公开(公告)号：US08728518B2

公开(公告)日：2014-05-20

申请号：US11574313

申请日：2005-08-26

Applicant: Zhentao Liu ,  Liying Yang ,  Hanyu Yang ,  Yuqing Gao ,  Dongmin Shen ,  Wenmin Guo ,  Xiaolong Feng ,  Jia Zheng

Inventor： Zhentao Liu ,  Liying Yang ,  Hanyu Yang ,  Yuqing Gao ,  Dongmin Shen ,  Wenmin Guo ,  Xiaolong Feng ,  Jia Zheng

IPC: A61K9/66

CPC classification number: A61K9/1075 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/2013 ,  A61K9/4858 ,  A61K31/34

Abstract: The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.

Abstract translation: 本发明涉及一种新型药物递送和释放系统，即丁基苯酞的自乳化药物递送系统（SEDDS），其制备方法及其在药物制剂中的用途。 药物递送系统根据所需的剂型，根据需要含有1％至65％的丁基苯酞和10％至65％的乳化剂，以及各种赋形剂。 本发明显着增加了丁基苯酞与胃肠道粘膜之间的接触面积，从而提高了药物的吸收性。

公开(公告)号：US20080319056A1

公开(公告)日：2008-12-25

申请号：US11574313

申请日：2005-08-26

Applicant: Zhentao Liu ,  Liying Yang ,  Hanyu Yang ,  Yuqing Gao ,  Dongmin Shen ,  Wenmin Guo ,  Xiaolong Feng ,  Jia Zheng

Inventor： Zhentao Liu ,  Liying Yang ,  Hanyu Yang ,  Yuqing Gao ,  Dongmin Shen ,  Wenmin Guo ,  Xiaolong Feng ,  Jia Zheng

IPC: A61K31/343 ,  A61P43/00

CPC classification number: A61K9/1075 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/2013 ,  A61K9/4858 ,  A61K31/34

Abstract: The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.

Abstract translation: 本发明涉及一种新型药物递送和释放系统，即丁基苯酞的自乳化药物递送系统（SEDDS），其制备方法及其在药物制剂中的用途。 药物递送系统根据所需的剂型，根据需要含有1％至65％的丁基苯酞和10％至65％的乳化剂，以及各种赋形剂。 本发明显着增加了丁基苯酞与胃肠道粘膜之间的接触面积，从而提高了药物的吸收性。

公开(公告)号：US20070167516A1

公开(公告)日：2007-07-19

申请号：US11458650

申请日：2006-07-19

Applicant: Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

Inventor： Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

IPC: A61K31/365

CPC classification number: A61K31/343

Abstract: The inventive subject matter relates to the use of L-butylphthalide in the manufacturing of medicaments for the prevention and treatment of cerebral ischemia-induced disease. Cerebral ischemia of the animals or human induces cerebral infarction, neurological deficit, memory disorder, cerebral edema, cerebral apoplexy, metabolic disorder of energy, changes of cerebral blood flow, and the like. The in vivo experiments show that L-butylphthalide can effectively reduce the above-mentioned adverse symptoms induced by cerebral ischemia.

Abstract translation: 本发明涉及在制备用于预防和治疗脑缺血诱发疾病的药物中使用L-丁基苯酞。 动物或人的脑缺血诱导脑梗塞，神经功能缺损，记忆障碍，脑水肿，脑中风，能量代谢障碍，脑血流量变化等。 体内实验表明，L-丁基苯酞可有效减少上述脑缺血引起的不良反应。

公开(公告)号：US08401698B2

公开(公告)日：2013-03-19

申请号：US10580239

申请日：2004-11-23

Applicant: Behnam Kamrani ,  Viktor Berbyuk ,  Xiaolong Feng ,  Daniel Wäppling

Inventor： Behnam Kamrani ,  Viktor Berbyuk ,  Xiaolong Feng ,  Daniel Wäppling

IPC: G06F19/00

CPC classification number: B25J9/1661 ,  G05B19/4188 ,  G05B2219/31076 ,  G05B2219/40336 ,  G05B2219/42217 ,  G05B2219/42224 ,  G05B2219/42337 ,  G05B2219/49071 ,  G05B2219/50118 ,  Y02P90/24 ,  Y02P90/26

Abstract: A method for optimizing performance of a robot. At least one experiment is designed including at least two tests. Each test differs from at least one other test in the experiment regarding the location of the task in relation to the robot. The boundaries that are allowable for location of a task are calculated/determined. The effect on optimality for at least one test in the experiment is calculated/determined. The experimental data is fit to an algorithm. The optimal location of the task is calculated/determined.

