-
公开(公告)号：US07887816B2
公开(公告)日：2011-02-15
申请号：US11701214
申请日：2007-02-01
申请人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
发明人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
IPC分类号： A61K39/112 , C12N1/12
CPC分类号： C12R1/42 , A61K2035/11 , A61K2039/522 , C07K14/255 , Y02A50/484
摘要： The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
摘要翻译： 本发明涉及具有破坏位于Spi2致病岛内的基因表达的减毒突变和营养缺陷突变的沙门氏菌微生物。 因此，微生物具有双重突变，其有助于防止微生物的反应性，同时保持微生物的有效性以引发免疫应答。 本发明还涉及用于治疗和预防患者沙门氏菌感染的疫苗组合物和方法。
-
公开(公告)号：US06756042B1
公开(公告)日：2004-06-29
申请号：US09569601
申请日：2000-05-09
申请人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
发明人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
IPC分类号： A61K39112
CPC分类号： C12R1/42 , A61K2035/11 , A61K2039/522 , C07K14/255 , Y02A50/484
摘要： The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
-
公开(公告)号：US20080274139A1
公开(公告)日：2008-11-06
申请号：US11701214
申请日：2007-02-01
申请人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
发明人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
CPC分类号： C12R1/42 , A61K2035/11 , A61K2039/522 , C07K14/255 , Y02A50/484
摘要： The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
摘要翻译： 本发明涉及具有破坏位于Spi2致病岛内的基因表达的减毒突变和营养缺陷突变的沙门氏菌微生物。 因此，微生物具有双重突变，其有助于防止微生物的反应性，同时保持微生物的有效性以引发免疫应答。 本发明还涉及用于治疗和预防患者沙门氏菌感染的疫苗组合物和方法。
-
公开(公告)号：US07211264B2
公开(公告)日：2007-05-01
申请号：US10822053
申请日：2004-04-08
申请人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
发明人： Robert Graham Feldman , Gordon Dougan , Joseph David Santangelo , David William Holden , Jacqueline Elizabeth Shea , Zoe Hindle
IPC分类号： A01N63/00 , A61K39/112 , C12N1/12
CPC分类号： C12R1/42 , A61K2035/11 , A61K2039/522 , C07K14/255 , Y02A50/484
摘要： The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
摘要翻译： 本发明涉及具有破坏位于Spi2致病岛内的基因表达的减毒突变和营养缺陷突变的沙门氏菌微生物。 因此，微生物具有双重突变，其有助于防止微生物的反应性，同时保持微生物的有效性以引发免疫应答。 本发明还涉及用于治疗和预防患者沙门氏菌感染的疫苗组合物和方法。
-
-
-
搜索结果
4 条记录 (耗时 0.011 秒)
