公开(公告)号：US20110288167A1

公开(公告)日：2011-11-24

申请号：US13112180

申请日：2011-05-20

申请人： Chunshun Zhao ,  Zhanqi Niu ,  Zhen Chen ,  Haibo Guo

发明人： Chunshun Zhao ,  Zhanqi Niu ,  Zhen Chen ,  Haibo Guo

IPC分类号： A61K31/343

摘要： The present invention discloses a butylphthalide intravenous emulsion for intravenous injection or infusion, containing butylphthalide or derivatives thereof as an active ingredient in an amount of 0.01˜50 wt % and an excipient in an amount of 50˜99.99 wt %, based on the total weight of the emulsion.

摘要翻译： 本发明公开了一种用于静脉注射或输注的丁基苯酞地静滴乳剂，其含量为0.01〜50重量％的丁基苯酞或其衍生物作为活性成分，赋形剂的含量为总重量的50〜99.99重量％ 的乳液。

公开(公告)号：US20090281177A1

公开(公告)日：2009-11-12

申请号：US12086665

申请日：2006-12-15

申请人： Chunshun Zhao ,  Zhanqi Niu ,  Zhen Chen ,  Haibo Guo

发明人： Chunshun Zhao ,  Zhanqi Niu ,  Zhen Chen ,  Haibo Guo

IPC分类号： A61K31/343

CPC分类号： A61K9/107 ,  A61K9/0019 ,  A61K31/365

摘要： The present invention discloses a butylphthalide intravenous emulsion for intravenous injection or infusion, containing butylphthalide or derivatives thereof as an active ingredient in an amount of 0.01˜50 wt % and an excipient in an amount of 50˜99.99 wt %, based on the total weight of the emulsion.

摘要翻译： 本发明公开了一种用于静脉注射或输注的丁基苯酞地静滴乳剂，其含量为0.01〜50重量％的丁基苯酞或其衍生物作为活性成分，基于总重量为50〜99.99重量％的赋形剂 的乳液。

公开(公告)号：US09795585B2

公开(公告)日：2017-10-24

申请号：US11458650

申请日：2006-07-19

申请人： Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

发明人： Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

IPC分类号： A61K31/33 ,  A61K31/343

CPC分类号： A61K31/343

摘要： The inventive subject matter relates to the use of L-butylphthalide in the manufacturing of medicaments for the prevention and treatment of cerebral ischemia-induced disease. Cerebral ischemia of the animals or human induces cerebral infarction, neurological deficit, memory disorder, cerebral edema, cerebral apoplexy, metabolic disorder of energy, changes of cerebral blood flow, and the like. The in vivo experiments show that L-butylphthalide can effectively reduce the above-mentioned adverse symptoms induced by cerebral ischemia.

公开(公告)号：US10463614B2

公开(公告)日：2019-11-05

申请号：US13112180

申请日：2011-05-20

申请人： Chunshun Zhao ,  Zhanqi Niu ,  Zhen Chen ,  Haibo Guo

发明人： Chunshun Zhao ,  Zhanqi Niu ,  Zhen Chen ,  Haibo Guo

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/365

摘要： The present invention discloses a butylphthalide intravenous emulsion for intravenous injection or infusion, containing butylphthalide or derivatives thereof as an active ingredient in an amount of 0.01˜50 wt % and an excipient in an amount of 50˜99.99 wt %, based on the total weight of the emulsion.

公开(公告)号：US20070167516A1

公开(公告)日：2007-07-19

申请号：US11458650

申请日：2006-07-19

申请人： Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

发明人： Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

IPC分类号： A61K31/365

CPC分类号： A61K31/343

摘要： The inventive subject matter relates to the use of L-butylphthalide in the manufacturing of medicaments for the prevention and treatment of cerebral ischemia-induced disease. Cerebral ischemia of the animals or human induces cerebral infarction, neurological deficit, memory disorder, cerebral edema, cerebral apoplexy, metabolic disorder of energy, changes of cerebral blood flow, and the like. The in vivo experiments show that L-butylphthalide can effectively reduce the above-mentioned adverse symptoms induced by cerebral ischemia.

摘要翻译： 本发明涉及在制备用于预防和治疗脑缺血诱发疾病的药物中使用L-丁基苯酞。 动物或人的脑缺血诱导脑梗塞，神经功能缺损，记忆障碍，脑水肿，脑中风，能量代谢障碍，脑血流量变化等。 体内实验表明，L-丁基苯酞可有效减少上述脑缺血引起的不良反应。