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15 条记录 (耗时 0.035 秒)

    ATTENUATED GRAM NEGATIVE BACTERIA
    7.
    发明申请
    ATTENUATED GRAM NEGATIVE BACTERIA 有权
    衰减的灰色负面细菌

    公开(公告)号：US20090252766A1

    公开(公告)日：2009-10-08

    申请号：US12246809

    申请日：2008-10-07

    申请人： Helen Rachel CROOKE ,  Jacqueline Elizabeth Shea ,  Robert Graham Feldman ,  Sylvain Gabriel Goutebroze ,  Francois-Xavier Le Gros

    发明人： Helen Rachel CROOKE ,  Jacqueline Elizabeth Shea ,  Robert Graham Feldman ,  Sylvain Gabriel Goutebroze ,  Francois-Xavier Le Gros

    IPC分类号： A61K39/102 ,  C12N1/21

    CPC分类号： C07K14/285 ,  A61K39/00 ,  Y02A50/407

    摘要： Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.

    摘要翻译： 披露并要求保护的是革兰氏阴性细菌的突变体，其中所述细菌在核苷酸序列中具有至少一个突变，所述核苷酸序列编码具有等于或大于70％，75％，80％，85％ 90％，95％，96％，97％，98％或99％，其中氨基酸序列由选自SEQ ID NO：2,6,9,12,16的核苷酸序列的核苷酸序列编码 ，19，22，25，28，31，34，37，40，43，46，49，52，55，58，61，64，67，70，75，78，81，84，87，90，93 ; 所述突变导致细菌的毒力减弱。 还公开并要求保护含有这种突变体的免疫原性组合物和疫苗。

    Attenuated Gram Negative Bacteria
    10.
    发明申请
    Attenuated Gram Negative Bacteria 有权
    减毒革兰氏阴性细菌

    公开(公告)号：US20120009218A1

    公开(公告)日：2012-01-12

    申请号：US13091046

    申请日：2011-04-20

    申请人： Helen Rachel Crooke ,  Jacqueline Elizabeth Shea ,  Robert Graham Feldman ,  Sylvain Gabriel Goutebroze ,  Francois-Xavier Le Gros

    发明人： Helen Rachel Crooke ,  Jacqueline Elizabeth Shea ,  Robert Graham Feldman ,  Sylvain Gabriel Goutebroze ,  Francois-Xavier Le Gros

    IPC分类号： A61K39/02 ,  A61P31/04 ,  C12N1/21

    CPC分类号： C07K14/285 ,  A61K39/00 ,  Y02A50/407

    摘要： Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.

    摘要翻译： 披露并要求保护的是革兰氏阴性细菌的突变体，其中所述细菌在核苷酸序列中具有至少一个突变，所述核苷酸序列编码具有等于或大于70％，75％，80％，85％ 90％，95％，96％，97％，98％或99％，其中氨基酸序列由选自SEQ ID NO：2,6,9,12,16的核苷酸序列的核苷酸序列编码 ，19，22，25，28，31，34，37，40，43，46，49，52，55，58，61，64，67，70，75，78，81，84，87，90，93 ; 所述突变导致细菌的毒力减弱。 还公开并要求保护含有这种突变体的免疫原性组合物和疫苗。