公开(公告)号：US09856254B2

公开(公告)日：2018-01-02

申请号：US15181068

申请日：2016-06-13

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kyle J. Lindstrom ,  Bryon A. Merrill ,  Chad A. Haraldson ,  Michael J. Rice ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Joshua R. Wurst ,  Shri Niwas ,  Sarah J. Slania

IPC: C07D413/14 ,  C07D519/00 ,  A61K31/4745 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

公开(公告)号：US09365567B2

公开(公告)日：2016-06-14

申请号：US14502157

申请日：2014-09-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kyle J. Lindstrom ,  Bryon A. Merrill ,  Chad A. Haraldson ,  Michael J. Rice ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Joshua R. Wurst ,  Shri Niwas ,  Sarah J. Slania

IPC: C07D471/04 ,  A61K31/4745 ,  C07D413/14

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。

公开(公告)号：US20150023990A1

公开(公告)日：2015-01-22

申请号：US14502157

申请日：2014-09-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kyle J. Lindstrom ,  Bryon A. Merrill ,  Chad A. Haraldson ,  Michael J. Rice ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Joshua R. Wurst ,  Shri Niwas ,  Sarah J. Slania

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。

公开(公告)号：US20160280707A1

公开(公告)日：2016-09-29

申请号：US15181068

申请日：2016-06-13

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kyle J. Lindstrom ,  Bryon A. Merrill ,  Chad A. Haraldson ,  Michael J. Rice ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Joshua R. Wurst ,  Shri Niwas ,  Sarah J. Slania

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.