公开(公告)号：US09878085B2

公开(公告)日：2018-01-30

申请号：US13794910

申请日：2013-03-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Horst-Dieter Lemke ,  Frank Wiese ,  Bodo von Harten ,  Martin Konig ,  Wolfgang Ramlow

IPC: A61M1/36

CPC classification number: A61M1/3633 ,  A61M2202/0439 ,  A61M2202/0057

Abstract: The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.

公开(公告)号：US20170266362A1

公开(公告)日：2017-09-21

申请号：US15505724

申请日：2015-08-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Bodo von Harten ,  Detlef Krieter ,  Horst-Dieter Lemke

IPC: A61M1/36

CPC classification number: A61M1/3633 ,  A61M1/34 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/3472 ,  A61M1/3679 ,  A61M1/3693 ,  A61M2202/0014 ,  A61M2202/0441 ,  A61M2202/0443 ,  A61M2202/0445 ,  B01D15/26 ,  B01D39/14 ,  B01D61/00 ,  B01D63/02 ,  B01D69/02 ,  B01D2325/20 ,  B01J20/28

Abstract: A blood treatment system comprising at least one first device and at least one second device, wherein the first device is a membrane filter for the removal of toxic mediators from blood and the second device is suitable for the removal of granulocytes and monocytes from blood. The first device has a first blood flow path a first blood flow path for conducting blood through and the second device has a second blood flow path. The first and second devices are serially connected in succession in such a way that the first blood flow path is in fluid communication with the second blood flow path.The membrane has an interior filter space in its housing and a semipermeable membrane arranged in the interior filter space, which membrane divides the interior filter space into a retentate chamber and permeate chamber. The housing has a blood inlet device and a blood outlet device that are in fluid communication with the retentate chamber, as well as a permeate outlet for diverting permeate from the permeate chamber. The blood inlet device, the retentate chamber and the blood outlet device form the first blood flow path. The membrane filter has a separation characteristic such that the sieve coefficient for albumin, SKAlb, is within the range from 0.015 to 0.35.