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公开(公告)号：US09365567B2
公开(公告)日：2016-06-14
申请号：US14502157
申请日：2014-09-30
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah J. Slania
IPC: C07D471/04 , A61K31/4745 , C07D413/14
CPC classification number: C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。
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公开(公告)号：US20150023990A1
公开(公告)日：2015-01-22
申请号：US14502157
申请日：2014-09-30
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah J. Slania
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。
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公开(公告)号：US20160280707A1
公开(公告)日：2016-09-29
申请号：US15181068
申请日：2016-06-13
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah J. Slania
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
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![N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS](/abs-image/US/2022/06/09/US20220177471A1/abs.jpg.150x150.jpg)
4.发明申请公开(公告)号：US20220177471A1
公开(公告)日：2022-06-09
申请号：US17594415
申请日：2020-05-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： George W. Griesgraber , Michael J. Rice , Hannah C. Cohen , Devon M. Hunerdosse , Adam D. Miller , Joshua R. Wurst
IPC: C07D471/04
Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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公开(公告)号：US10557069B2
公开(公告)日：2020-02-11
申请号：US16291098
申请日：2019-03-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Michael J. Bulinski , Michael G. Costello , John G. Owens , Michael J. Rice
Abstract: A working fluid that includes a fluorinated olefin compound represented by the following general formula (I):
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Patent Agency Ranking
公开(公告)号：US09856254B2
公开(公告)日：2018-01-02
申请号：US15181068
申请日：2016-06-13
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah J. Slania
IPC: C07D413/14 , C07D519/00 , A61K31/4745 , C07D471/04
CPC classification number: C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
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公开(公告)号：US20190225852A1
公开(公告)日：2019-07-25
申请号：US16291098
申请日：2019-03-04
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Michael J. Bulinski , Michael G. Costello , John G. Owens , Michael J. Rice
Abstract: A working fluid that includes a fluorinated olefin compound represented by the following general formula (I):
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公开(公告)号：US10280351B2
公开(公告)日：2019-05-07
申请号：US15926242
申请日：2018-03-20
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Michael J. Bulinski , Michael G. Costello , John G. Owens , Michael J. Rice
Abstract: A working fluid that includes a fluorinated olefin compound represented by the following general formula (I):
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公开(公告)号：US20180320040A1
公开(公告)日：2018-11-08
申请号：US15926242
申请日：2018-03-20
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Michael J. Bulinski , Michael G. Costello , John G. Owens , Michael J. Rice
CPC classification number: C09K5/045 , A62D1/0057 , A62D1/0092 , C08J9/0028 , C08J9/141 , C08J2375/04 , C09K2205/22 , F01K25/08 , F28D15/00
Abstract: A working fluid that includes a fluorinated olefin compound represented by the following general formula (I):
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公开(公告)号：US09546184B2
公开(公告)日：2017-01-17
申请号：US14732815
申请日：2015-06-08
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Ryan B. Prince , Bryon A. Merrill , Philip D. Heppner , Tushar A. Kshirsagar , Joshua R. Wurst , Karl J. Manske , Michael J. Rice
IPC: C07D513/04 , C07D519/00
CPC classification number: C07D513/04 , C07D519/00
Abstract: Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Abstract translation: 含有这些化合物的化合物，中间体，制备方法和这些化合物作为免疫调节剂的使用方法的6,7,8或9位具有烷氧基取代基的噻唑并喹啉和噻唑并萘并用于诱导动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。
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