公开(公告)号：US06884422B1

公开(公告)日：2005-04-26

申请号：US09807783

申请日：1999-10-10

Applicant: Jingye Liu ,  Pengfu Wang ,  Guangpu Li ,  Baosheng Xie ,  Zongming Song ,  Shuyan Li ,  Jing Liu ,  Ying Yu ,  Xizhen Guangpu Zhang ,  Ben Liang ,  Lingjiu Liu ,  Wei Wang ,  Ling Zhang ,  Yong Xue ,  Jing Li ,  Yuhong Li ,  Hui Lin ,  Zongju Wan

Inventor： Jingye Liu ,  Pengfu Wang ,  Guangpu Li ,  Baosheng Xie ,  Zongming Song ,  Shuyan Li ,  Jing Liu ,  Ying Yu ,  Xizhen Guangpu Zhang ,  Ben Liang ,  Lingjiu Liu ,  Wei Wang ,  Ling Zhang ,  Yong Xue ,  Jing Li ,  Yuhong Li ,  Hui Lin ,  Zongju Wan

IPC: A61K9/19 ,  A61K39/29 ,  A61P31/12 ,  A61K39/245 ,  C12N13/00 ,  C12N7/00

CPC classification number: A61K9/19 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/5254 ,  C12N2760/18434 ,  C12N2770/32434 ,  Y02A50/464

Abstract: The present invention relates to hepatitis A vaccine, especially to a lyophilized attenuated hepatitis A vaccine which can be stored at ambient temperature for extended periods of time, and to a method for producing the same. The present invention further relates to a stabilizer for lyophilized live vaccine and its use in improving thermostability of lyophilized live vaccine during lyophilization processing and storage period after lyophilization.

Abstract translation: 本发明涉及甲型肝炎疫苗，特别涉及可在环境温度下长时间储存​​的冻干减毒甲型肝炎疫苗及其制备方法。 本发明还涉及一种用于冻干活疫苗的稳定剂及其在冷冻干燥处理和冷冻干燥后的保存期间用于提高冻干活疫苗的热稳定性的用途。