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公开(公告)号：US20050054612A1
公开(公告)日：2005-03-10
申请号：US10929697
申请日：2004-08-30
申请人： Sean Monahan , Vladimir Budker , Zane Neal , Vladimir Subbotin
发明人： Sean Monahan , Vladimir Budker , Zane Neal , Vladimir Subbotin
CPC分类号： C07F7/10 , A61K9/0019 , A61K31/58 , A61K31/695 , A61K47/54 , C07J1/00
摘要： Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytic ally labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells is described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
摘要翻译： 描述了增加药物对细胞的区域递送的药物制剂。 描述了通过疏水部分的水解不亲和性附着可逆地增加药物的疏水性的方法和将修饰的药物递送至细胞的方法。 疏水性修饰增加药物递送，同时使药物最小化进入非靶细胞。
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公开(公告)号：US20060115462A1
公开(公告)日：2006-06-01
申请号：US11286719
申请日：2005-11-23
申请人： Vladimir Subbotin , Julia Hegge
发明人： Vladimir Subbotin , Julia Hegge
IPC分类号： A61K48/00
CPC分类号： A61K48/0083 , A61K38/1875 , A61K48/0075
摘要： An method is described that enables in vivo delivery of polynucleotides to cells of a mammalian bone limb. The method involves the injection of polynucleotides in a large volume into the lumen of the bone.
摘要翻译： 描述了能够将多核苷酸体内递送到哺乳动物骨肢的细胞的方法。 该方法包括将大量体内的多核苷酸注射到骨的内腔中。
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3.发明申请Reversible Hydrophobic Modification of Drugs for Improved Delivery to Cells 审中-公开用于改善细胞递送的药物的可逆疏水改性公开(公告)号：US20090074885A1
公开(公告)日：2009-03-19
申请号：US12260679
申请日：2008-10-29
IPC分类号： A61K31/704 , A61K33/24 , A61K31/337 , A61P35/04 , A61K31/195
CPC分类号： A61K31/58 , A61K9/0019 , A61K31/195 , A61K31/337 , A61K31/695 , A61K31/704 , A61K47/54 , A61K47/542 , C07F7/10 , C07F7/1804 , C07J1/00
摘要： Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytically labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells are described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
摘要翻译： 描述了增加药物对细胞的区域递送的药物制剂。 描述了通过疏水部分的水解不稳定连接可逆地增加药物的疏水性的方法和将修饰的药物递送至细胞的方法。 疏水性修饰增加药物递送，同时使药物最小化进入非靶细胞。
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4.发明授权Devices and processes for distribution of genetic material to mammalian limb 失效将遗传物质分配给哺乳动物肢体的装置和方法公开(公告)号：US07214369B2
公开(公告)日：2007-05-08
申请号：US10429478
申请日：2003-05-05
CPC分类号： A61K48/0075 , A61K38/1825 , A61K38/1866
摘要： A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.
摘要翻译： 描述了将治疗性多核苷酸递送至患有或可能患有缺血的肢体肌肉组织的方法。 将多核苷酸插入哺乳动物肢体血管如动脉。 通过将含有多核苷酸的溶液的注入与使用外部应用的袖带组合来提高递送效率和分布。
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公开(公告)号：US07589059B2
公开(公告)日：2009-09-15
申请号：US10628792
申请日：2003-07-28
申请人： Jon A. Wolff , Vladimir G. Budker , Hans Herweijer , James E. Hagstrom , Sean D. Monahan , Julia Hegge , Vladimir Subbotin
发明人： Jon A. Wolff , Vladimir G. Budker , Hans Herweijer , James E. Hagstrom , Sean D. Monahan , Julia Hegge , Vladimir Subbotin
CPC分类号： A61K9/0019 , A61K38/00 , A61K48/0075 , C12N15/87 , C12N2799/022
摘要： Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate transiently increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the molecule to the cell.
摘要翻译： 公开了一种使用血管内施用途径向血管外哺乳动物细胞体内递送分子或复合物的系统。 将分子或复合物插入哺乳动物脉管系统的注射溶液中。 以适当的速率插入注射溶液瞬时增加组织中血管外流体的体积，从而便于将分子递送至细胞。
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