公开(公告)号：US10245299B2

公开(公告)日：2019-04-02

申请号：US15124636

申请日：2015-03-10

申请人： 3-D MATRIX, LTD.

发明人： Manav Mehta ,  Hisashi Tsukada ,  Eun Seok Gil ,  Karl Gilbert ,  Satoru Kobayashi

IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61B17/34 ,  A61M16/04

摘要： Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.

公开(公告)号：US10654893B2

公开(公告)日：2020-05-19

申请号：US15121251

申请日：2015-03-10

申请人： 3-D MATRIX, LTD.

发明人： Eun Seok Gil ,  Karl Gilbert ,  Manav Mehta

IPC分类号： C07K7/08 ,  A61L27/22 ,  A61L24/10 ,  A61K38/00

摘要： The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc. that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).