公开(公告)号：US20220334108A1

公开(公告)日：2022-10-20

申请号：US17762945

申请日：2020-09-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Frederica Sgolastra ,  Stephen B. Roscoe ,  Daniel M. Dohmeier ,  Masayuki Nakamura ,  Catherine A. Bothof ,  Deniz Yuksel Yurt ,  David D. Johnson ,  Kyle A. Kalstabakken ,  Minghua Dai ,  Myungchan Kang ,  Neil Percy ,  Leslie M. Horton ,  Stephen M. Kennedy

IPC: G01N33/53 ,  G01N33/543 ,  G01N33/552 ,  G01N33/74 ,  C03C11/00 ,  C03C17/30

Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.