Abstract translation: 一种用于优化机器人性能的方法。 设计至少一个实验包括至少两个测试。 每个测试与实验中的至少一个其他测试不同，该测试关于任务相对于机器人的位置。 计算/确定任务位置允许的边界。 计算/确定了实验中至少一项测试对最优性的影响。 实验数据适合于算法。 计算/确定任务的最佳位置。

公开(公告)号：US20070106421A1

公开(公告)日：2007-05-10

申请号：US10580239

申请日：2004-11-23

Applicant: Behnam Kamrani ,  Viktor Berbyuk ,  Daniel Wappling ,  Xiaolong Feng

Inventor： Behnam Kamrani ,  Viktor Berbyuk ,  Daniel Wappling ,  Xiaolong Feng

IPC: G06F19/00

CPC classification number: B25J9/1661 ,  G05B19/4188 ,  G05B2219/31076 ,  G05B2219/40336 ,  G05B2219/42217 ,  G05B2219/42224 ,  G05B2219/42337 ,  G05B2219/49071 ,  G05B2219/50118 ,  Y02P90/24 ,  Y02P90/26

Abstract: A method for optimizing performance of a robot. At least one experiment is designed including at least two tests. Each test differs from at least one other test in the experiment regarding the location of the task in relation to the robot. The boundaries that are allowable for location of a task are calculated/determined. The effect on optimality for at least one test in the experiment is calculated/determined. The experimental data is fit to an algorithm. The optimal location of the task is calculated/determined.

Abstract translation: 一种用于优化机器人性能的方法。 设计至少一个实验包括至少两个测试。 每个测试与实验中的至少一个其他测试不同，该测试关于任务相对于机器人的位置。 计算/确定任务位置允许的边界。 计算/确定了实验中至少一项测试对最优性的影响。 实验数据适合于算法。 计算/确定任务的最佳位置。

公开(公告)号：US06742280B1

公开(公告)日：2004-06-01

申请号：US10129842

申请日：2002-09-13

Applicant: Anders Andrén ,  Stefan Backa ,  Johan Ekh ,  Xiaolong Feng ,  Thomas Liljenberg ,  Ulf Persson ,  Xiaojing Zhang

Inventor： Anders Andrén ,  Stefan Backa ,  Johan Ekh ,  Xiaolong Feng ,  Thomas Liljenberg ,  Ulf Persson ,  Xiaojing Zhang

IPC: F26B300

CPC classification number: D21F5/18 ,  D21F5/00 ,  D21F5/185

Abstract: A method in consolidation and drying of paper. A wet web is contacted with superheated steam, whose temperature is 200-600° C. for the purpose of reducing, by heat transfer from the superheated stream, the water content of the web by evaporation of a substantial part of the water in the same. The wet web is supported and transported by means of a heat-conductive, gas-impermeable belt whose width is equal to or exceeds the width of the web, and jets of the superheated steam are directed towards the side of the web facing away from the belt.

Abstract translation: 一种纸张整理和干燥的方法。 将湿纸幅与温度为200-600℃的过热蒸汽接触，以通过从过热流的热传递来减少幅材的水分含量，其中相当大部分水蒸发 。 湿纸幅通过宽度等于或超过纸幅宽度的导热不透气带来支撑和传送，而过热蒸汽的射流被引向纸幅背面远离 带。

公开(公告)号：US09795585B2

公开(公告)日：2017-10-24

申请号：US11458650

申请日：2006-07-19

Applicant: Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

Inventor： Zhentao Liu ,  Hongwu Zhang ,  Zhanqi Niu ,  Dongmin Shen ,  Rongduan Wang ,  Xiaolong Feng

IPC: A61K31/33 ,  A61K31/343

CPC classification number: A61K31/343

Abstract: The inventive subject matter relates to the use of L-butylphthalide in the manufacturing of medicaments for the prevention and treatment of cerebral ischemia-induced disease. Cerebral ischemia of the animals or human induces cerebral infarction, neurological deficit, memory disorder, cerebral edema, cerebral apoplexy, metabolic disorder of energy, changes of cerebral blood flow, and the like. The in vivo experiments show that L-butylphthalide can effectively reduce the above-mentioned adverse symptoms induced by cerebral ischemia.

公开(公告)号：US20110245334A1

公开(公告)日：2011-10-06

申请号：US13133894

申请日：2009-12-10

Applicant: Guanhua Du ,  Jinxu Wang ,  Song Wu ,  Ying Shi ,  Mei Gao ,  Yingui Li ,  Yan Qi ,  Dongmin Shen ,  Hongmei Guang ,  Haili Liu ,  Rui Liu ,  Xiaolong Feng

Inventor： Guanhua Du ,  Jinxu Wang ,  Song Wu ,  Ying Shi ,  Mei Gao ,  Yingui Li ,  Yan Qi ,  Dongmin Shen ,  Hongmei Guang ,  Haili Liu ,  Rui Liu ,  Xiaolong Feng

IPC: A61K31/353 ,  C07D311/60 ,  A61P9/12 ,  A61P9/00

CPC classification number: A61K31/352 ,  A61K9/0019 ,  A61K47/6951 ,  B82Y5/00

Abstract: Use of a racemate of pinocembrin, a racemate of pinocembrin salt, a racemate of pinocembrin precursor or a racemate of pinocembrin hydrate in manufacture of a medicament for prophylaxis and treatment of stroke. Particularly, use of pinocembrin racemate in manufacture of a medicament for treatment of acute ischemic stroke.

Abstract translation: 皮诺米布的外消旋物，皮诺卡因盐的外消旋物，皮诺卡因前体的外消旋物或丝素水合物的外消旋物在制备用于预防和治疗中风的药物中的用途。 特别地，在制备用于治疗急性缺血性卒中的药物中使用内啡珠外消旋体。