used to enhance an immune response in the subject.
摘要翻译： 联合免疫细胞因子和Flt3-L联合给予肿瘤相关抗原的合适时机和组合给药提供抗癌治疗益处。 Flt3-L后，GM-CSF的顺序给药提供了成熟树突状细胞群体的改良扩增。 成熟树突状细胞的扩增可用于增强受试者的免疫应答。
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公开(公告)号：US20050192242A1
公开(公告)日：2005-09-01
申请号：US11095793
申请日：2005-03-31
申请人： Zane Neal , Hans Herweijer , Jon Wolff
发明人： Zane Neal , Hans Herweijer , Jon Wolff
CPC分类号： C12N15/113 , A61K31/70 , A61K48/00 , A61K48/0008 , A61K48/0075 , A61K48/0083 , C07H21/00 , C12N15/87 , C12N2320/32 , A61K2300/00
摘要： Chimeric antitumor compounds for the treatment of cancer are disclosed. The chimeric compounds may be encoded by a nucleic acid. Delivery of the nucleic acid to cells in vivo provides for in vivo production of the antitumor compounds.
摘要翻译： 公开了用于治疗癌症的嵌合抗肿瘤化合物。 嵌合化合物可以由核酸编码。 核酸在体内递送到细胞中提供抗体化合物的体内产生。
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公开(公告)号：US6044932A
公开(公告)日：2000-04-04
申请号：US332748
申请日：1999-06-14
CPC分类号： B65G1/07
摘要： A device for and method of ergonomically removing parts from a parts bin, so that an operator does not have to unnecessarily bend to remove parts, using an open-ended bin, a platform removably contained within the bin, and a mechanism for lifting the platform which is, also, removably contained within the bin. The mechanism for lifting the platform may be a manually operated or automatically operated scissor-type jack, hydraulic cylinder, or pneumatic cylinder. Also, the platform may be vertically adjusted by a spring whose spring constant is chosen to correspond to the weight of the parts within the bin.
摘要翻译： 一种用于人体工程学地从零件箱移除零件的装置和方法，使得操作者不必不必要地弯曲以使用开放式仓，可拆卸地容纳在仓内的平台以及用于提升平台的机构 这也是可拆卸地包含在箱内。 用于提升平台的机构可以是手动操作或自动操作的剪刀式千斤顶，液压缸或气动缸。 此外，平台可以通过弹簧垂直地调节，弹簧的弹簧常数被选择成对应于料仓内部件的重量。
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公开(公告)号：US20050054612A1
公开(公告)日：2005-03-10
申请号：US10929697
申请日：2004-08-30
申请人： Sean Monahan , Vladimir Budker , Zane Neal , Vladimir Subbotin
发明人： Sean Monahan , Vladimir Budker , Zane Neal , Vladimir Subbotin
CPC分类号： C07F7/10 , A61K9/0019 , A61K31/58 , A61K31/695 , A61K47/54 , C07J1/00
摘要： Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytic ally labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells is described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
摘要翻译： 描述了增加药物对细胞的区域递送的药物制剂。 描述了通过疏水部分的水解不亲和性附着可逆地增加药物的疏水性的方法和将修饰的药物递送至细胞的方法。 疏水性修饰增加药物递送，同时使药物最小化进入非靶细胞。
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公开(公告)号：US20070048254A1
公开(公告)日：2007-03-01
申请号：US11467033
申请日：2006-08-24
申请人： Zane Neal , Hans Herweijer
发明人： Zane Neal , Hans Herweijer
CPC分类号： A61K39/39 , A61K38/177 , A61K38/18 , A61K38/193 , A61K2039/545 , A61K2039/55522 , A61K2300/00
摘要： A method is provided for expanding the population of mature dendritic cells in an individual subject. Proper timing of sequential delivery of Flt3-L and GM-CSF provides improved expansion of mature dendritic cell populations over methods currently employed in the art. The expansion of mature dendritic cells can be used to enhance an immune response in the subject. The mature dendritic cells can also be isolated from the subject for use in biological research.
摘要翻译： 提供了一种用于扩大个体受试者中成熟树突细胞群体的方法。 顺序递送Flt3-L和GM-CSF的适当时机提高了成熟树突状细胞群体与本领域目前使用的方法的扩增。 成熟树突状细胞的扩增可用于增强受试者的免疫应答。 成熟树突状细胞也可以从受试者中分离出来用于生物研究。
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公开(公告)号：US6035973A
公开(公告)日：2000-03-14
申请号：US843802
申请日：1997-04-21
CPC分类号： B65G1/07
摘要： A device for and method of ergonomically removing parts from a parts bin, so that an operator does not have to unnecessarily bend to remove parts, using an open-ended bin, a platform removably contained within the bin, and a mechanism for lifting the platform which is, also, removably contained within the bin. The mechanism for lifting the platform may be a manually operated or automatically operated scissor-type jack, hydraulic cylinder, or pneumatic cylinder. Also, the platform may be vertically adjusted by a spring whose spring constant is chosen to correspond to the weight of the parts within the bin.
摘要翻译： 一种用于人体工程学地从零件箱移除零件的装置和方法，使得操作者不必不必要地弯曲以使用开放式仓，可拆卸地容纳在仓内的平台以及用于提升平台的机构 这也是可拆卸地包含在箱内。 用于提升平台的机构可以是手动操作或自动操作的剪刀式千斤顶，液压缸或气动缸。 此外，平台可以通过弹簧垂直地调节，弹簧的弹簧常数被选择成对应于料仓内部件的重量。
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