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    COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL
    4.
    发明申请
    COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL 审中-公开
    FENTANYL的超快速输送组合物

    公开(公告)号：US20140170206A1

    公开(公告)日：2014-06-19

    申请号：US14188909

    申请日：2014-02-25

    Applicant: 3M Innovative Properties Company

    Inventor： Adam S. Cantor ,  Terrance W. Ocheltree ,  Cynthia A. Robles

    IPC: A61K9/00 ,  A61K31/4468

    CPC classification number: A61K9/7061 ,  A61K9/0014 ,  A61K9/7084 ,  A61K31/44 ,  A61K31/4468

    Abstract: A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.

    Abstract translation: 透皮药物递送组合物包含丙烯酸酯共聚物和约8％至约30％重量的芬太尼。 还提供了包含月桂酸甲酯或四甘醇作为渗透促进剂的透皮芬太尼递送组合物。 透皮药物递送组合物可用于制备用于递送芬太尼的透皮药物递送装置。

    COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL
    5.
    发明申请
    COMPOSITION FOR THE TRANSDERMAL DELIVERY OF FENTANYL 审中-公开
    FENTANYL的超快速输送组合物

    公开(公告)号：US20150313851A1

    公开(公告)日：2015-11-05

    申请号：US14799774

    申请日：2015-07-15

    Applicant: 3M Innovative Properties Company

    Inventor： Adam S. Cantor ,  Terrance W. Ocheltree ,  Cynthia A. Robles

    IPC: A61K9/70 ,  A61K31/4468

    CPC classification number: A61K9/7061 ,  A61K9/0014 ,  A61K9/7084 ,  A61K31/44 ,  A61K31/4468

    Abstract: A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.

    Abstract translation: 透皮药物递送组合物包含丙烯酸酯共聚物和约8％至约30％重量的芬太尼。 还提供了包含月桂酸甲酯或四甘醇作为渗透促进剂的透皮芬太尼递送组合物。 透皮药物递送组合物可用于制备用于递送芬太尼的透皮药物递送装置。

    TRANSDERMAL ADHESIVE PATCH ASSEMBLY WITH REMOVABLE MICRONEEDLE ARRAY AND METHOD OF USING SAME
    6.
    发明申请
    TRANSDERMAL ADHESIVE PATCH ASSEMBLY WITH REMOVABLE MICRONEEDLE ARRAY AND METHOD OF USING SAME 有权
    具有可拆卸麦克风阵列的透明胶粘带组件及其使用方法

    公开(公告)号：US20140243788A1

    公开(公告)日：2014-08-28

    申请号：US14352327

    申请日：2012-12-12

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： Adam S. Cantor ,  Andrew J. Stockholm

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61K9/703 ,  A61K9/7084 ,  A61M2037/0023 ,  A61M2037/0061

    Abstract: A transdermal adhesive patch assembly and method of using same. The assembly can include a backing, and an adhesive and a matrix coupled to the backing. The matrix can include an active ingredient. The assembly can further include a microneedle array in at least partially overlapping relationship with the matrix; and a carrier that couples the microneedle array to the matrix opposite the backing, wherein the carrier and the microneedle array form a skin treatment assembly that, along with the matrix, can be located on a flap. The method can include adhering at least a portion of the adhesive to skin to form an anchor; applying pressure adjacent the microneedle array to treat an area of the skin; moving the flap away from the skin; removing the skin treatment assembly to expose the matrix; and replacing the flap to position the matrix over the treated area of the skin.

    Abstract translation: 透皮贴剂组件及其使用方法。 该组件可以包括背衬，和粘合剂以及耦合到背衬的矩阵。 基质可以包括活性成分。 组件还可以包括与基质至少部分重叠的关系的微针阵列; 以及将微针阵列耦合到与背衬相对的矩阵的载体，其中载体和微针阵列形成皮肤治疗组件，其与基质一起可以位于瓣上。 该方法可以包括将粘合剂的至少一部分粘附到皮肤上以形成锚固件; 在微针阵列附近施加压力以治疗皮肤的一部分; 将皮瓣从皮肤上移开; 去除皮肤处理组件以暴露基质; 并更换皮瓣以将基质定位在皮肤的治疗区域上。

    INTEGRATED MICRONEEDLE ARRAY DELIVERY SYSTEM
    10.
    发明申请
    INTEGRATED MICRONEEDLE ARRAY DELIVERY SYSTEM 审中-公开
    集成式麦克风输送系统

    公开(公告)号：US20140236090A1

    公开(公告)日：2014-08-21

    申请号：US14350178

    申请日：2012-10-09

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： David J. Colburn ,  Erik J. Johnson ,  David H. Brandwein ,  Jerome E. Gysbers ,  Patrick J. Young ,  Adam S. Cantor

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

    Abstract: The present disclosure provides low-profile systems and methods for delivering a microneedle array. A delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate a stored energy device. The stored energy device can be designed to store a predetermined amount of potential energy that is greater or substantially greater than the energy necessary to release said energy. As the stored energy device is potentially capable of releasing substantially more energy than is required to cause the release, the amount of normal force applied to the skin can be minimized while sufficient application velocity is still generated.

    Abstract translation: 本公开提供了用于传送微针阵列的低调系统和方法。 递送系统包括可以固定到患者皮肤上并临时佩戴在患者皮肤上的壳体。 耦合到微针阵列的载体组件容纳在靠近存储的能量装置的壳体中。 存储的能量装置可被设计成存储大于或显着大于释放所述能量所需的能量的预定量的势能。 由于存储的能量装置潜在地能够释放比引起释放所需的能量更多的能量，所以施加到皮肤的法向力的量可以被最小化，同时仍然产生足够的施加速度。

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